
Yu-Chieh (Jack) Wang, PhD
Assistant Professor
Locations
- TBRC 3885 (Office)
TBRC 3698 and 3645 (Lab)
Contact Information
General Interests
Education
BS, Department of Biology, National Taiwan Normal University, Taipei, Taiwan, 2002
Postdoctoral Research, The Scripps Research Institute, 2009-2014
Biography
Dr. Wang received his doctoral degree in medicinal chemistry and pharmacognosy from The Ohio State University. His early research was focused on the experimental therapeutics of human cancer and the regulation of kinase signaling using novel small molecules. In addition, he has led several studies at the interface of stem cell and cancer biology with emphases on posttranslational modification-mediated regulatory mechanisms underlying cellular pluripotency and the physio-pathological development of human pigment cells. As an American Cancer Society Research Scholar, Dr. Wang works with his group to provide new insights and resolutions to help overcome challenges in biomedical research and disease treatment. Using human stem cell-based platforms and studying regenerative medicine, they strive to have a better understanding of how these novel approaches can be leveraged to model or treat disease.
Honors and Awards
- 2020 American Cancer Society (ACS) Research Scholar, American Cancer Society
- 2012 Society of Fellows Postdoctoral Travel Award, The Scripps Research Institute
- 2011 ISSCR Travel Award, International Society for Stem Cell Research (ISSCR)
- 2009 Marie Mayer Fellow, Marie & Jimmy Mayer Award for Melanoma Research
- 2007 NIH National Graduate Student Research Festival Travel Grant, National Institutes of Health
- 2004 Outstanding Student Research Award, Department of Biology, National Taiwan Normal University
- 2002 Outstanding Student Research Award, Department of Biology, National Taiwan Normal University
Research Experience
- Antineoplastic Agents
- Cell Survival
- Cellular Reprogramming
- Combined Modality Therapy
- Congenital Disorders of Glycosylation
- Developmental Biology
- Endoplasmic Reticulum Stress
- Gene Expression Regulation, Developmental
- Glioblastoma
- Glycosyltransferases
- Human Embryonic Stem Cells
- Induced Pluripotent Stem Cells
Methodologies and Techniques
- Cell Line, Tumor
- Cellular Reprogramming Techniques
- CRISPR-Cas Systems
- Culture Techniques
- Drug Screening Assays, Antitumor
- Gene Expression Profiling
- Glycomics
- Microarray Analysis
- Models, Animal
- Pluripotent Stem Cells
- Proteomics
- Single-Cell Analysis
Research Interests
Having my initial training as a cancer biologist followed by postdoctoral research in pluripotent stem cells and regenerative medicine, I am leading my research group to actively work at the interface of cancer and stem cell biology. We have established and leveraged cutting-edge platforms and approaches, including human pluripotent stem cells (hPSCs), cerebral organoids, animal models, gene editing, and systems biology techniques, to investigate signaling networks, neurodevelopmental abnormalities, and anticancer responses relevant to the alterations of glycoenzymes. We also maintain a long-standing interest in dissecting molecular mechanisms underlying the regulation of cellular pluripotency and differentiation in hPSCs, aiming to better harness hPSCs for regenerative medicine and disease modeling.
Publications
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(Lin VJT, Hu J, Zolekar A, Yan LJ, Wang YC.) Front Cell Dev Biol. 2020;8:304 PMID: 32528947 PMCID: PMC7247822 06/13/2020
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On-chip multiplexed single-cell pattern and controllable intracellular delivery
(Dong, Z., Jiao, Y., Hao, Y., Wang, P., Liu, Y., Shi, J., Chitrakar, C., Black, S., Wang, Y.-C., Lee, L.J., Li, M., Fan, Y., Chang, L..) Microsystems & Nanoengineering. 02/24/2020
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Wearable Devices for Single-Cell Sensing and Transfection.
(Chang L, Wang YC, Ershad F, Yang R, Yu C, Fan Y.) Trends Biotechnol. 2019 11;37(11):1175-1188 PMID: 31072609 SCOPUS ID: 2-s2.0-85065091597 05/11/2019
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(Zuo Z, Zolekar A, Babu K, Lin VJ, Hayatshahi HS, Rajan R, Wang YC, Liu J.) Elife. 2019 07 30;8 PMID: 31361218 PMCID: PMC6706240 SCOPUS ID: 2-s2.0-85071706842 07/31/2019
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Bioinspired Nanoparticles Engineered for Enhanced Delivery to the Bone
(Gdowski AS, Lampe JB, Lin VJT, Joshi R, Wang YC, Mukerjee A, Vishwanatha JK, Ranjan AP.) ACS Applied Nano Materials. 25 October 2019;2(10):6249-6257 SCOPUS ID: 2-s2.0-85074676172 10/25/2019
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(Zolekar A, Lin VJT, Mishra NM, Ho YY, Hayatshahi HS, Parab A, Sampat R, Liao X, Hoffmann P, Liu J, Emmitte KA, Wang YC.) Br J Cancer. 2018 12;119(12):1538-1551 PMID: 30385822 PMCID: PMC6288164 SCOPUS ID: 2-s2.0-85055978337 11/06/2018
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(Lin VJT, Zolekar A, Shi Y, Koneru B, Dimitrijevich S, Di Pasqua AJ, Wang YC.) Sci Rep. 2017 07 10;7(1):5005 PMID: 28694442 PMCID: PMC5504050 SCOPUS ID: 2-s2.0-85023172089 07/12/2017
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New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells.
(O'Brien CM, Chy HS, Zhou Q, Blumenfeld S, Lambshead JW, Liu X, Kie J, Capaldo BD, Chung TL, Adams TE, Phan T, Bentley JD, McKinstry WJ, Oliva K, McMurrick PJ, Wang YC, Rossello FJ, Lindeman GJ, Chen D, Jarde T, Clark AT, Abud HE, Visvader JE, Nefzger CM, Polo JM, Loring JF, Laslett AL.) Stem Cells. 2017 03;35(3):626-640 PMID: 28009074 PMCID: PMC5412944 SCOPUS ID: 2-s2.0-85016602811 12/23/2016
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Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications.
(Mull AN, Zolekar A, Wang YC.) Int J Mol Sci. 2015 Dec 21;16(12):30458-69 PMID: 26703580 PMCID: PMC4691150 SCOPUS ID: 2-s2.0-84951311009 12/26/2015
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(Koneru B, Shi Y, Wang YC, Chavala SH, Miller ML, Holbert B, Conson M, Ni A, Di Pasqua AJ.) Molecules. 2015 Oct 30;20(11):19690-8 PMID: 26528964 PMCID: PMC6332305 SCOPUS ID: 2-s2.0-84949948608 11/04/2015
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(Wang YC, Stein JW, Lynch CL, Tran HT, Lee CY, Coleman R, Hatch A, Antontsev VG, Chy HS, O'Brien CM, Murthy SK, Laslett AL, Peterson SE, Loring JF.) Sci Rep. 2015 Aug 25;5:13317 PMID: 26304831 PMCID: PMC4548446 SCOPUS ID: 2-s2.0-84940042013 08/26/2015
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(Wang YC, Lin V, Loring JF, Peterson SE.) Expert Opin Biol Ther. 2015 May;15(5):679-87 PMID: 25736263 SCOPUS ID: 2-s2.0-84927617058 03/05/2015