Marja T. Nevalainen, MD, PhD

Professor, Eminent Scholar, Department of Pathology and Pharmacology & Toxicology; Assistant Dean of Research, Medical College of Wisconsin; Associate Director (Education), Medical College of Wisconsin Cancer Center; Director, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center

Contact Information

Education

University of Turku, School of Medicine, Turku, Finland, MD
University of Turku, Turku, Finland, Cell Biology, PhD

Biography

Marja Nevalainen, MD, PhD is an internationally recognized leader in the field of cytokine and steroid hormone signaling in prostate cancer. The focus of her laboratory is on translational prostate cancer research to develop and improve diagnostics and therapy for prostate cancer. Dr. Nevalainen holds the title of Eminent Scholar at MCW. She is also Director of Prostate Cancer Center of Excellence at MCW Cancer Center, which is a multi-disciplinary hub for prostate cancer research within the institution with an international collaborative network. Dr. Nevalainen serves as Assistant Dean for Research at MCW, and Associate Director of Education for the MCW Cancer Center. Her primary appointment is in the Department of Pathology, and a secondary appointment in the Department of Pharmacology and Toxicology. Dr. Nevalainen has extensive experience in collaborative research, mentoring and leadership from her previous roles at Sidney Kimmel Cancer Center at Thomas Jefferson University as Associate Director of Education and Vice Chair of Education in the Department of Cancer Biology.

Honors and Awards

General Medicine Board Certification

Research Interests

Jak-Stat signaling
Prostate cancer progression
Therapy development
Companion diagnostics
Predictive Factors
DNA repair
Radiation therapy
In vitro and in vivo models
3D tumor explant culture
Epithelial-mesenchymal transition
Cancer stem-like cell properties
Metastases models
Small molecule therapeutics

Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.

(Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT.) Cancers (Basel). 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020
Cytokines, JAK-STAT Signaling and Radiation-Induced DNA Repair in Solid Tumors: Novel Opportunities for Radiation Therapy.

(Hall WA, Sabharwal L, Udhane V, Maranto C, Nevalainen MT.) Int J Biochem Cell Biol. 2020 Oct;127:105827 PMID: 32822847 SCOPUS ID: 2-s2.0-85090734995 08/22/2020
Accurate segmentation of prostate cancer histomorphometric features using a weakly supervised convolutional neural network.

(Bukowy JD, Foss H, McGarry SD, Lowman AK, Hurrell SL, Iczkowski KA, Banerjee A, Bobholz SA, Barrington A, Dayton A, Unteriner J, Jacobsohn K, See WA, Nevalainen MT, Nencka AS, Ethridge T, Jarrard DF, LaViolette PS.) J Med Imaging (Bellingham). 2020 Sep;7(5):057501 PMID: 33062803 PMCID: PMC7550797 10/17/2020
Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors.

(Udhane V, Maranto C, Hoang DT, Gu L, Erickson A, Devi S, Talati PG, Banerjee A, Iczkowski KA, Jacobsohn K, See WA, Mirtti T, Kilari D, Nevalainen MT.) Mol Cancer Ther. 2020 01;19(1):231-246 PMID: 31548294 PMCID: PMC6946850 SCOPUS ID: 2-s2.0-85077669370 09/25/2019
Positive STAT5 Protein and Locus Amplification Status Predicts Recurrence after Radical Prostatectomy to Assist Clinical Precision Management of Prostate Cancer.

(Haddad BR, Erickson A, Udhane V, LaViolette PS, Rone JD, Kallajoki MA, See WA, Rannikko A, Mirtti T, Nevalainen MT.) Cancer Epidemiol Biomarkers Prev. 2019 10;28(10):1642-1651 PMID: 31292140 PMCID: PMC6774884 SCOPUS ID: 2-s2.0-85072849403 07/12/2019
Gleason Probability Maps: A Radiomics Tool for Mapping Prostate Cancer Likelihood in MRI Space.

(McGarry SD, Bukowy JD, Iczkowski KA, Unteriner JG, Duvnjak P, Lowman AK, Jacobsohn K, Hohenwalter M, Griffin MO, Barrington AW, Foss HE, Keuter T, Hurrell SL, See WA, Nevalainen MT, Banerjee A, LaViolette PS.) Tomography. 2019 03;5(1):127-134 PMID: 30854450 PMCID: PMC6403022 SCOPUS ID: 2-s2.0-85071529534 03/12/2019
Targeting the STAT5 pathway in Ph+ acute lymphoblastic leukemia.

(Minieri V, De Dominici M, Nevalainen MT, Calabretta B.) Oncotarget. 2018 Dec 04;9(95):36726-36727 PMID: 30613358 PMCID: PMC6298402 01/08/2019
Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia.

(Minieri V, De Dominici M, Porazzi P, Mariani SA, Spinelli O, Rambaldi A, Peterson LF, Porcu P, Nevalainen MT, Calabretta B.) Cancer Res. 2018 10 15;78(20):5793-5807 PMID: 30154155 PMCID: PMC7100125 SCOPUS ID: 2-s2.0-85054889112 08/30/2018
Radio-pathomic Maps of Epithelium and Lumen Density Predict the Location of High-Grade Prostate Cancer.

(McGarry SD, Hurrell SL, Iczkowski KA, Hall W, Kaczmarowski AL, Banerjee A, Keuter T, Jacobsohn K, Bukowy JD, Nevalainen MT, Hohenwalter MD, See WA, LaViolette PS.) Int J Radiat Oncol Biol Phys. 2018 08 01;101(5):1179-1187 PMID: 29908785 PMCID: PMC6190585 SCOPUS ID: 2-s2.0-85048748761 06/18/2018
STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair.

(Maranto C, Udhane V, Hoang DT, Gu L, Alexeev V, Malas K, Cardenas K, Brody JR, Rodeck U, Bergom C, Iczkowski KA, Jacobsohn K, See W, Schmitt SM, Nevalainen MT.) Clin Cancer Res. 2018 04 15;24(8):1917-1931 PMID: 29483142 PMCID: PMC6036914 SCOPUS ID: 2-s2.0-85044579498 02/28/2018
Optimized b-value selection for the discrimination of prostate cancer grades, including the cribriform pattern, using diffusion weighted imaging.

(Hurrell SL, McGarry SD, Kaczmarowski A, Iczkowski KA, Jacobsohn K, Hohenwalter MD, Hall WA, See WA, Banerjee A, Charles DK, Nevalainen MT, Mackinnon AC, LaViolette PS.) J Med Imaging (Bellingham). 2018 01;5(1):011004 PMID: 29098169 PMCID: PMC5658575 11/04/2017
Erratum: ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development.

(Sreenath TL, Macalindong SS, Mikhalkevich N, Sharad S, Mohamed A, Young D, Borbiev T, Xavier C, Gupta R, Jamal M, Babcock K, Tan SH, Nevalainen MT, Dobi A, Petrovics G, Sesterhenn IA, Rosner IL, Bieberich CJ, Nelson P, Vasioukhin V, Srivastava S.) Sci Rep. 2017 09 06;7(1):10693 PMID: 28878398 PMCID: PMC5587674 SCOPUS ID: 2-s2.0-85063930212 09/08/2017

Marja T. Nevalainen, MD, PhD