Research Lab Bench

Biophysics Researcher Publishes Article Proposing a Mechanistic Link Between Parkinson’s Disease and Cancer

The connection between Parkinson’s disease (PD) and cancer may appear far-fetched; however, a recent review article by Balaraman Kalyanaraman, PhD, chair and professor of biophysics and the Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research, discusses a compelling rationale linking the two diseases from a mechanistic standpoint.

Dr. Kalyanaraman’s review article, titled Teaching the basics of repurposing mitochondria-targeted drugs: From Parkinson's disease to cancer and back to Parkinson's disease, which was published in Redox Biology, indicates that PD and cancer share overlapping genes, which implies that the two disease might share a common pathogenic mechanism. The article proposes the possibility of repurposing mitochondria-targeted drugs that are modifications of natural compounds and FDA-approved drugs for treating PD and cancer.