Research Lab Bench

Biophysics Researcher Publishes Review Article Discussing Possible Mechanisms for Enhanced Vulnerability of African Americans to SARS-CoV-2

COVID-19 severity is magnified in people with underlying medical conditions, and it disproportionately affects African Americans. A recent review article by Balaraman Kalyanaraman, PhD, chair and professor of biophysics and the Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research, discusses the hypothetical mechanisms for enhanced vulnerability of African Americans to SARS-CoV-2 infection, COVID-19 severity, and increased deaths.

Dr. Kalyanaraman’s review article, titled “Do free radical NETwork and oxidative stress disparities in African Americans enhance their vulnerability to SARS-CoV-2 infection and COVID-19 severity?” and published in Redox Biology, focuses on disparities in free radical neutrophil extracellular trap (NET) and oxidative stress in African Americans with autoimmune disorders, hypertension, obesity, and related disorders. The article hypothesizes that decreasing inflammatory & immune-system-related markers through supplementation with nutrients and other FDA-approved antioxidants and vitamins might mitigate the severity and mortality of SARS-CoV-2. This hypothesis needs to be tested using well-designed clinical trials.

This article can be viewed online at Redox Biology.