Oleg Palygin, PhD
Assistant Professor
Locations
- Physiology
Contact Information
Education
MS, Taras Shevchenko National University, 1999
Postdoctoral Scholar, Molecular Physiology and Biophysics, University of Iowa
Postdoctoral Fellow, School of Life Sciences, Warwick University
Research Interests
The capacity of the human kidney to control and regulate cardiovascular health is enormous and has been implicated in many of the physiological factors associated with the general health status. Today, a greater understanding has been achieved of the cellular and molecular mechanisms underlying the processes of renal function, and how these processes may become disordered in chronic kidney disease states such as hypertension, polycystic kidney and diabetes mellitus.
Our laboratory is interested in several aspects of the kidney: its ability to control and regulate body electrolytes, its vulnerability to genetically related mutations, oxidative stress, albuminuria and the role that transport potassium channels, protease activated receptors and the purines like ATP play in these processes.
Publications
-
Relationship between the renin-angiotensin-aldosterone system and renal Kir5.1 channels.
(Manis AD, Palygin O, Khedr S, Levchenko V, Hodges MR, Staruschenko A.) Clin Sci (Lond). 2019 Dec 20;133(24):2449-2461 PMID: 31799617 SCOPUS ID: 2-s2.0-85076876405 12/05/2019
-
Metabolic rewiring of the hypertensive kidney.
(Rinschen MM, Palygin O, Guijas C, Palermo A, Palacio-Escat N, Domingo-Almenara X, Montenegro-Burke R, Saez-Rodriguez J, Staruschenko A, Siuzdak G.) Sci Signal. 2019 Dec 10;12(611) PMID: 31822592 SCOPUS ID: 2-s2.0-85076355497 12/12/2019
-
Progression of diabetic kidney disease in T2DN rats.
(Palygin O, Spires D, Levchenko V, Bohovyk R, Fedoriuk M, Klemens CA, Sykes O, Bukowy JD, Cowley AW Jr, Lazar J, Ilatovskaya DV, Staruschenko A.) Am J Physiol Renal Physiol. 2019 Dec 01;317(6):F1450-F1461 PMID: 31566426 PMCID: PMC6960784 SCOPUS ID: 2-s2.0-85075960951 10/01/2019
-
Vibrodissociation method for isolation of defined nephron segments from human and rodent kidneys.
(Isaeva E, Fedoriuk M, Bohovyk R, Klemens CA, Khedr S, Golosova D, Levchenko V, El-Meanawy A, Palygin O, Staruschenko A.) Am J Physiol Renal Physiol. 2019 Nov 01;317(5):F1398-F1403 PMID: 31588797 PMCID: PMC6879945 SCOPUS ID: 2-s2.0-85074674820 10/08/2019
-
(LaDisa JF Jr, Tomita-Mitchell A, Stamm K, Bazan K, Mahnke DK, Goetsch MA, Wegter BJ, Gerringer JW, Repp K, Palygin O, Zietara AP, Krolikowski MM, Eddinger TJ, Alli AA, Mitchell ME.) Physiol Genomics. 2019 06 01;51(6):177-185 PMID: 31002586 PMCID: PMC6620646 SCOPUS ID: 2-s2.0-85066457176 04/20/2019
-
Role of TRPC6 in Progression of Diabetic Kidney Disease.
(Staruschenko A, Spires D, Palygin O.) Curr Hypertens Rep. 2019 May 21;21(7):48 PMID: 31115705 PMCID: PMC6814005 SCOPUS ID: 2-s2.0-85066146041 05/23/2019
-
Increased ENaC activity during kidney preservation in Wisconsin solution.
(Khedr S, Palygin O, Pavlov TS, Blass G, Levchenko V, Alsheikh A, Brands MW, El-Meanawy A, Staruschenko A.) BMC Nephrol. 2019 04 29;20(1):145 PMID: 31035971 PMCID: PMC6489205 SCOPUS ID: 2-s2.0-85065255744 05/01/2019
-
(Puissant MM, Muere C, Levchenko V, Manis AD, Martino P, Forster HV, Palygin O, Staruschenko A, Hodges MR.) FASEB J. 2019 04;33(4):5067-5075 PMID: 30605394 PMCID: PMC6436665 SCOPUS ID: 2-s2.0-85064111657 01/04/2019
-
Postprandial Effects on ENaC-Mediated Sodium Absorption.
(Blass G, Klemens CA, Brands MW, Palygin O, Staruschenko A.) Sci Rep. 2019 Mar 12;9(1):4296 PMID: 30862903 PMCID: PMC6414683 SCOPUS ID: 2-s2.0-85062847686 03/14/2019
-
Fluorescent Imaging and Microscopy for Dynamic Processes in Rats.
(Sandoval RM, Molitoris BA, Palygin O.) Methods Mol Biol. 2019;2018:151-175 PMID: 31228156 PMCID: PMC6693343 SCOPUS ID: 2-s2.0-85068189810 06/23/2019
-
Characterization of purinergic receptor expression in ARPKD cystic epithelia.
(Palygin O, Ilatovskaya DV, Levchenko V, Klemens CA, Dissanayake L, Williams AM, Pavlov TS, Staruschenko A.) Purinergic Signal. 2018 12;14(4):485-497 PMID: 30417216 PMCID: PMC6298916 SCOPUS ID: 2-s2.0-85056334780 11/13/2018
-
(Manis AD, Hodges MR, Staruschenko A, Palygin O.) Am J Physiol Renal Physiol. 2019 Dec 16 PMID: 31841387 12/17/2019