Matt Scaglione, PhD

Assistant Professor

Locations

Biochemistry
TBRC C1875

Contact Information

Biography

K. Matthew Scaglione received his Bachelor of Science degree in Biology from McKendree University in 2001 and his Doctorate in Biochemistry from Saint Louis University School of Medicine in 2007 where his research focused on ubiquitin pathways in cancer. He performed postdoctoral studies at the University of Michigan School of Medicine from 2007 until 2013 investigating the role of protein quality control pathways in neurodegenerative diseases. During his postdoctoral studies Dr. Scaglione was awarded a F32 (Ruth L. Kirschstein National Research Service Award) and a NIH K99/R00 (Pathway to Independence Award). Dr. Scaglione joined the faculty of the Medical College of Wisconsin in 2013.

View more information about the Scaglione Lab

Honors and Awards

Ruth L. Kirschstein National Research Service Award Winner
Pathway to Independence Award winner

Education

PhD, Saint Louis University School of Medicine, 2007
BS, McKendree University, 2001

Research Interests

The Scaglione lab investigates protein aggregation in neurodegenerative diseases. The lab has two main areas of focus, the first focuses on developing strategies to enhance neuroprotective protein quality control pathways. The second focuses on understanding how the social amoeba, Dictyostelium discoideum, naturally resists protein aggregation. Our ultimate goal is to develop therapeutics that can be used to treat neurodegenerative diseases.

SRCP1 Conveys Resistance to Polyglutamine Aggregation.

(Santarriaga S, Haver HN, Kanack AJ, Fikejs AS, Sison SL, Egner JM, Bostrom JR, Seminary ER, Hill RB, Link BA, Ebert AD, Scaglione KM.) Mol Cell. 2018 Jul 19;71(2):216-228.e7.
Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP.

(Kanack AJ, Newsom OJ, Scaglione KM.) J Biol Chem. 2018 02 23;293(8):2735-2743.
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.

(Wang B, Zeng L, Merillat SA, Fischer S, Ochaba J, Thompson LM, Barmada SJ, Scaglione KM, Paulson HL.) Neurobiol Dis. 2018 Jan;109(Pt A):127-136.
Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.

(Sutton JR, Blount JR, Libohova K, Tsou WL, Joshi GS, Paulson HL, Costa MDC, Scaglione KM, Todi SV.) Hum Mol Genet. 2017 04 15;26(8):1419-1431.
Erratum to: The loop-less Cdc34 E2 mutant defective polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2.

(Lass A, Cocklin R, Scaglione KM, Skowyra M, Korolev S, Goebl M, Skowyra D.) Cell Div. 2016;11:13.
USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila.

(Ristic G, Tsou WL, Guzi E, Kanack AJ, Scaglione KM, Todi SV.) J Biol Chem. 2016 Apr 22;291(17):9161-72.
Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.

(Wang B, Merillat SA, Vincent M, Huber AK, Basrur V, Mangelberger D, Zeng L, Elenitoba-Johnson K, Miller RA, Irani DN, Dlugosz AA, Schnell S, Scaglione KM, Paulson HL.) J Biol Chem. 2016 Feb 05;291(6):3030-42.
The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation.

(Santarriaga S, Petersen A, Ndukwe K, Brandt A, Gerges N, Bruns Scaglione J, Scaglione KM.) J Biol Chem. 2015 Oct 16;290(42):25571-8.
Allosteric regulation of deubiquitylase activity through ubiquitination.

(Faggiano S, Menon RP, Kelly GP, Todi SV, Scaglione KM, Konarev PV, Svergun DI, Paulson HL, Pastore A.) Front Mol Biosci. 2015;2:2.
A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins.

(Zhang H, Amick J, Chakravarti R, Santarriaga S, Schlanger S, McGlone C, Dare M, Nix JC, Scaglione KM, Stuehr DJ, Misra S, Page RC.) Structure. 2015 Mar 03;23(3):472-482.
Intrinsic disorder drives N-terminal ubiquitination by Ube2w.

(Vittal V, Shi L, Wenzel DM, Scaglione KM, Duncan ED, Basrur V, Elenitoba-Johnson KS, Baker D, Paulson HL, Brzovic PS, Klevit RE.) Nat Chem Biol. 2015 Jan;11(1):83-9.
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.

(Blount JR, Tsou WL, Ristic G, Burr AA, Ouyang M, Galante H, Scaglione KM, Todi SV.) Nat Commun. 2014 Aug 21;5:4638.

Matt Scaglione, PhD