Yian Wang, MD, PhD

Professor

Contact Information

General Interests

Cancer Prevention

Education

1982, Beijing University School of Medicine, BS/MD - Medicine
1990, Toledo University School of Medicine, PhD - Pathology

Research Interests

There are several strategies in cancer prevention. The major ones include risk management, chemoprevention, and immunoprevention. The risk management is through reduction of exposure to environmental hazardous factors, such as asbestos, tobacco, and alcohol. In order to reduce the risk of, or delay the development or recurrence of cancer, chemoprevention is the use of drugs, vitamins, or other agents; and, immunoprevention is an approach to use vaccines, antibodies, and immune modulators. My research focus is using human cancer models in pre-clinical setting to study the efficacy of drugs and/or vaccines in cancer prevention.

Tumor intrinsic immunity related proteins may be novel tumor suppressors in some types of cancer.

(Xiong D, Wang Y, You M.) Sci Rep. 2019 Jul 29;9(1):10918.
Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice.

(Zhang Q, Lee SB, Chen X, Stevenson ME, Pan J, Xiong D, Zhou Y, Miller MS, Lubet RA, Wang Y, Mirza SP, You M.) Nano Lett. 2019 04 10;19(4):2231-2242.
Exosomal miRNAs as Novel Pharmacodynamic Biomarkers for Cancer Chemopreventive Agent Early Stage Treatments in Chemically Induced Mouse Model of Lung Squamous Cell Carcinoma.

(Zhou Y, Zhang Q, Du M, Xiong D, Wang Y, Mohammed A, Lubet RA, Wang L, You M.) Cancers (Basel). 2019 Apr 04;11(4).
Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer.

(Xiong D, Wang Y, Singavi AK, Mackinnon AC, George B, You M.) iScience. 2018 Nov 30;9:258-277.
Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma.

(Pan J, Xiong D, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M.) Sci Rep. 2018 06 11;8(1):8895.
Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity.

(Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M.) iScience. 2018 May 25;3:192-207.
Novel mutational landscapes and expression signatures of lung squamous cell carcinoma.

(Xiong D, Pan J, Yin Y, Jiang H, Szabo E, Lubet RA, Wang Y, You M.) Oncotarget. 2018 Jan 26;9(7):7424-7441.
Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine.

(Pan J, Zhang Q, Sei S, Shoemaker RH, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Oct 10;8(47):82689-82699.
Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer.

(Zhang Q, Li R, Chen X, Lee SB, Pan J, Xiong D, Hu J, Miller MS, Szabo E, Lubet RA, Wang Y, You M.) Oncotarget. 2017 Sep 22;8(42):72447-72456.
Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas.

(Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M.) JCI Insight. 2017 Jul 06;2(13).
Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.

(Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, You M, Wang Y.) Oncotarget. 2017 Mar 21;8(12):18885-18900.
Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.

(Pan J, Lee Y, Zhang Q, Xiong D, Wan TC, Wang Y, You M.) Cancer Prev Res (Phila). 2017 Feb;10(2):133-141.

Yian Wang, MD, PhD

Yian Wang, MD, PhD

Professor

Contact Information

General Interests

Education

Research Interests

Publications