PhD, Taras Shevchenko National University of Kyiv, 2015
Research Associate, Bienta, Enamine Ltd., 2012-2016
Research Associate, Pennington Biomedical Research Center, Louisiana State University, 2008-2012
BA, Biology, Taras Shevchenko National University of Kyiv, 2006
Michele A. Battle, PhD
Barrett's esophagus is a serious premalignant condition of the esophagus characterized by columnar metaplasia of the esophageal epithelium. In Barrett’s esophagus, the normal stratified squamous esophageal epithelium changes into a columnar epithelium that resembles the lining of the intestine. Patients with Barrett’s esophagus have a highly elevated risk for esophageal adenocarcinoma, a cancer with an increasing worldwide prevalence and a five-year survival rate of less than 20%. Previous work in our lab, focused on understanding the role of GATA factors in squamocolumnar junction development, suggests involvement of GATA transcription factors in Barrett’s esophagus. My current work is focused on the development of an appropriate mouse model to test the role of GATA factors in development of Barrett’s esophagus. I am also using human esophageal cell culture models and three-dimensional esophageal organoid culture models to study the role of GATA factors in Barrett’s esophagus and esophageal adenocarcinoma.