Meetha M. Medhora, PhD

Professor, Radiation Oncology, Pulmonary Medicine and Physiology

Locations

Radiation Oncology

Contact Information

mmedhora@mcw.edu

Education

PhD, Molecular Biology, Jawaharial Nehru University, New Delhi, India, 1984
MS, Life Sciences, Jawaharlal Nehru University, New Delhi, India, 1979
BS, Human Physiology, Physics and Chemistry, First Class Presidency College, University of Calcutta, India, 1977

Biography

Training

Research Associate, Renal Division, Jewish Hospital at Washington University Medical Center, St. Louis, MO (1990-1994)

Postdoctoral Fellow, Department of Genetics, Washington School of Medicine, St. Louis, MO (1984-1990)

Research Interests

Mitigation of radiation injury to the lungs
Vasoreactive and antiapoptotic actions of epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE, products of the essential fatty acid, arachidonic acid

Prophylactic supplementation of 20-HETE ameliorates hypoxia/reoxygenation injury in pulmonary vascular endothelial cells by inhibiting apoptosis.

(Sugumaran P, Narayanan V, Zhu D, Medhora M, Jacobs ER, Chandramohan Y, Selvaraj V, Dhanasekaran A.) Acta Histochem. 2019 Nov 06:151461.
Optical Metabolic Imaging for Assessment of Radiation-Induced Injury to Rat Kidney and Mitigation by Lisinopril.

(Mehrvar S, la Cour MF, Medhora M, Camara AKS, Ranji M.) Ann Biomed Eng. 2019 Jul;47(7):1564-1574.
Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3.

(Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora M, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C.) Am J Physiol Heart Circ Physiol. 2019 Jun 01;316(6):H1267-H1280.
Cardiac Remodeling and Reversible Pulmonary Hypertension During Pneumonitis in Rats after 13-Gy Partial-Body Irradiation with Minimal Bone Marrow Sparing: Effect of Lisinopril.

(Jacobs ER, Narayanan J, Fish BL, Gao F, Harmann LM, Bergom C, Gasperetti T, Strande JL, Medhora M.) Health Phys. 2019 Apr;116(4):558-565.
Delayed Effects of Acute Radiation Exposure (Deare) in Juvenile and Old Rats: Mitigation by Lisinopril.

(Medhora M, Gao F, Gasperetti T, Narayanan J, Khan AH, Jacobs ER, Fish BL.) Health Phys. 2019 Apr;116(4):529-545.
Effects of Diet on Late Radiation Injuries in Rats.

(Moulder JE, Fish BL, Cohen EP, Flowers JB, Medhora M.) Health Phys. 2019 Apr;116(4):566-570.
WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to non-human primates (NHP).

(Fish BL, MacVittie TJ, Szabo A, Moulder JE, Medhora M.) Int J Radiat Biol. 2018 Dec 21:1-42.
Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins.

(Ma C, Beyer AM, Durand M, Clough AV, Zhu D, Norwood Toro L, Terashvili M, Ebben JD, Hill RB, Audi SH, Medhora M, Jacobs ER.) Arterioscler Thromb Vasc Biol. 2018 03;38(3):622-635.
Optical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury.

(la Cour MF, Mehrvar S, Heisner JS, Motlagh MM, Medhora M, Ranji M, Camara AKS.) J Biomed Opt. 2018 01;23(1):1-9.
Optical cryoimaging for assessment of radiation-induced injury to rat kidney metabolic state

(Mehrvar S, Funding La Cour M, Medhora M, Camara AKS, Ranji M.) Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2018;10497.
Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging.

(Audi SH, Jacobs ER, Zhang X, Camara AKS, Zhao M, Medhora MM, Rizzo B, Clough AV.) Shock. 2017 10;48(4):467-476.
Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats.

(Gao F, Liu P, Narayanan J, Yang M, Fish BL, Liu Y, Liang M, Jacobs ER, Medhora M.) Sci Rep. 2017 03 17;7:44132.

Meetha M. Medhora, PhD