Oleg Palygin, PhD
Assistant Professor
Locations
- Physiology
Contact Information
Education
MS, Taras Shevchenko National University, 1999
Postdoctoral Scholar, Molecular Physiology and Biophysics, University of Iowa
Postdoctoral Fellow, School of Life Sciences, Warwick University
Research Interests
The capacity of the human kidney to control and regulate cardiovascular health is enormous and has been implicated in many of the physiological factors associated with the general health status. Today, a greater understanding has been achieved of the cellular and molecular mechanisms underlying the processes of renal function, and how these processes may become disordered in chronic kidney disease states such as hypertension, polycystic kidney and diabetes mellitus.
Our laboratory is interested in several aspects of the kidney: its ability to control and regulate body electrolytes, its vulnerability to genetically related mutations, oxidative stress, albuminuria and the role that transport potassium channels, protease activated receptors and the purines like ATP play in these processes.
Publications
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Relationship between renin-angiotensin-aldosterone system and renal Kir5.1 channels.
(Manis AD, Palygin O, Khedr S, Levchenko V, Hodges MR, Staruschenko A.) Clin Sci (Lond). 2019 Dec 04.
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Progression of diabetic kidney disease in T2DN rats.
(Palygin O, Spires D, Levchenko V, Bohovyk R, Fedoriuk M, Klemens CA, Sykes O, Bukowy JD, Cowley AW Jr, Lazar J, Ilatovskaya DV, Staruschenko A.) Am J Physiol Renal Physiol. 2019 Dec 01;317(6):F1450-F1461.
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Vibrodissociation method for isolation of defined nephron segments from human and rodent kidneys.
(Isaeva E, Fedoriuk M, Bohovyk R, Klemens CA, Khedr S, Golosova D, Levchenko V, El-Meanawy A, Palygin O, Staruschenko A.) Am J Physiol Renal Physiol. 2019 Nov 01;317(5):F1398-F1403.
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(LaDisa JF Jr, Tomita-Mitchell A, Stamm K, Bazan K, Mahnke DK, Goetsch MA, Wegter BJ, Gerringer JW, Repp K, Palygin O, Zietara AP, Krolikowski MM, Eddinger TJ, Alli AA, Mitchell ME.) Physiol Genomics. 2019 06 01;51(6):177-185.
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Role of TRPC6 in Progression of Diabetic Kidney Disease.
(Staruschenko A, Spires D, Palygin O.) Curr Hypertens Rep. 2019 May 21;21(7):48.
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Increased ENaC activity during kidney preservation in Wisconsin solution.
(Khedr S, Palygin O, Pavlov TS, Blass G, Levchenko V, Alsheikh A, Brands MW, El-Meanawy A, Staruschenko A.) BMC Nephrol. 2019 04 29;20(1):145.
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(Puissant MM, Muere C, Levchenko V, Manis AD, Martino P, Forster HV, Palygin O, Staruschenko A, Hodges MR.) FASEB J. 2019 Apr;33(4):5067-5075.
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Postprandial Effects on ENaC-Mediated Sodium Absorption.
(Blass G, Klemens CA, Brands MW, Palygin O, Staruschenko A.) Sci Rep. 2019 Mar 12;9(1):4296.
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(Palygin O, Miller BS, Nishijima Y, Zhang DX, Staruschenko A, Sorokin A.) FASEB J. 2019 02;33(2):2636-2645.
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Fluorescent Imaging and Microscopy for Dynamic Processes in Rats.
(Sandoval RM, Molitoris BA, Palygin O.) Methods Mol Biol. 2019;2018:151-175.
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Characterization of purinergic receptor expression in ARPKD cystic epithelia.
(Palygin O, Ilatovskaya DV, Levchenko V, Klemens CA, Dissanayake L, Williams AM, Pavlov TS, Staruschenko A.) Purinergic Signal. 2018 12;14(4):485-497.
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Protective role of Trpc6 knockout in the progression of diabetic kidney disease.
(Spires D, Ilatovskaya DV, Levchenko V, North PE, Geurts AM, Palygin O, Staruschenko A.) Am J Physiol Renal Physiol. 2018 10 01;315(4):F1091-F1097.