Qi Zhang, PhD

Assistant Professor

Locations

Pharmacology and Toxicology

Contact Information

Biography

General Interests

Lung Cancer and Chemoprevention

Education

PhD, Cell Biology, Lanzhou University, Lanzhou, China, 2006
MS, Biophysics, Lanzhou University, Lanzhou, China, 2003
BS, Biochemistry, Lanzhou University, Lanzhou, China, 1999

Research Interests

Lung cancer is the leading cause of cancer-related deaths in the world. Cancer chemoprevention is an effective approach to reduce the risk of developing cancer. My goal is to find new effective agents and elucidate their mechanisms of action. One of my projects focuses on the state-of-the-art aerosolized technology for lung cancer chemoprevention. Aerosols can increase regional drug delivery to the lungs with lower doses and fewer systemic side effects, avoiding first-pass metabolism of the drug in the liver. Our work demonstrated that aerosol delivery can decrease the toxicity in several novel chemotherapy drugs which showed systematically toxicity. My recent work is using this technology in the prevention study of aerosolized miRNA in lung cancer.

Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine.

(Pan J, Zhang Q, Sei S, Shoemaker RH, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Oct 10;8(47):82689-82699.
Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer.

(Zhang Q, Li R, Chen X, Lee SB, Pan J, Xiong D, Hu J, Miller MS, Szabo E, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Sep 22;8(42):72447-72456.
Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas.

(Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M.) JCI Insight. 2017 Jul 06;2(13).
Rad52 deficiency decreases development of lung squamous cell carcinomas by enhancing immuno-surveillance.

(Lieberman R, Pan J, Zhang Q, You M.) Oncotarget. 2017 May 23;8(21):34032-34044.
Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.

(Pan J, Lee Y, Zhang Q, Xiong D, Wan TC, Wang Y, You M.) Cancer Prev Res (Phila). 2017 Feb;10(2):133-141.
miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1.

(Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, Nevalainen M, Kohli M, Shenoy NK, Meng H, You M, Wang L.) Mol Cancer. 2016 11 10;15(1):70.
Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention.

(Zhang Q, Pan J, Lubet RA, Wang Y, You M.) Mol Carcinog. 2015 Jun;54 Suppl 1:E129-37.
Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro.

(Zhang Q, Pan J, Lubet RA, Komas SM, Kalyanaraman B, Wang Y, You M.) Cancer Prev Res (Phila). 2015 Apr;8(4):318-26.
Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis.

(Zhang Q, Pan J, Wang Y, Lubet R, You M.) Mol Carcinog. 2013 Sep;52(9):686-91.
Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing.

(Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, Starnes S, Yang P, You M.) Carcinogenesis. 2012 Jul;33(7):1270-6.
Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.

(Zhang Q, Pan J, North PE, Yang S, Lubet RA, Wang Y, You M.) Cancer Prev Res (Phila). 2012 May;5(5):717-25.
Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in mice.

(Zhang Q, Pan J, Zhang J, Liu P, Chen R, Chen DR, Lubet R, Wang Y, You M.) Cancer Prev Res (Phila). 2011 Feb;4(2):270-6.

Qi Zhang, PhD

Qi Zhang, PhD

Assistant Professor

Locations

Contact Information

Biography

General Interests

Education

Research Interests

Publications