Balaraman Kalyanaraman, PhD
Professor and Chair; Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research; Founder, Free Radical Research Center; Associate Director of Basic Research, Center for Disease Prevention Research
Visiting Fellow, Chemistry, Laboratory of Environmental Biophysics, National Institute of Environmental Sciences, Research Triangle Park, NC, 1978-1981
PhD, Chemistry, University of Alabama, Tuscaloosa, AL, 1978
MS, Chemistry, Indian Institute of Technology, Mumbai (formerly Bombay), India, 1972
BS, Chemistry, Loyola College, University of Madras, Chennai, India, 1970
In 1981, I joined the Biophysics section of the Department of Radiology at the Medical College of Wisconsin; in 1984, I became an assistant professor in the Department of Radiology; and in 1989, I became an associate professor in the Department of Biophysics. Currently, I am professor and chair of the Department of Biophysics. I have served as an associate editor for Free Radicals in Biology and Medicine,Free Radical Research, and Biochemical Journal.
My research interests are centered on the application of EPR in free radical biology and understanding the role of oxidants and antioxidants in signal transduction and apoptosis. My specific research areas are outlined below.
- Chemistry and Biophysics
- Detection of reactive oxygen and nitrogen species by EPR spin-trapping, fluorescence, optical stopped-flow, and HPLC techniques
- Syntheses of mitochondrially targeted spin traps, spin labels, and ROS-specific fluorescence probes
- EPR studies of mitochondria
- Mechanism of Signal Transduction/Cell Signaling
- Mitochondrial STAT3 and redox signaling
- Oxidant-induced iron signaling and apoptosis
- Chemotherapeutic drug toxicity and prevention (e.g., doxorubicin); mechanism of apoptosis in tumor cells and normal cells
- Mechanism of Disease
- Role of mitochondria-derived oxidants in chemically induced Parkinsonism (e.g., MPTP, rotenone) in cell culture and animal models; mechanism of protein aggregation, proteosomal dysfunction, and apoptotic neuronal cell death
- Targeting of metabolism, bioenergetics, and redox signaling in cancer
- Development of new mitochondria-targeted antitumor and antiproliferative drugs
My research projects include the following:
- Targeting Pancreatic Cancer Energy Metabolism, Tumor Growth, and Metastasis
The overall goal of this project is to develop new therapeutic approaches to inhibit PDAC malignancy.
- CYP2E1 Mediated Mitochondrial Injury and Cell Damage in Alcohol Liver Disease
A major objective here is to investigate the mechanisms of alcohol induced mitochondrial dysfunction and develop antioxidants and enzyme inhibitors to minimize alcohol induced liver damage.
Gang Cheng, PhD, Research Scientist II
Donna McAllister, Research Associate I
Laura McOlash, Research Technologist III
Monika Zielonka, Research Technologist III
(Chowdhury AR, Zielonka J, Kalyanaraman B, Hartley RC, Murphy MP, Avadhani NG.) Redox Biol. 2020 Jun 21;36:101606 PMID: 32604037 PMCID: PMC7327929 SCOPUS ID: 2-s2.0-85086919803 07/01/2020
Corrigendum to An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids [Free Radic. Biol. Med. 146 (2020) 150-159/FRBM_2019_405].
(Xu D, Huang CH, Qin L, Xie LN, Mao L, Shao J, Kalyanaraman B, Zhu BZ.) Free Radic Biol Med. 2020 May 20;152:869 PMID: 32253053 SCOPUS ID: 2-s2.0-85083056072 04/08/2020
(Shao J, Huang CH, Shao B, Qin L, Xu D, Li F, Qu N, Xie LN, Kalyanaraman B, Zhu BZ.) Environ Sci Technol. 2020 May 19;54(10):6244-6253 PMID: 32323976 SCOPUS ID: 2-s2.0-85084941154 04/24/2020
(Rios N, Radi R, Kalyanaraman B, Zielonka J.) J Biol Chem. 2020 May 08;295(19):6665-6676 PMID: 32217693 PMCID: PMC7212653 SCOPUS ID: 2-s2.0-85084721806 03/29/2020
(Zhang Q, Cheng G, Pan J, Zielonka J, Xiong D, Myers CR, Feng L, Shin SS, Kim YH, Bui D, Hu M, Bennett B, Schmainda K, Wang Y, Kalyanaraman B, You M.) Cell Commun Signal. 2020 Apr 07;18(1):58 PMID: 32264893 PMCID: PMC7140380 SCOPUS ID: 2-s2.0-85083071315 04/09/2020
(Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B.) Free Radic Biol Med. 2020 02 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019
(Kalyanaraman B.) Redox Biology. January 2020;29 SCOPUS ID: 2-s2.0-85075628069 01/01/2020
(Berliner L, Sarna T, Kalyanaraman B.) Cell Biochemistry and Biophysics. 2020 SCOPUS ID: 2-s2.0-85085293149 01/01/2020
An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids.
(Zhu BZ, Xu D, Qin L, Huang CH, Xie LN, Mao L, Shao J, Kalyanaraman B.) Free Radic Biol Med. 2020 01;146:150-159 PMID: 31302229 SCOPUS ID: 2-s2.0-85075485756 07/16/2019
Molecular mechanism for the activation of the anti-tuberculosis drug isoniazid by Mn(III): First detection and unequivocal identification of the critical N-centered isoniazidyl radical and its exact location.
(Qin L, Huang CH, Xu D, Xie LN, Shao J, Mao L, Kalyanaraman B, Zhu BZ.) Free Radic Biol Med. 2019 11 01;143:232-239 PMID: 31319159 SCOPUS ID: 2-s2.0-85070677474 07/19/2019
(Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A.) Breast Cancer Res. 2019 06 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019