
Yong Liu, PhD
Assistant Professor
Locations
- Physiology
Contact Information
Education
PhD, Genetics, Chinese Academy of Sciences, Beijing, China, 2005
Research Interests
With Dahl salt sensitive rats as a model, we have shown that important genes such as 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) (PMID: 18826995, 18716005) and fumarate hydratase 1 (Fh1) (PMID: 19546378) contribute to the development of hypertension and renal damage.
microRNAs (miRNAs) are small non-coding endogenous RNAs that can regulate gene expression post-transcriptionally through binding with the 3-UTR region of mRNA. Through targeting a large set of collagens and collagen related genes, miRNA-29 plays a critical role in the regulation of renal medullary fibrosis (PMID: 20194304). Renal miR-214 plays a functional and potentially genetic role in the development of hypertension through targeting endothelial nitric oxide synthase (eNOS) (PMID: 30049682).
Data from twin studies suggest that there are only 25% to 68% heritability of systolic/diastolic blood pressure and hypertension. Epigenetics, such as DNA methylation, which change gene expression without altering the genomic DNA, has been shown to play important role in determining an individual’s risk of hypertension. With a modified Reduced-Representation Bisulfite Sequencing (RRBS) technique, we established the first base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in hypertension (PMID: 24420542). Our recent study provided evidence that DNA de novo (de)methylation in the kidney contributes to salt-induced hypertension (in press).
Building on these findings and experience, my current research continues to explore genetic, epigenetic and molecular mechanisms of hypertension and other diseases.
Publications
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miR-204: Molecular Regulation and Role in Cardiovascular and Renal Diseases.
(Liu J, Liu Y, Wang F, Liang M.) Hypertension. 2021 08;78(2):270-281 PMID: 34176282 PMCID: PMC8283800 SCOPUS ID: 2-s2.0-85109560313 06/29/2021
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Dietary Sodium Restriction Results in Tissue-Specific Changes in DNA Methylation in Humans.
(Kidambi S, Pan X, Yang C, Liu P, Roberts ML, Li Y, Wang T, Laud PW, Liu Y, Rubens M, Thomas R, Widlansky ME, Beyer AM, Liu Y, Cowley AW Jr, Kotchen TA, Munyura Y, Moosreiner A, Mattson DL, Liang M.) Hypertension. 2021 08;78(2):434-446 PMID: 34120454 SCOPUS ID: 2-s2.0-85109563974 06/15/2021
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Transfer RNA Fragments in the Kidney in Hypertension.
(Pan X, Geng X, Liu Y, Yu M, Mishra MK, Xu X, Ding X, Liu P, Liang M.) Hypertension. 2021 05 05;77(5):1627-1637 PMID: 33775129 PMCID: PMC8370717 SCOPUS ID: 2-s2.0-85104047516 03/30/2021
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(Sun X, Yi J, Yang J, Han Y, Qian X, Liu Y, Li J, Lu B, Zhang J, Pan X, Liu Y, Liang M, Chen E, Liu P, Lu Y.) Theranostics. 2021;11(11):5346-5364 PMID: 33859751 PMCID: PMC8039961 SCOPUS ID: 2-s2.0-85102449346 04/17/2021
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(Sun X, Yang J, Yu M, Yao D, Zhou L, Li X, Qiu Q, Lin W, Lu B, Chen E, Wang P, Chen W, Tao S, Xu H, Williams A, Liu Y, Pan X, Cowley AW Jr, Lu W, Liang M, Liu P, Lu Y.) NAR Cancer. 2020 Dec;2(4):zcaa031 PMID: 34316691 PMCID: PMC8210304 07/29/2021
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(Liu Y, Han Y, Zhou L, Pan X, Sun X, Liu Y, Liang M, Qin J, Lu Y, Liu P.) Genomics. 2020 11;112(6):4567-4576 PMID: 32712292 SCOPUS ID: 2-s2.0-85089382545 07/28/2020
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OncotRF: an online resource for exploration of tRNA-derived fragments in human cancers.
(Yao D, Sun X, Zhou L, Amanullah M, Pan X, Liu Y, Liang M, Liu P, Lu Y.) RNA Biol. 2020 08;17(8):1081-1091 PMID: 32597311 PMCID: PMC7577240 SCOPUS ID: 2-s2.0-85087512616 07/01/2020
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Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes.
(Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker MA, Yin J, Wu R, Liu X, Regner KR, Usa K, Liu Y, Zhang C, Dong L, Geurts AM, Wang N, Miller SS, He Y, Liang M.) J Am Soc Nephrol. 2020 07;31(7):1539-1554 PMID: 32487559 PMCID: PMC7350998 SCOPUS ID: 2-s2.0-85087468924 06/04/2020
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(Mishra MK, Liang EY, Geurts AM, Auer PWL, Liu P, Rao S, Greene AS, Liang M, Liu Y.) Hypertension. 2020 03;75(3):859-868 PMID: 31902252 PMCID: PMC7035167 SCOPUS ID: 2-s2.0-85081142576 01/07/2020
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(Geng X, Song N, Zhao S, Xu J, Liu Y, Fang Y, Liang M, Xu X, Ding X.) Cell Death Discov. 2020;6:19 PMID: 32257391 PMCID: PMC7118150 SCOPUS ID: 2-s2.0-85083166086 04/08/2020
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Functional role of epigenetic regulation in the development of prenatal programmed hypertension.
(Liu Y, Liang M.) Kidney Int. 2019 07;96(1):10-12 PMID: 31229025 SCOPUS ID: 2-s2.0-85066848304 06/24/2019
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(Liu Y, Kriegel AJ, Liang M.) Methods Mol Biol. 2019;2018:177-194 PMID: 31228157 SCOPUS ID: 2-s2.0-85068180336 06/23/2019