
Bin Pan, PhD
Associate Professor
Contact Information
Education
PhD, Xi'an Jiaotong University, China
Postdoctoral training, Neurology, University of California at Berkeley
Postdoctoral training, Neuropharmacology, Medical College of Wisconsin
Research Experience
- Calcium Channels
- Calcium Signaling
- Dopamine
- Mice
- Monoacylglycerol Lipases
- Nociceptors
- Pain
- Peripheral Nerve Injuries
- Rats
- Synapses
- Synaptic Transmission
- Thrombospondins
Research Interests
- Mechanisms of neuropathic pain
- Chronic pain induced depression
Chronic pain is a major public health challenge that is inadequately addressed. The complexity of mechanisms underlying chronic pain includes not only a localized, peripheral disorder, but also widespread central nervous system dysfunction.
In the past, we found that:
- The extracellular matrix glycoprotein thrombospondin-4 is increased after nerve injury and this increased TSP4 can regulate voltage activated calcium channels and intracellular calcium signaling in dorsal root ganglion (DRG) neurons
- DRG field stimulation can relieve spontaneous and induced neuropathic pain in rats.
In the future, we will investigate changed synaptic transmission in spinal cord and cerebral cortex, which contribute to chronic pain.
Many patients with chronic pain conditions suffer from depression with a prevalence of suicidal ideation. The underlying mechanisms are still unknown. In this project, I will investigate synaptic mechanisms of chronic pain-induced depression with multiple techniques including behavioral tests, in vivo and in vitro brain slice neurophysiological recording, molecular analysis, and genetic engineering
Publications
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(Chao D, Zhang Z, Mecca CM, Hogan QH, Pan B.) Pain. 2020 12;161(12):2872-2886 PMID: 32658148 PMCID: PMC7669706 SCOPUS ID: 2-s2.0-85096203014 07/14/2020
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(Shin SM, Itson-Zoske B, Cai Y, Qiu C, Pan B, Stucky CL, Hogan QH, Yu H.) Mol Pain. 2020 Jan-Dec;16:1744806920925425 PMID: 32484015 PMCID: PMC7268132 SCOPUS ID: 2-s2.0-85085909943 06/03/2020
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(Yu G, Segel I, Zhang Z, Hogan QH, Pan B.) Anesthesiology. 2020 08;133(2):408-425 PMID: 32433276 SCOPUS ID: 2-s2.0-85088176994 05/21/2020
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(Yu H, Shin SM, Xiang H, Chao D, Cai Y, Xu H, Khanna R, Pan B, Hogan QH.) Gene Ther. 2019 08;26(7-8):308-323 PMID: 31118475 PMCID: PMC6707887 SCOPUS ID: 2-s2.0-85066867179 05/24/2019
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(Pan B, Zhang Z, Chao D, Hogan QH.) Neuromodulation. 2018 Apr;21(3):247-253 PMID: 28872725 SCOPUS ID: 2-s2.0-85028826557 09/06/2017
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(Guo Y, Zhang Z, Wu HE, Luo ZD, Hogan QH, Pan B.) Neuropharmacology. 2017 05 01;117:292-304 PMID: 28232180 PMCID: PMC5414309 SCOPUS ID: 2-s2.0-85013849482 02/25/2017
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Dorsal Root Ganglionic Field Stimulation Relieves Spontaneous and Induced Neuropathic Pain in Rats.
(Pan B, Yu H, Fischer GJ, Kramer JM, Hogan QH.) J Pain. 2016 12;17(12):1349-1358 PMID: 27687223 SCOPUS ID: 2-s2.0-84997525072 10/01/2016
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(Pan B, Guo Y, Wu HE, Park J, Trinh VN, Luo ZD, Hogan QH.) Pain. 2016 09;157(9):2068-2080 PMID: 27168360 PMCID: PMC4988923 SCOPUS ID: 2-s2.0-84984607525 05/12/2016
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CaMKII Controls Whether Touch Is Painful.
(Yu H, Pan B, Weyer A, Wu HE, Meng J, Fischer G, Vilceanu D, Light AR, Stucky C, Rice FL, Hudmon A, Hogan Q.) J Neurosci. 2015 Oct 21;35(42):14086-102 PMID: 26490852 PMCID: PMC4683679 SCOPUS ID: 2-s2.0-84944929761 10/23/2015
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Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia.
(Pan B, Yu H, Park J, Yu YP, Luo ZD, Hogan QH.) J Neurosci Res. 2015 Mar;93(3):443-53 PMID: 25327416 PMCID: PMC4293337 SCOPUS ID: 2-s2.0-84920911767 10/21/2014
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(Hogan QH, Sprick C, Guo Y, Mueller S, Bienengraeber M, Pan B, Wu HE.) Brain Res. 2014 Nov 17;1589:112-25 PMID: 25251590 PMCID: PMC4254330 SCOPUS ID: 2-s2.0-84910127976 09/25/2014
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(Kostic S, Pan B, Guo Y, Yu H, Sapunar D, Kwok WM, Hudmon A, Wu HE, Hogan QH.) Mol Cell Neurosci. 2014 Sep;62:10-8 PMID: 25064143 PMCID: PMC4187344 SCOPUS ID: 2-s2.0-84906053798 07/30/2014