
Yong Liu, PhD
Assistant Professor
Locations
- Physiology
Contact Information
Education
PhD, Genetics, Chinese Academy of Sciences, Beijing, China, 2005
Research Interests
With Dahl salt sensitive rats as a model, we have shown that important genes such as 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) (PMID: 18826995, 18716005) and fumarate hydratase 1 (Fh1) (PMID: 19546378) contribute to the development of hypertension and renal damage.
microRNAs (miRNAs) are small non-coding endogenous RNAs that can regulate gene expression post-transcriptionally through binding with the 3-UTR region of mRNA. Through targeting a large set of collagens and collagen related genes, miRNA-29 plays a critical role in the regulation of renal medullary fibrosis (PMID: 20194304). Renal miR-214 plays a functional and potentially genetic role in the development of hypertension through targeting endothelial nitric oxide synthase (eNOS) (PMID: 30049682).
Data from twin studies suggest that there are only 25% to 68% heritability of systolic/diastolic blood pressure and hypertension. Epigenetics, such as DNA methylation, which change gene expression without altering the genomic DNA, has been shown to play important role in determining an individual’s risk of hypertension. With a modified Reduced-Representation Bisulfite Sequencing (RRBS) technique, we established the first base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in hypertension (PMID: 24420542). Our recent study provided evidence that DNA de novo (de)methylation in the kidney contributes to salt-induced hypertension (in press).
Building on these findings and experience, my current research continues to explore genetic, epigenetic and molecular mechanisms of hypertension and other diseases.
Publications
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(Mishra MK, Liang EY, Geurts AM, Auer PWL, Liu P, Rao S, Greene AS, Liang M, Liu Y.) Hypertension. 2020 Mar;75(3):859-868 PMID: 31902252 PMCID: PMC7035167 SCOPUS ID: 2-s2.0-85081142576 01/07/2020
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Functional role of epigenetic regulation in the development of prenatal programmed hypertension.
(Liu Y, Liang M.) Kidney Int. 2019 07;96(1):10-12 PMID: 31229025 SCOPUS ID: 2-s2.0-85066848304 06/24/2019
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Long Noncoding RNA: Genomics and Relevance to Physiology.
(Kong Y, Lu Z, Liu P, Liu Y, Wang F, Liang EY, Hou FF, Liang M.) Compr Physiol. 2019 06 12;9(3):933-946 PMID: 31187897 SCOPUS ID: 2-s2.0-85067798712 06/13/2019
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MiR-192-5p in the Kidney Protects Against the Development of Hypertension.
(Baker MA, Wang F, Liu Y, Kriegel AJ, Geurts AM, Usa K, Xue H, Wang D, Kong Y, Liang M.) Hypertension. 2019 02;73(2):399-406 PMID: 30595117 PMCID: PMC6339564 SCOPUS ID: 2-s2.0-85059796489 01/01/2019
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(Liu Y, Kriegel AJ, Liang M.) Methods Mol Biol. 2019;2018:177-194 PMID: 31228157 SCOPUS ID: 2-s2.0-85068180336 06/23/2019
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MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury.
(Wei Q, Sun H, Song S, Liu Y, Liu P, Livingston MJ, Wang J, Liang M, Mi QS, Huo Y, Nahman NS, Mei C, Dong Z.) J Clin Invest. 2018 12 03;128(12):5448-5464 PMID: 30325740 PMCID: PMC6264638 SCOPUS ID: 2-s2.0-85058349510 10/17/2018
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Role of DNA De Novo (De)Methylation in the Kidney in Salt-Induced Hypertension.
(Liu P, Liu Y, Liu H, Pan X, Li Y, Usa K, Mishra MK, Nie J, Liang M.) Hypertension. 2018 11;72(5):1160-1171 PMID: 30354815 PMCID: PMC6314686 SCOPUS ID: 2-s2.0-85055596895 10/26/2018
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MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension.
(Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M.) J Am Soc Nephrol. 2018 10;29(10):2518-2528 PMID: 30049682 PMCID: PMC6171279 SCOPUS ID: 2-s2.0-85053979457 07/28/2018
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Tissue-specific effects of targeted mutation of Mir29b1 in rats.
(Xue H, Zhang G, Geurts AM, Usa K, Jensen DM, Liu Y, Widlansky ME, Liang M.) EBioMedicine. 2018 Sep;35:260-269 PMID: 30120082 PMCID: PMC6156712 SCOPUS ID: 2-s2.0-85051562841 08/19/2018
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(Sun X, Han Y, Zhou L, Chen E, Lu B, Liu Y, Pan X, Cowley AW Jr, Liang M, Wu Q, Lu Y, Liu P.) Bioinformatics. 2018 08 15;34(16):2715-2723 PMID: 29579198 SCOPUS ID: 2-s2.0-85055129630 03/27/2018
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(Li Y, Pan X, Roberts ML, Liu P, Kotchen TA, Cowley AW Jr, Mattson DL, Liu Y, Liang M, Kidambi S.) Epigenomics. 2018 06;10(6):797-811 PMID: 29683333 SCOPUS ID: 2-s2.0-85049644277 04/24/2018
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Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet.
(Cheng Y, Song H, Pan X, Xue H, Wan Y, Wang T, Tian Z, Hou E, Lanza IR, Liu P, Liu Y, Laud PW, Usa K, He Y, Liang M.) Theranostics. 2018;8(6):1468-1480 PMID: 29556335 PMCID: PMC5858161 SCOPUS ID: 2-s2.0-85041571500 03/21/2018