Patricia A Donohoue, MD

Patricia A. Donohoue, MD

Professor & Section Chief, Pediatrics (Endocrinology); Program Director, Endocrine and Diabetes, Children’s Hospital of Wisconsin

Locations

Pediatrics (Endocrinology)

Contact Information

Biography

Board Certifications: American Board of Pediatrics, Pediatrics and Pediatric Endocrinology

Education

MD, The Ohio State University College of Medicine, 1980
Internship, Pediatrics, Columbus Children's Hospital (Nationwide Children's Hospital), Columbus, OH, 1981
Residency, Pediatrics, Rainbow Babies & Child Hospital, Cleveland, OH, 1983
Fellowship, Pediatric Endocrinology, Johns Hopkins Hospital, Baltimore, MD, 1986

Research Interests

Improvement of diabetes care through patient education and clinical care protocols.
Collaboration with McGee Center scientists to maximize patient involvement in human research on Type 1 Diabetes.
Genetics of obesity
Effects of environmental exposures on body composition

As director of the MCW Section of Pediatric Endocrinology and Diabetes, and the CHW Endocrine and Diabetes programs, my major goals are to foster collaborations to maximize the success of research, education, and clinical care within our multidisciplinary team. Involvement with national organizations and federally or privately funded collaborative research efforts are high priorities, as this will allow access to resources and research data beneficial to our own programs. Our nationally recognized Diabetes program scientists will thus be better able to leverage their discoveries to benefit patients and families.

A recurrent p.Arg92Trp variant in steroidogenic factor-1 (NR5A1) can act as a molecular switch in human sex development.

(Bashamboo A, Donohoue PA, Vilain E, Rojo S, Calvel P, Seneviratne SN, Buonocore F, Barseghyan H, Bingham N, Rosenfeld JA, Mulukutla SN, Jain M, Burrage L, Dhar S, Balasubramanyam A, Lee B, Members of UDN, Dumargne MC, Eozenou C, Suntharalingham JP, de Silva K, Lin L, Bignon-Topalovic J, Poulat F, Lagos CF, McElreavey K, Achermann JC.) Hum Mol Genet. 2016 12 01;25(23):5286.
Impact of Age at Diagnosis and Hypothalamic Involvement on Body Mass Index Z-Score Change in Pediatric Brain Tumor Survivors.

(Strobel K, Simpson P, Donohoue PA, Firat S, Jogal S.) Horm Res Paediatr. 2016;85(6):389-95.
Recognition and treatment of concurrent active and neurodegenerative langerhans cell histiocytosis: a case report.

(Ehrhardt MJ, Karst J, Donohoue PA, Maheshwari M, McClain KL, Bingen K, Kelly ME.) J Pediatr Hematol Oncol. 2015 Jan;37(1):e37-40.
Perception and documentation of weight management practices in pediatric primary care.

(Chelvakumar G, Levin L, Polfuss M, Hovis S, Donohoue P, Kotowski A.) WMJ. 2014 Aug;113(4):149-53; quiz 154.
Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations.

(Vallette-Kasic S, Brue T, Pulichino AM, Gueydan M, Barlier A, David M, Nicolino M, Malpuech G, Déchelotte P, Deal C, Van Vliet G, De Vroede M, Riepe FG, Partsch CJ, Sippell WG, Berberoglu M, Atasay B, de Zegher F, Beckers D, Kyllo J, Donohoue P, Fassnacht M, Hahner S, Allolio B, Noordam C, Dunkel L, Hero M, Pigeon B, Weill J, Yigit S, Brauner R, Heinrich JJ, Cummings E, Riddell C, Enjalbert A, Drouin J.) J Clin Endocrinol Metab. 2005 Mar;90(3):1323-31.
A neonatal form of isolated ACTH deficiency frequently associated with Tpit gene mutations.

(Vallette-Kasic S, Pulichino AM, Gueydan M, Barlier A, David M, Malpuech G, Deal C, Van Vliet G, de Vroede M, Riepe F, Partsch CJ, Sippell W, Berberoglu M, Atasay B, de Zegher F, Kyllo J, Donohoue P, Dechelotte P, Fassnacht M, Noordam K, Dunkel L, Pigeon B, Weill J, Yigit S, Brauner R, Leger J, Heinrich JJ, Enjalbert A, Brue T, Drouin J.) Endocr Res. 2004 Nov;30(4):943-4.
Deep venous thrombosis and Turner syndrome.

(Jobe S, Donohoue P, Di Paola J.) J Pediatr Hematol Oncol. 2004 Apr;26(4):272.
Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female.

(Donohoue PA, Tao YX, Collins M, Yeo GS, O'Rahilly S, Segaloff DL.) J Clin Endocrinol Metab. 2003 Dec;88(12):5841-5.
A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference.

(Heo M, Leibel RL, Fontaine KR, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MI, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sørensen TI, Behn P, Permutt MA, Jacobs KB, Elston RC, Hoffman DJ, Gropp E, Allison DB.) Int J Obes Relat Metab Disord. 2002 May;26(5):640-6.
Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity.

(Heo M, Leibel RL, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MI, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sørensen TI, Behn P, Permutt MA, Jacobs KB, Elston RC, Hoffman DJ, Allison DB.) Genetics. 2001 Nov;159(3):1163-78.
Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats.

(Sivitz WI, Fink BD, Morgan DA, Fox JM, Donohoue PA, Haynes WG.) Am J Physiol. 1999 10;277(4):E668-77.
Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression.

(Sivitz WI, Fink BD, Donohoue PA.) Endocrinology. 1999 Apr;140(4):1511-9.