Dorothee Weihrauch, DVM, PhD

Professor

Contact Information

dorothee@mcw.edu

Education

DVM, Justus Liebig University, Giessen, Germany, 1989
PhD, Max-Planck Institute for Experimental Cardiology, Bad Nauheim, Germany, 1993
Postdoctoral training, Cardiovascular Physiology, Texas A&M, College Station, TX, 1995
Postdoctoral training, Cardiovascular Physiology, Medical College of Wisconsin, 1996

Research Interests

Genetics of cardiomyocyte and cardiac matrix interaction: The HyperGen iPSC Study
Function of myeloperoxidase (MPO) in collateral growth in a model of diabetes
Understanding preeclampsia: Search for novel therapeutic modalities
Small molecule NO precursors as a bioactive source of NO in vasodilation and angiogenesis

Adjuvant doxycycline to enhance anti-amyloid effects: Results from the dual phase 2 trial.

(D'Souza A, Szabo A, Flynn KE, Dhakal B, Chhabra S, Pasquini MC, Weihrauch D, Hari PN.) EClinicalMedicine. 2020 Jun;23:100361 PMID: 32529175 PMCID: PMC7280748 06/13/2020
Intralipid Increases Nitric Oxide Release from Human Endothelial Cells During Oxidative Stress.

(Weihrauch D, Shumpert SD, Larson ME, McVey N, Krolikowski JG, Bamkole O, Riess ML.) JPEN J Parenter Enteral Nutr. 2020 Apr 15 PMID: 32291784 04/16/2020
Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia.

(Weihrauch D, Martin DP, Jones D, Krolikowski J, Struve J, Naylor S, Pritchard KA Jr.) Diab Vasc Dis Res. 2020 Mar-Apr;17(3):1479164120907971 PMID: 32223319 SCOPUS ID: 2-s2.0-85082634881 04/01/2020
PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts.

(Riess ML, Elorbany R, Weihrauch D, Stowe DF, Camara AKS.) Cells. 2020 01 20;9(1) PMID: 31968546 PMCID: PMC7017211 01/24/2020
Corrigendum to Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model [Free Radic. Biol. Med. 113:157-164].

(Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL.) Free Radic Biol Med. 2019 02 01;131:443 PMID: 30581102 SCOPUS ID: 2-s2.0-85058702220 12/26/2018
Wavelength-dependence of vasodilation and NO release from S-nitrosothiols and dinitrosyl iron complexes by far red/near infrared light.

(Keszler A, Lindemer B, Hogg N, Weihrauch D, Lohr NL.) Arch Biochem Biophys. 2018 07 01;649:47-52 PMID: 29752896 SCOPUS ID: 2-s2.0-85047079228 05/13/2018
Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model.

(Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL.) Free Radic Biol Med. 2017 12;113:157-164 PMID: 28935419 PMCID: PMC5699925 SCOPUS ID: 2-s2.0-85030756635 09/25/2017
Lipid emulsion enhances cardiac performance after ischemia-reperfusion in isolated hearts from summer-active arctic ground squirrels.

(Salzman MM, Cheng Q, Deklotz RJ, Dulai GK, Douglas HF, Dikalova AE, Weihrauch D, Barnes BM, Riess ML.) J Comp Physiol B. 2017 Jul;187(5-6):715-724 PMID: 28364393 PMCID: PMC6145465 04/02/2017
Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice.

(Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pagel PS, Lohr NL, Pritchard KA Jr.) J Vis Exp. 2017 03 24(121) PMID: 28362381 PMCID: PMC5408651 SCOPUS ID: 2-s2.0-85017182155 04/01/2017
Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells.

(Gebremedhin D, Zhang DX, Weihrauch D, Uche NN, Harder DR.) PLoS One. 2017;12(5):e0176796 PMID: 28472069 PMCID: PMC5417564 SCOPUS ID: 2-s2.0-85019077900 05/05/2017
An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice.

(Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pillai S, Pagel PS, Lohr NL, Pritchard KA Jr.) PLoS One. 2016;11(4):e0151999 PMID: 27050551 PMCID: PMC4822818 SCOPUS ID: 2-s2.0-84963665146 04/07/2016
Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats.

(Wang H, Weihrauch D, Kersten JR, Toth JM, Passerini AG, Rajamani A, Schrepfer S, LaDisa JF Jr.) Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1130-40 PMID: 26254329 PMCID: PMC4865061 SCOPUS ID: 2-s2.0-84943144084 08/09/2015

Brief Research Summaries

Genetics of cardiomyocyte and cardiac matrix interaction: The HyperGen iPSC Study

This study represents one of the largest collections of existing hiPSC cell lines from an epidemiological study. As part of this project, we study the role and interaction of the cardiac matrix with expression changes on human iPSC-CMs.

Function of myeloperoxidase (MPO) in collateral growth in a model of diabetes

The function of MPO in the development of collateral growth is unknown. We are focusing on the role of MPO in a well-established model of diabetes, the db/db mouse.

Understanding preeclampsia: Novel therapeutic modalities

This study focuses on a better understanding of this multifactorial disease which affects 8% of all pregnant women and has great impact on their cardiovascular health. Our findings point us to different pathways for early and late onset of preeclampsia. We are currently pursuing the benefits of near infrared light (670nm) in this project.

Small molecule NO precursors as a bioactive source of NO in vasodilation and angiogenesis

We have found nitric oxide (NO) precursors in blood and tissues which are stimulated by 670 nm light energy (R/NIR) to release NO and produce a stable NO bound vasodilator. The goal is to assess the impact of these iron and thiol based NO precursors in a chronic model of angiogenesis-rat hindlimb ischemia.

Dorothee Weihrauch, DVM, PhD