Parasitic flatworms, anthelminthic drug development
Schistosomiasis, a major parasitic disease caused by Schistosoma sp., is found in impoverished communities across the world. Over 200 million people are thought to be suffering from the disease and with schistosomes developing increasing resistance to the current drug of choice, praziquantel (PZQ), the development of novel, or improved, drugs is crucial.
To that end the Chan lab is focusing on understanding the mode of action of PZQ. First released in 1982, PZQ is used in mass drug administration programs worldwide, yet the mode of action is still unclear. Using transcriptomic and functional genetic approaches we aim to identify the mode of action of this drug which will aid in potential development of the drug to combat resistance.