Jesse G. Meyer, PhD

Assistant Professor

Locations

Biochemistry
BSB 376E

Contact Information

General Interests

Modeling biological and chemical systems to predict new drugs in silico, working with the interface of mass spectrometry-based omics (proteomics, metabolomics, lipidomics) and computation (bioinformatics, machine learning).

Education

PhD, Chemistry - Specialization in Multi-scale Biology, University of California, San Diego, 2015
MS, Chemistry, University of California, San Diego, 2012
BS, Biochemistry - Chemistry Minor, University of Minnesota - Twin Cities, 2009

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Biography

Jesse received his Bachelor of Science degree in Biochemistry from the University of Minnesota in 2009. He then worked as a junior scientist in a plant metabolomics lab for a year while applying for graduate school. He began his PhD studies in Chemistry at the University of California, San Diego, and graduated in spring of 2015. In San Diego, he developed new methods to increase the observable proteome. To learn more about the biology of metabolism and aging, he started a postdoctoral position at the Buck Institute for Research on Aging in 2015. During this time, Jesse published a number of papers on methods for study of protein acylation. In summer 2018, he left the Buck Institute to do a second postdoctoral fellowship at the University of Wisconsin, Madison. Here he developed skills in machine learning and built a method for ultrafast proteome analysis. He started as Assistant Professor at the Medical College of Wisconsin in August 2020.

Dr. Meyer teaches in the following graduate-level courses: Techniques in Molecular and Cellular Biology (16242), Biophysical Techniques in Biochemistry (03226/02226).

Research Experience

Acetyl Coenzyme A
Acetylation
Acylation
Amino Acid Sequence
Energy Metabolism
Escherichia coli
Glucose
Liver
Lysine
Machine Learning
Mass Spectrometry
metabolism

Methodologies and Techniques

Acetylation
Acylation
Mass Spectrometry
Mitochondria
Mitochondrial Proteins
Peptides
Protein Processing, Post-Translational
Proteins
Proteome
Proteomics
Serine Endopeptidases
Sirtuins

Peptide Correlation Analysis (PeCorA) Reveals Differential Proteoform Regulation.

(Dermit M, Peters-Clarke TM, Shishkova E, Meyer JG.) J Proteome Res. 2021 04 02;20(4):1972-1980 PMID: 33325715 12/17/2020
Large-Scale Multi-omic Analysis of COVID-19 Severity.

(Overmyer KA, Shishkova E, Miller IJ, Balnis J, Bernstein MN, Peters-Clarke TM, Meyer JG, Quan Q, Muehlbauer LK, Trujillo EA, He Y, Chopra A, Chieng HC, Tiwari A, Judson MA, Paulson B, Brademan DR, Zhu Y, Serrano LR, Linke V, Drake LA, Adam AP, Schwartz BS, Singer HA, Swanson S, Mosher DF, Stewart R, Coon JJ, Jaitovich A.) Cell Syst. 2021 01 20;12(1):23-40.e7 PMID: 33096026 PMCID: PMC7543711 10/24/2020
Qualitative and Quantitative Shotgun Proteomics Data Analysis from Data-Dependent Acquisition Mass Spectrometry.

(Meyer JG.) Methods Mol Biol. 2021;2259:297-308 PMID: 33687723 03/10/2021
Quantitative shotgun proteome analysis by direct infusion.

(Meyer JG, Niemi NM, Pagliarini DJ, Coon JJ.) Nat Methods. 2020 12;17(12):1222-1228 PMID: 33230323 PMCID: PMC8009190 11/25/2020
SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.

(Gut P, Matilainen S, Meyer JG, Pällijeff P, Richard J, Carroll CJ, Euro L, Jackson CB, Isohanni P, Minassian BA, Alkhater RA, Østergaard E, Civiletto G, Parisi A, Thevenet J, Rardin MJ, He W, Nishida Y, Newman JC, Liu X, Christen S, Moco S, Locasale JW, Schilling B, Suomalainen A, Verdin E.) Nat Commun. 2020 11 23;11(1):5927 PMID: 33230181 PMCID: PMC7684291 11/25/2020
Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species.

(Meyer JG, Garcia TY, Schilling B, Gibson BW, Lamba DA.) Sci Rep. 2019 10 28;9(1):15440 PMID: 31659173 PMCID: PMC6817852 10/30/2019
Learning Drug Functions from Chemical Structures with Convolutional Neural Networks and Random Forests.

(Meyer JG, Liu S, Miller IJ, Coon JJ, Gitter A.) J Chem Inf Model. 2019 10 28;59(10):4438-4449 PMID: 31518132 PMCID: PMC6819987 09/14/2019
Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.

(Softic S, Meyer JG, Wang GX, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, Cohen DE, Kahn CR.) Cell Metab. 2019 10 01;30(4):735-753.e4 PMID: 31577934 PMCID: PMC7816129 10/03/2019
Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.

(Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR.) Mol Cell. 2019 05 16;74(4):844-857.e7 PMID: 31000437 PMCID: PMC6525068 04/20/2019
Correction for Christensen et al., Identification of Novel Protein Lysine Acetyltransferases in Escherichia coli.

(Christensen DG, Meyer JG, Baumgartner JT, D'Souza AK, Nelson WC, Payne SH, Kuhn ML, Schilling B, Wolfe AJ.) mBio. 2019 04 09;10(2) PMID: 30967468 PMCID: PMC6456757 04/11/2019
Fast Proteome Identification and Quantification from Data-Dependent Acquisition-Tandem Mass Spectrometry (DDA MS/MS) Using Free Software Tools.

(Meyer JG.) Methods Protoc. 2019 Mar;2(1) PMID: 31008411 PMCID: PMC6469856 04/23/2019
High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets.

(Schilling B, Meyer JG, Wei L, Ott M, Verdin E.) Methods Mol Biol. 2019;1983:3-16 PMID: 31087289 PMCID: PMC6825508 05/16/2019

Biochemistry