
Dorothee Weihrauch, DVM, PhD
Professor
Contact Information
Education
PhD, Max-Planck Institute for Experimental Cardiology, Bad Nauheim, Germany, 1993
Postdoctoral training, Cardiovascular Physiology, Texas A&M, College Station, TX, 1995
Postdoctoral training, Cardiovascular Physiology, Medical College of Wisconsin, 1996
Research Interests
- Genetics of cardiomyocyte and cardiac matrix interaction: The HyperGen iPSC Study
- Function of myeloperoxidase (MPO) in collateral growth in a model of diabetes
- Understanding preeclampsia: Search for novel therapeutic modalities
- Small molecule NO precursors as a bioactive source of NO in vasodilation and angiogenesis
Publications
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Adjuvant doxycycline to enhance anti-amyloid effects: Results from the dual phase 2 trial.
(D'Souza A, Szabo A, Flynn KE, Dhakal B, Chhabra S, Pasquini MC, Weihrauch D, Hari PN.) EClinicalMedicine. 2020 Jun;23:100361 PMID: 32529175 PMCID: PMC7280748 06/13/2020
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Intralipid Increases Nitric Oxide Release from Human Endothelial Cells During Oxidative Stress.
(Weihrauch D, Shumpert SD, Larson ME, McVey N, Krolikowski JG, Bamkole O, Riess ML.) JPEN J Parenter Enteral Nutr. 2020 Apr 15 PMID: 32291784 04/16/2020
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(Weihrauch D, Martin DP, Jones D, Krolikowski J, Struve J, Naylor S, Pritchard KA Jr.) Diab Vasc Dis Res. 2020 Mar-Apr;17(3):1479164120907971 PMID: 32223319 SCOPUS ID: 2-s2.0-85082634881 04/01/2020
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(Riess ML, Elorbany R, Weihrauch D, Stowe DF, Camara AKS.) Cells. 2020 01 20;9(1) PMID: 31968546 PMCID: PMC7017211 01/24/2020
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(Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL.) Free Radic Biol Med. 2019 02 01;131:443 PMID: 30581102 SCOPUS ID: 2-s2.0-85058702220 12/26/2018
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(Keszler A, Lindemer B, Hogg N, Weihrauch D, Lohr NL.) Arch Biochem Biophys. 2018 07 01;649:47-52 PMID: 29752896 SCOPUS ID: 2-s2.0-85047079228 05/13/2018
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(Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL.) Free Radic Biol Med. 2017 12;113:157-164 PMID: 28935419 PMCID: PMC5699925 SCOPUS ID: 2-s2.0-85030756635 09/25/2017
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(Salzman MM, Cheng Q, Deklotz RJ, Dulai GK, Douglas HF, Dikalova AE, Weihrauch D, Barnes BM, Riess ML.) J Comp Physiol B. 2017 Jul;187(5-6):715-724 PMID: 28364393 PMCID: PMC6145465 04/02/2017
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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice.
(Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pagel PS, Lohr NL, Pritchard KA Jr.) J Vis Exp. 2017 03 24(121) PMID: 28362381 PMCID: PMC5408651 SCOPUS ID: 2-s2.0-85017182155 04/01/2017
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(Gebremedhin D, Zhang DX, Weihrauch D, Uche NN, Harder DR.) PLoS One. 2017;12(5):e0176796 PMID: 28472069 PMCID: PMC5417564 SCOPUS ID: 2-s2.0-85019077900 05/05/2017
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(Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pillai S, Pagel PS, Lohr NL, Pritchard KA Jr.) PLoS One. 2016;11(4):e0151999 PMID: 27050551 PMCID: PMC4822818 SCOPUS ID: 2-s2.0-84963665146 04/07/2016
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(Wang H, Weihrauch D, Kersten JR, Toth JM, Passerini AG, Rajamani A, Schrepfer S, LaDisa JF Jr.) Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1130-40 PMID: 26254329 PMCID: PMC4865061 SCOPUS ID: 2-s2.0-84943144084 08/09/2015
Brief Research Summaries
Genetics of cardiomyocyte and cardiac matrix interaction: The HyperGen iPSC Study
This study represents one of the largest collections of existing hiPSC cell lines from an epidemiological study. As part of this project, we study the role and interaction of the cardiac matrix with expression changes on human iPSC-CMs.
Function of myeloperoxidase (MPO) in collateral growth in a model of diabetes
The function of MPO in the development of collateral growth is unknown. We are focusing on the role of MPO in a well-established model of diabetes, the db/db mouse.
Understanding preeclampsia: Novel therapeutic modalities
This study focuses on a better understanding of this multifactorial disease which affects 8% of all pregnant women and has great impact on their cardiovascular health. Our findings point us to different pathways for early and late onset of preeclampsia. We are currently pursuing the benefits of near infrared light (670nm) in this project.
Small molecule NO precursors as a bioactive source of NO in vasodilation and angiogenesis
We have found nitric oxide (NO) precursors in blood and tissues which are stimulated by 670 nm light energy (R/NIR) to release NO and produce a stable NO bound vasodilator. The goal is to assess the impact of these iron and thiol based NO precursors in a chronic model of angiogenesis-rat hindlimb ischemia.