DVM, Justus Liebig University, Giessen, Germany, 1989
PhD, Max-Planck Institute for Experimental Cardiology, Bad Nauheim, Germany, 1993
Postdoctoral training, Cardiovascular Physiology, Texas A&M, College Station, TX, 1995
Postdoctoral training, Cardiovascular Physiology, Medical College of Wisconsin, 1996
- Genetics of cardiomyocyte and cardiac matrix interaction: The HyperGen iPSC Study
- Function of myeloperoxidase (MPO) in collateral growth in a model of diabetes
- Understanding preeclampsia: Search for novel therapeutic modalities
- Small molecule NO precursors as a bioactive source of NO in vasodilation and angiogenesis
(Keszler A, Lindemer B, Hogg N, Weihrauch D, Lohr NL.) Arch Biochem Biophys. 2018 Jul 01;649:47-52.
(Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL.) Free Radic Biol Med. 2017 12;113:157-164.
(Gebremedhin D, Zhang DX, Weihrauch D, Uche NN, Harder DR.) PLoS One. 2017;12(5):e0176796.
(Salzman MM, Cheng Q, Deklotz RJ, Dulai GK, Douglas HF, Dikalova AE, Weihrauch D, Barnes BM, Riess ML.) J Comp Physiol B. 2017 Jul;187(5-6):715-724.
(Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pagel PS, Lohr NL, Pritchard KA Jr.) J Vis Exp. 2017 03 24(121).
(Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pillai S, Pagel PS, Lohr NL, Pritchard KA Jr.) PLoS One. 2016;11(4):e0151999.
(Wang H, Weihrauch D, Kersten JR, Toth JM, Passerini AG, Rajamani A, Schrepfer S, LaDisa JF Jr.) Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1130-40.
(Baotic I, Weihrauch D, Procknow J, Vasquez-Vivar J, Ge ZD, Sudhakaran S, Warltier DC, Kersten JR.) Anesthesiology. 2015 Sep;123(3):582-9.
(Pritchard KA Jr, Weihrauch D.) J Mol Cell Cardiol. 2015 Jul;84:200-1.
(Ninomiya JT, Struve JA, Krolikowski J, Hawkins M, Weihrauch D.) J Biomed Mater Res A. 2015 Jan;103(1):276-81.
(Bangaru ML, Weihrauch D, Tang QB, Zoga V, Hogan Q, Wu HE.) Mol Pain. 2013 Sep 10;9:47.
(Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr.) J Lipid Res. 2013 Nov;54(11):3009-15.
Brief Research Summaries
Genetics of cardiomyocyte and cardiac matrix interaction: The HyperGen iPSC Study
This study represents one of the largest collections of existing hiPSC cell lines from an epidemiological study. As part of this project, we study the role and interaction of the cardiac matrix with expression changes on human iPSC-CMs.
Function of myeloperoxidase (MPO) in collateral growth in a model of diabetes
The function of MPO in the development of collateral growth is unknown. We are focusing on the role of MPO in a well-established model of diabetes, the db/db mouse.
Understanding preeclampsia: Novel therapeutic modalities
This study focuses on a better understanding of this multifactorial disease which affects 8% of all pregnant women and has great impact on their cardiovascular health. Our findings point us to different pathways for early and late onset of preeclampsia. We are currently pursuing the benefits of near infrared light (670nm) in this project.
Small molecule NO precursors as a bioactive source of NO in vasodilation and angiogenesis
We have found nitric oxide (NO) precursors in blood and tissues which are stimulated by 670 nm light energy (R/NIR) to release NO and produce a stable NO bound vasodilator. The goal is to assess the impact of these iron and thiol based NO precursors in a chronic model of angiogenesis-rat hindlimb ischemia.