Yu-Chieh (Jack) Wang, PhD

Assistant Professor

Locations

TBRC 3885 (Office)
TBRC 3698 and 3645 (Lab)

Contact Information

General Interests

Cancer biology, stem cell biology, regenerative medicine, systems biology, glycobiology, experimental therapeutics

Education

PhD, Pharmacy (Medicinal Chemistry and Pharmacognosy), Ohio State University, Columbus, OH, 2008
BS, Department of Biology, National Taiwan Normal University, Taipei, Taiwan, 2002
Postdoctoral Research, The Scripps Research Institute, 2009-2014

Learn more about the Wang Lab

Biography

Dr. Wang received his doctoral degree in medicinal chemistry and pharmacognosy from The Ohio State University. His early research was focused on the experimental therapeutics of human cancer and the regulation of kinase signaling using novel small molecules. In addition, he has led several studies at the interface of stem cell and cancer biology with emphases on posttranslational modification-mediated regulatory mechanisms underlying cellular pluripotency and the physio-pathological development of human pigment cells. As an American Cancer Society Research Scholar, Dr. Wang works with his group to provide new insights and resolutions to help overcome challenges in biomedical research and disease treatment. Using human stem cell-based platforms and studying regenerative medicine, they strive to have a better understanding of how these novel approaches can be leveraged to model or treat disease.

Honors and Awards

2020 American Cancer Society (ACS) Research Scholar, American Cancer Society
2012 Society of Fellows Postdoctoral Travel Award, The Scripps Research Institute
2011 ISSCR Travel Award, International Society for Stem Cell Research (ISSCR)
2009 Marie Mayer Fellow, Marie & Jimmy Mayer Award for Melanoma Research
2007 NIH National Graduate Student Research Festival Travel Grant, National Institutes of Health
2004 Outstanding Student Research Award, Department of Biology, National Taiwan Normal University
2002 Outstanding Student Research Award, Department of Biology, National Taiwan Normal University

Research Experience

Antineoplastic Agents
Cell Survival
Cellular Reprogramming
Combined Modality Therapy
Congenital Disorders of Glycosylation
Developmental Biology
Endoplasmic Reticulum Stress
Gene Expression Regulation, Developmental
Glioblastoma
Glycosyltransferases
Human Embryonic Stem Cells
Induced Pluripotent Stem Cells

Methodologies and Techniques

Cell Line, Tumor
Cellular Reprogramming Techniques
CRISPR-Cas Systems
Culture Techniques
Drug Screening Assays, Antitumor
Gene Expression Profiling
Glycomics
Microarray Analysis
Models, Animal
Pluripotent Stem Cells
Proteomics
Single-Cell Analysis

Research Interests

Having my initial training as a cancer biologist followed by postdoctoral research in pluripotent stem cells and regenerative medicine, I am leading my research group to actively work at the interface of cancer and stem cell biology. We have established and leveraged cutting-edge platforms and approaches, including human pluripotent stem cells (hPSCs), cerebral organoids, animal models, gene editing, and systems biology techniques, to investigate signaling networks, neurodevelopmental abnormalities, and anticancer responses relevant to the alterations of glycoenzymes. We also maintain a long-standing interest in dissecting molecular mechanisms underlying the regulation of cellular pluripotency and differentiation in hPSCs, aiming to better harness hPSCs for regenerative medicine and disease modeling.

Urine Sample-Derived Cerebral Organoids Suitable for Studying Neurodevelopment and Pharmacological Responses.

(Lin VJT, Hu J, Zolekar A, Yan LJ, Wang YC.) Front Cell Dev Biol. 2020;8:304 PMID: 32528947 PMCID: PMC7247822 06/13/2020
On-chip multiplexed single-cell pattern and controllable intracellular delivery

(Dong, Z., Jiao, Y., Hao, Y., Wang, P., Liu, Y., Shi, J., Chitrakar, C., Black, S., Wang, Y.-C., Lee, L.J., Li, M., Fan, Y., Chang, L..) Microsystems & Nanoengineering. 02/24/2020
Wearable Devices for Single-Cell Sensing and Transfection.

(Chang L, Wang YC, Ershad F, Yang R, Yu C, Fan Y.) Trends Biotechnol. 2019 11;37(11):1175-1188 PMID: 31072609 SCOPUS ID: 2-s2.0-85065091597 05/11/2019
Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain.

(Zuo Z, Zolekar A, Babu K, Lin VJ, Hayatshahi HS, Rajan R, Wang YC, Liu J.) Elife. 2019 07 30;8 PMID: 31361218 PMCID: PMC6706240 SCOPUS ID: 2-s2.0-85071706842 07/31/2019
Bioinspired Nanoparticles Engineered for Enhanced Delivery to the Bone

(Gdowski AS, Lampe JB, Lin VJT, Joshi R, Wang YC, Mukerjee A, Vishwanatha JK, Ranjan AP.) ACS Applied Nano Materials. 25 October 2019;2(10):6249-6257 SCOPUS ID: 2-s2.0-85074676172 10/25/2019
Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1.

(Zolekar A, Lin VJT, Mishra NM, Ho YY, Hayatshahi HS, Parab A, Sampat R, Liao X, Hoffmann P, Liu J, Emmitte KA, Wang YC.) Br J Cancer. 2018 12;119(12):1538-1551 PMID: 30385822 PMCID: PMC6288164 SCOPUS ID: 2-s2.0-85055978337 11/06/2018
Potassium as a pluripotency-associated element identified through inorganic element profiling in human pluripotent stem cells.

(Lin VJT, Zolekar A, Shi Y, Koneru B, Dimitrijevich S, Di Pasqua AJ, Wang YC.) Sci Rep. 2017 07 10;7(1):5005 PMID: 28694442 PMCID: PMC5504050 SCOPUS ID: 2-s2.0-85023172089 07/12/2017
New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells.

(O'Brien CM, Chy HS, Zhou Q, Blumenfeld S, Lambshead JW, Liu X, Kie J, Capaldo BD, Chung TL, Adams TE, Phan T, Bentley JD, McKinstry WJ, Oliva K, McMurrick PJ, Wang YC, Rossello FJ, Lindeman GJ, Chen D, Jarde T, Clark AT, Abud HE, Visvader JE, Nefzger CM, Polo JM, Loring JF, Laslett AL.) Stem Cells. 2017 03;35(3):626-640 PMID: 28009074 PMCID: PMC5412944 SCOPUS ID: 2-s2.0-85016602811 12/23/2016
Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications.

(Mull AN, Zolekar A, Wang YC.) Int J Mol Sci. 2015 Dec 21;16(12):30458-69 PMID: 26703580 PMCID: PMC4691150 SCOPUS ID: 2-s2.0-84951311009 12/26/2015
Tetracycline-Containing MCM-41 Mesoporous Silica Nanoparticles for the Treatment of Escherichia coli.

(Koneru B, Shi Y, Wang YC, Chavala SH, Miller ML, Holbert B, Conson M, Ni A, Di Pasqua AJ.) Molecules. 2015 Oct 30;20(11):19690-8 PMID: 26528964 PMCID: PMC6332305 SCOPUS ID: 2-s2.0-84949948608 11/04/2015
Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells.

(Wang YC, Stein JW, Lynch CL, Tran HT, Lee CY, Coleman R, Hatch A, Antontsev VG, Chy HS, O'Brien CM, Murthy SK, Laslett AL, Peterson SE, Loring JF.) Sci Rep. 2015 Aug 25;5:13317 PMID: 26304831 PMCID: PMC4548446 SCOPUS ID: 2-s2.0-84940042013 08/26/2015
The 'sweet' spot of cellular pluripotency: protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine.

(Wang YC, Lin V, Loring JF, Peterson SE.) Expert Opin Biol Ther. 2015 May;15(5):679-87 PMID: 25736263 SCOPUS ID: 2-s2.0-84927617058 03/05/2015

Yu-Chieh (Jack) Wang, PhD