Meetha M. Medhora, PhD

Professor, Radiation Oncology, Pulmonary Medicine and Physiology

Locations

Radiation Oncology

Contact Information

mmedhora@mcw.edu

Education

PhD, Molecular Biology, Jawaharial Nehru University, New Delhi, India, 1984
MS, Life Sciences, Jawaharlal Nehru University, New Delhi, India, 1979
BS, Human Physiology, Physics and Chemistry, First Class Presidency College, University of Calcutta, India, 1977

Biography

Training

Research Associate, Renal Division, Jewish Hospital at Washington University Medical Center, St. Louis, MO (1990-1994)

Postdoctoral Fellow, Department of Genetics, Washington School of Medicine, St. Louis, MO (1984-1990)

Research Interests

Mitigation of radiation injury to the lungs
Vasoreactive and antiapoptotic actions of epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE, products of the essential fatty acid, arachidonic acid

Prophylactic supplementation of 20-HETE ameliorates hypoxia/reoxygenation injury in pulmonary vascular endothelial cells by inhibiting apoptosis.

(Sugumaran P, Narayanan V, Zhu D, Medhora M, Jacobs ER, Chandramohan Y, Selvaraj V, Dhanasekaran A.) Acta Histochem. 2020 Jan;122(1):151461 PMID: 31706620 SCOPUS ID: 2-s2.0-85075466040 11/11/2019
WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to nonhuman primates (NHP).

(Fish BL, MacVittie TJ, Szabo A, Moulder JE, Medhora M.) Int J Radiat Biol. 2020 Jan;96(1):81-92 PMID: 30575429 SCOPUS ID: 2-s2.0-85060053811 12/24/2018
Optical Metabolic Imaging for Assessment of Radiation-Induced Injury to Rat Kidney and Mitigation by Lisinopril.

(Mehrvar S, la Cour MF, Medhora M, Camara AKS, Ranji M.) Ann Biomed Eng. 2019 Jul;47(7):1564-1574 PMID: 30963380 SCOPUS ID: 2-s2.0-85064248795 04/10/2019
Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3.

(Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora M, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C.) Am J Physiol Heart Circ Physiol. 2019 Jun 01;316(6):H1267-H1280 PMID: 30848680 PMCID: PMC6620678 SCOPUS ID: 2-s2.0-85066837925 03/09/2019
Cardiac Remodeling and Reversible Pulmonary Hypertension During Pneumonitis in Rats after 13-Gy Partial-Body Irradiation with Minimal Bone Marrow Sparing: Effect of Lisinopril.

(Jacobs ER, Narayanan J, Fish BL, Gao F, Harmann LM, Bergom C, Gasperetti T, Strande JL, Medhora M.) Health Phys. 2019 Apr;116(4):558-565 PMID: 30624347 PMCID: PMC6384144 SCOPUS ID: 2-s2.0-85061215751 01/10/2019
Delayed Effects of Acute Radiation Exposure (Deare) in Juvenile and Old Rats: Mitigation by Lisinopril.

(Medhora M, Gao F, Gasperetti T, Narayanan J, Khan AH, Jacobs ER, Fish BL.) Health Phys. 2019 Apr;116(4):529-545 PMID: 30624354 PMCID: PMC6384142 SCOPUS ID: 2-s2.0-85061959951 01/10/2019
Effects of Diet on Late Radiation Injuries in Rats.

(Moulder JE, Fish BL, Cohen EP, Flowers JB, Medhora M.) Health Phys. 2019 Apr;116(4):566-570 PMID: 30624356 PMCID: PMC6384138 SCOPUS ID: 2-s2.0-85061974646 01/10/2019
Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins.

(Ma C, Beyer AM, Durand M, Clough AV, Zhu D, Norwood Toro L, Terashvili M, Ebben JD, Hill RB, Audi SH, Medhora M, Jacobs ER.) Arterioscler Thromb Vasc Biol. 2018 03;38(3):622-635 PMID: 29419407 PMCID: PMC5823793 SCOPUS ID: 2-s2.0-85047900228 02/09/2018
Optical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury.

(la Cour MF, Mehrvar S, Heisner JS, Motlagh MM, Medhora M, Ranji M, Camara AKS.) J Biomed Opt. 2018 01;23(1):1-9 PMID: 29352564 PMCID: PMC5774173 SCOPUS ID: 2-s2.0-85040834320 01/21/2018
Optical cryoimaging for assessment of radiation-induced injury to rat kidney metabolic state

(Mehrvar S, Funding La Cour M, Medhora M, Camara AKS, Ranji M.) Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2018;10497 SCOPUS ID: 2-s2.0-85046372213 01/01/2018
Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging.

(Audi SH, Jacobs ER, Zhang X, Camara AKS, Zhao M, Medhora MM, Rizzo B, Clough AV.) Shock. 2017 10;48(4):467-476 PMID: 28915216 PMCID: PMC5636640 SCOPUS ID: 2-s2.0-85017424389 09/16/2017
Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats.

(Gao F, Liu P, Narayanan J, Yang M, Fish BL, Liu Y, Liang M, Jacobs ER, Medhora M.) Sci Rep. 2017 03 17;7:44132 PMID: 28303893 PMCID: PMC5355888 SCOPUS ID: 2-s2.0-85015404996 03/18/2017

Meetha M. Medhora, PhD