Bin Pan, MD, PhD

Bin Pan, PhD

Associate Professor

Contact Information

bpan@mcw.edu

Education

MD, Xi'an Jiaotong University, China
PhD, Xi'an Jiaotong University, China
Postdoctoral training, Neurology, University of California at Berkeley
Postdoctoral training, Neuropharmacology, Medical College of Wisconsin

Research Experience

Calcium Channels
Calcium Signaling
Dopamine
Mice
Monoacylglycerol Lipases
Nociceptors
Pain
Peripheral Nerve Injuries
Rats
Synapses
Synaptic Transmission
Thrombospondins

Research Interests

Mechanisms of neuropathic pain
Chronic pain induced depression

Chronic pain is a major public health challenge that is inadequately addressed. The complexity of mechanisms underlying chronic pain includes not only a localized, peripheral disorder, but also widespread central nervous system dysfunction.

In the past, we found that:

The extracellular matrix glycoprotein thrombospondin-4 is increased after nerve injury and this increased TSP4 can regulate voltage activated calcium channels and intracellular calcium signaling in dorsal root ganglion (DRG) neurons
DRG field stimulation can relieve spontaneous and induced neuropathic pain in rats.

In the future, we will investigate changed synaptic transmission in spinal cord and cerebral cortex, which contribute to chronic pain.

Many patients with chronic pain conditions suffer from depression with a prevalence of suicidal ideation. The underlying mechanisms are still unknown. In this project, I will investigate synaptic mechanisms of chronic pain-induced depression with multiple techniques including behavioral tests, in vivo and in vitro brain slice neurophysiological recording, molecular analysis, and genetic engineering

Dorsal root ganglion stimulation of injured sensory neurons in rats rapidly eliminates their spontaneous activity and relieves spontaneous pain.

(Chao D, Mecca CM, Yu G, Segel I, Gold MS, Hogan QH, Pan B.) Pain. 2021 Dec 01;162(12):2917-2932 PMID: 33990112 PMCID: PMC8486885 SCOPUS ID: 2-s2.0-85122047046 05/15/2021
Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression After Neuropathic Pain.

(Mecca CM, Chao D, Yu G, Feng Y, Segel I, Zhang Z, Rodriguez-Garcia DM, Pawela CP, Hillard CJ, Hogan QH, Pan B.) J Neurosci. 2021 09 01;41(35):7492-7508 PMID: 34244365 PMCID: PMC8412994 SCOPUS ID: 2-s2.0-85114152937 07/11/2021
Analgesic Effects of Tonic and Burst Dorsal Root Ganglion Stimulation in Rats With Painful Tibial Nerve Injury.

(Yu G, Segel I, Tran H, Park HJ, Ross E, Hogan QH, Pan B.) Neuromodulation. 2021 Jun 06 PMID: 34096146 PMCID: PMC8645661 06/08/2021
Correction to: Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain.

(Wang SM, Goguadze N, Kimura Y, Yasui Y, Pan B, Wang TY, Nakamura Y, Lin YT, Hogan QH, Wilson KL, Su TP, Wu HE.) Mol Neurobiol. 2021 Jun;58(6):2542 PMID: 33523359 PMCID: PMC8496664 SCOPUS ID: 2-s2.0-85100094553 02/02/2021
Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain.

(Wang SM, Goguadze N, Kimura Y, Yasui Y, Pan B, Wang TY, Nakamura Y, Lin YT, Hogan QH, Wilson KL, Su TP, Wu HE.) Mol Neurobiol. 2021 Jun;58(6):2523-2541 PMID: 33459966 PMCID: PMC8128747 SCOPUS ID: 2-s2.0-85100181606 01/19/2021
Repetitive Mild Traumatic Brain Injury in Rats Impairs Cognition, Enhances Prefrontal Cortex Neuronal Activity, and Reduces Pre-synaptic Mitochondrial Function.

(Feng Y, Li K, Roth E, Chao D, Mecca CM, Hogan QH, Pawela C, Kwok WM, Camara AKS, Pan B.) Front Cell Neurosci. 2021;15:689334 PMID: 34447298 PMCID: PMC8383341 SCOPUS ID: 2-s2.0-85113358817 08/28/2021
Analgesic dorsal root ganglionic field stimulation blocks conduction of afferent impulse trains selectively in nociceptive sensory afferents.

(Chao D, Zhang Z, Mecca CM, Hogan QH, Pan B.) Pain. 2020 12;161(12):2872-2886 PMID: 32658148 PMCID: PMC7669706 SCOPUS ID: 2-s2.0-85096203014 07/14/2020
Satellite glial cells in sensory ganglia express functional transient receptor potential ankyrin 1 that is sensitized in neuropathic and inflammatory pain.

(Shin SM, Itson-Zoske B, Cai Y, Qiu C, Pan B, Stucky CL, Hogan QH, Yu H.) Mol Pain. 2020 Jan-Dec;16:1744806920925425 PMID: 32484015 PMCID: PMC7268132 SCOPUS ID: 2-s2.0-85085909943 06/03/2020
Dorsal Root Ganglion Stimulation Alleviates Pain-related Behaviors in Rats with Nerve Injury and Osteoarthritis.

(Yu G, Segel I, Zhang Z, Hogan QH, Pan B.) Anesthesiology. 2020 08;133(2):408-425 PMID: 32433276 PMCID: PMC8195267 SCOPUS ID: 2-s2.0-85088176994 05/21/2020
AAV-encoded CaV2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain.

(Yu H, Shin SM, Xiang H, Chao D, Cai Y, Xu H, Khanna R, Pan B, Hogan QH.) Gene Ther. 2019 08;26(7-8):308-323 PMID: 31118475 PMCID: PMC6707887 SCOPUS ID: 2-s2.0-85066867179 05/24/2019
Dorsal Root Ganglion Field Stimulation Prevents Inflammation and Joint Damage in a Rat Model of Rheumatoid Arthritis.

(Pan B, Zhang Z, Chao D, Hogan QH.) Neuromodulation. 2018 Apr;21(3):247-253 PMID: 28872725 SCOPUS ID: 2-s2.0-85028826557 09/06/2017
Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons.

(Guo Y, Zhang Z, Wu HE, Luo ZD, Hogan QH, Pan B.) Neuropharmacology. 2017 05 01;117:292-304 PMID: 28232180 PMCID: PMC5414309 SCOPUS ID: 2-s2.0-85013849482 02/25/2017