Oleg Palygin, PhD
Assistant Professor
Locations
- Physiology
Contact Information
Biography
Education
PhD, Bogomoletz Institute of Physiology, 2004
MS, Taras Shevchenko National University, 1999
Postdoctoral Scholar, Molecular Physiology and Biophysics, University of Iowa
Postdoctoral Fellow, School of Life Sciences, Warwick University
Research Interests
The capacity of the human kidney to control and regulate cardiovascular health is enormous and has been implicated in many of the physiological factors associated with the general health status. Today, a greater understanding has been achieved of the cellular and molecular mechanisms underlying the processes of renal function, and how these processes may become disordered in chronic kidney disease states such as hypertension, polycystic kidney and diabetes mellitus.
Our laboratory is interested in several aspects of the kidney: its ability to control and regulate body electrolytes, its vulnerability to genetically related mutations, oxidative stress, albuminuria and the role that transport potassium channels, protease activated receptors and the purines like ATP play in these processes.
Publications
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(Puissant MM, Muere C, Levchenko V, Manis AD, Martino P, Forster HV, Palygin O, Staruschenko A, Hodges MR.) FASEB J. 2019 Jan 03:fj201802257R.
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Characterization of purinergic receptor expression in ARPKD cystic epithelia.
(Palygin O, Ilatovskaya DV, Levchenko V, Klemens CA, Dissanayake L, Williams AM, Pavlov TS, Staruschenko A.) Purinergic Signal. 2018 12;14(4):485-497.
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(Palygin O, Miller BS, Nishijima Y, Zhang DX, Staruschenko A, Sorokin A.) FASEB J. 2019 Feb;33(2):2636-2645.
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Protective role of Trpc6 knockout in the progression of diabetic kidney disease.
(Spires D, Ilatovskaya DV, Levchenko V, North PE, Geurts AM, Palygin O, Staruschenko A.) Am J Physiol Renal Physiol. 2018 Oct 01;315(4):F1091-F1097.
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Distal tubule basolateral potassium channels: cellular and molecular mechanisms of regulation.
(Palygin O, Pochynyuk O, Staruschenko A.) Curr Opin Nephrol Hypertens. 2018 Sep;27(5):373-378.
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A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease.
(Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A.) J Am Soc Nephrol. 2018 Jul;29(7):1917-1927.
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Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling.
(Moehring F, Cowie AM, Menzel AD, Weyer AD, Grzybowski M, Arzua T, Geurts AM, Palygin O, Stucky CL.) Elife. 2018 01 16;7.
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Nitric oxide production by glomerular podocytes.
(Palygin O, Ilatovskaya DV, Levchenko V, Endres BT, Geurts AM, Staruschenko A.) Nitric Oxide. 2018 01 30;72:24-31.
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Essential role of Kir5.1 channels in renal salt handling and blood pressure control.
(Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A.) JCI Insight. 2017 Sep 21;2(18).
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(Palygin O, Evans LC, Cowley AW Jr, Staruschenko A.) J Am Heart Assoc. 2017 Sep 12;6(9).
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(Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A.) Front Physiol. 2017;8:227.
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Intravital imaging of the kidney in a rat model of salt-sensitive hypertension.
(Endres BT, Sandoval RM, Rhodes GJ, Campos-Bilderback SB, Kamocka MM, McDermott-Roe C, Staruschenko A, Molitoris BA, Geurts AM, Palygin O.) Am J Physiol Renal Physiol. 2017 Aug 01;313(2):F163-F173.