Qi Zhang, PhD

Assistant Professor

Locations

Pharmacology and Toxicology

Contact Information

General Interests

Lung Cancer and Chemoprevention

Education

PhD, Cell Biology, Lanzhou University, Lanzhou, China, 2006
MS, Biophysics, Lanzhou University, Lanzhou, China, 2003
BS, Biochemistry, Lanzhou University, Lanzhou, China, 1999

Research Interests

Lung cancer is the leading cause of cancer-related deaths in the world. Cancer chemoprevention is an effective approach to reduce the risk of developing cancer. My goal is to find new effective agents and elucidate their mechanisms of action. One of my projects focuses on the state-of-the-art aerosolized technology for lung cancer chemoprevention. Aerosols can increase regional drug delivery to the lungs with lower doses and fewer systemic side effects, avoiding first-pass metabolism of the drug in the liver. Our work demonstrated that aerosol delivery can decrease the toxicity in several novel chemotherapy drugs which showed systematically toxicity. My recent work is using this technology in the prevention study of aerosolized miRNA in lung cancer.

Potentiation of Kras peptide cancer vaccine by avasimibe, a cholesterol modulator.

(Pan J, Zhang Q, Palen K, Wang L, Qiao L, Johnson B, Sei S, Shoemaker RH, Lubet RA, Wang Y, You M.) EBioMedicine. 2019 Nov;49:72-81.
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.

(Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M.) Nat Commun. 2019 05 17;10(1):2205.
Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice.

(Zhang Q, Lee SB, Chen X, Stevenson ME, Pan J, Xiong D, Zhou Y, Miller MS, Lubet RA, Wang Y, Mirza SP, You M.) Nano Lett. 2019 04 10;19(4):2231-2242.
Exosomal miRNAs as Novel Pharmacodynamic Biomarkers for Cancer Chemopreventive Agent Early Stage Treatments in Chemically Induced Mouse Model of Lung Squamous Cell Carcinoma.

(Zhou Y, Zhang Q, Du M, Xiong D, Wang Y, Mohammed A, Lubet RA, Wang L, You M.) Cancers (Basel). 2019 Apr 04;11(4).
Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma.

(Pan J, Xiong D, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M.) Sci Rep. 2018 06 11;8(1):8895.
Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity.

(Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M.) iScience. 2018 May 25;3:192-207.
Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine.

(Pan J, Zhang Q, Sei S, Shoemaker RH, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Oct 10;8(47):82689-82699.
Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer.

(Zhang Q, Li R, Chen X, Lee SB, Pan J, Xiong D, Hu J, Miller MS, Szabo E, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Sep 22;8(42):72447-72456.
Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas.

(Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M.) JCI Insight. 2017 Jul 06;2(13).
Rad52 deficiency decreases development of lung squamous cell carcinomas by enhancing immuno-surveillance.

(Lieberman R, Pan J, Zhang Q, You M.) Oncotarget. 2017 May 23;8(21):34032-34044.
Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.

(Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, You M, Wang Y.) Oncotarget. 2017 Mar 21;8(12):18885-18900.
Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.

(Pan J, Lee Y, Zhang Q, Xiong D, Wan TC, Wang Y, You M.) Cancer Prev Res (Phila). 2017 Feb;10(2):133-141.

Qi Zhang, PhD

Qi Zhang, PhD

Assistant Professor

Locations

Contact Information

General Interests

Education

Research Interests

Publications