Prostate Cancer Center of Excellence Leadership
Marja Nevalainen, MD, PhD
Director, Prostate Cancer Center of Excellence
Professor, Eminent Scholar, Department of Pathology and Pharmacology & Toxicology; Assistant Dean of Research, Medical College of Wisconsin; Associate Director (Education), Medical College of Wisconsin Cancer Center
William Hall, MD
Clinical Co-Director, Prostate Cancer Center of Excellence
Prostate Cancer Center of Excellence Faculty
Associate Professor, Division of Epidemiology; Director, PhD Program in Public & Community Health; Co-Director, Global Health Pathway; Co-Director, GEO Shared Resource; Adjunct Associate Professor, Geography, UW-Milwaukee
Associate Investigator, Versiti Blood Research Institute; Associate Professor, Microbiology & Immunology
Jennifer Doll, PhD
Associate Professor, UW-Milwaukee
Associate Professor; Director, Quantitative Imaging Laboratory, Medical College of Wisconsin; Section of Imaging Research, Division of Imaging Sciences
Vice Chair, Professor
Professor and Gardetto Chair for Immunology and Immunotherapy; Professor, Medicine (Hematology and Oncology) and Microbiology & Immunology; Senior Investigator, Versiti Blood Research Institute
Professor; Associate Director Prevention & Control, Cancer Center
Senior Investigator, Versiti Blood Research Institute; Assistant Professor
Liang Wang, MD, PhD
Professor, Moffitt Cancer Center
Dr. Nevalainen is an internationally recognized leader in the field of cytokine and steroid hormone signaling in prostate cancer. The focus of her laboratory is on translational prostate cancer research to develop and improve diagnostics and therapy for prostate cancer. Dr. Nevalainen holds the title of Eminent Scholar at MCW. She is also Director of Prostate Cancer Center of Excellence at MCW Cancer Center, which is a multi-disciplinary hub for prostate cancer research with an international collaborative network. Dr. Nevalainen serves as Assistant Dean for Research at MCW, and Associate Director of Education for the MCW Cancer Center. Her primary appointment is in the Department of Pathology, and a secondary appointment in the Department of Pharmacology and Toxicology. Dr. Nevalainen has extensive experience in collaborative research, mentoring and leadership from her previous roles at Sidney Kimmel Cancer Center at Thomas Jefferson University as Associate Director of Education and Vice Chair of Education in the Department of Cancer Biology.
Dr. Karan’s research focuses on cancer immunology and immunotherapy, and to understand the role of inflammation in the development and progression of prostate cancer. Overall emphasis of his research is based on harnessing the power of immune system to improve its preventive and therapeutic efficacy against cancer cells using antigen-specific immunotherapy, natural compounds, and chemotherapy drugs. His laboratory addresses the role of immune system in antitumor therapy, activation of antitumor responses and characterization of antitumor effector mechanisms specific to prostate cancer.
The External Advisory Board for the Prostate Cancer Center of Excellence provides strategic and scientific direction, identifies opportunities for cross-institutional collaboration, provides assessments and feedback, and helps review grant applications.
Howard Soule, PhD
Executive Vice President
Chief Science Officer
Prostate Cancer Foundation
Howard R. Soule, PhD, since 1997 and as Chief Science Officer, coordinates global academic, government and biopharmaceutical sector research activity and is responsible for the implementation of the Prostate Cancer Foundation global research strategies. He is also a member of the Department of Defense Prostate Cancer Research Program Integration Panel.
Dr. Soule has been with the Foundation for 20 years. Prior to joining PCF in 1997, Dr. Soule was a senior R&D executive for nine years at Corvas International, Inc., a public biotechnology company. He was responsible for the discovery and development of innovative products for the treatment of life-threatening cardiovascular diseases. Dr. Soule has considerable experience in medical diagnostic and device industries as well. Dr. Soule received a PhD from Baylor College of Medicine in Virology and Epidemiology and was a Post-Doctoral Fellow in Immunology and Vascular Biology at the Scripps Research Institute.
Gail Prins, PhD
Professor of Urology and Physiology
Director of University Andrology Laboratory
University of Illinois at Chicago College of Medicine
Gail S. Prins, PhD, is the Michael Reese Professor of Urology in the Departments of Urology, Pathology and Physiology, University of Illinois at Chicago. She is the Director of the University Andrology Laboratories and co-Director of the NIEHS-funded P30 Chicago Center on Health and Environment. She is Past-President of Society for Basic Urologic Research (SBUR) and the American Society of Andrology (ASA).
Dr. Prins’ basic research program focuses on prostate gland development, prostate stem and progenitor cells, steroid receptors, hormonal carcinogenesis, BPH and endocrine disrupting chemicals (EDCs). She has published 180 manuscripts and 22 book chapters on her research which has been NIH funded for > 30 years. Dr. Prins received the 2009 Excellence in Urologic Research Award from the SBUR/SWIU, the 2011 UIC Researcher of the Year Award and the 2014 Distinguished Andrologist Award from the ASA. She has served on the DoD Integration Panel for the Prostate Cancer Research Program, and as member of multiple NIH Study Sections. She currently serves as Associate Editor of Environmental Health Perspectives and Journal of Clinical & Experimental Urology and as Editorial Board member of multiple scientific journals.
Angelo DeMarzo, MD, PhD
Professor of Pathology
Associate Director of Cancer Research Pathology
Johns Hopkins University School of Medicine
Dr. De Marzo has published more than 320 papers, reviews and book chapters, and he and colleagues described a potential new prostate cancer precursor/risk factor lesion for prostate cancer, proliferative inflammatory atrophy. His laboratory continues to study the role of inflammation in prostate carcinogenesis as well as the role of the MYC oncogene and the PTEN tumor suppressor in prostate cancer early disease development and progression. Along with colleagues, his lab is also heavily engaged in genomic studies of early prostate cancer and precursor lesions.
In addition, his lab also has a number of ongoing translational research efforts focused largely on using immunohistochemistry against PTEN and other biomarkers, where such markers might aid in diagnosis, prognosis, treatment stratification and disease resistance monitoring. Recently, his lab has also been performing extensive studies using multiplex immunofluorescence staining for inflammatory and other cell types, in situ hybridization for a number of different nucleic acid targets, as well as biospecimen science investigations related to optimizing methods of tissue handling for molecular studies.
Member of the Board of Directors
Wisconsin Breast Cancer Showhouse (WBCS)
Chair, WBCS Scientific Review Committee
Jan's focus as a volunteer and donor has always been on research and education, supporting avenues for advancement in these broad areas. She became involved with WBCS in 1998 when it was a fledgling nonprofit. Jan was honored to work closely with founder Nance Kinney and the early supporters and volunteers to facilitate basic breast cancer and prostate cancer research at MCW. WBCS is now a major supporter of the Prostate Cancer Center of Excellence at the MCW Cancer Center.
From the beginning WBCS has defined success by the partnerships and collaborations created among donors and scientists, and MCW and WBCS leadership, who together invest in promising research at an early stage. This success has been leveraged to grow and develop this small but mighty nonprofit into a force to advance discoveries and inspire all involved to make a difference for prostate cancer patients, families and the entire community.
All of Us Research Program
Do you want to change the future of health? The Froedtert & the Medical College of Wisconsin health network is part of the National Institutes of Health All of Us Research Program. It has a simple mission — speed up health research breakthroughs. To do this, All of Us is asking one million people to share their health information. Learn how you can help make a difference by joining the All of Us Research Program.
SELECTED PUBLICATIONSView additional prostate cancer research publications from 2014-2019.
Molecular Cancer Therapeutics, 2019
PC-COE Authors: Marja Nevalainen (Last/Corresponding Author), Deepak Kilari, William See, Kenneth Jacobsohn, Kenneth Iczkowski, Anjishnu Banerjee
Enzalutamide-induced Feed-Forward Signaling Loop Promotes Therapy-resistant Prostate Cancer Growth Providing an Exploitable Molecular Q2 Target for Jak2 Inhibitors
JAMA Oncology, 2019
PC-COE Author: William Hall
Quality of Life in Patients With Low-Risk Prostate Cancer Treated With Hypofractionated vs Conventional Radiotherapy: A Phase 3 Randomized Clinical Trial.
Lancet Oncology, 2018
PC-COE Author: Elizabeth Gore
Sequence of hormonal therapy and radiotherapy field size in unfavorable, localized prostate cancer (NRG/RTOG 9413): long-term results of a randomized, phase 3 trial.
Clinical Cancer Research, 2018
PC-COE Authors: Marja Nevalainen (Last Author), Carmen Bergom, William See
STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair.
- Dev Karan, PhD, NCI R01, Modulation of Host Intrinsic Immunity to Reduce Prostate Cancer Disparity
- Melinda Stolley, PhD, NCI R01, Men Moving Forward: A Lifestyle Intervention for African American Prostate Cancer Survivors
Pilot Grant Awardees:
- Peter LaViolette: Histological Validation of MRI of the Prostate
- Depak Kilari: Utility of Exosomal RNAs to Predict Responses to Androgen Deprivation Therapy in Prostate Cancer Patients
- H. Jeong: The Role of TPL2 Activation in Androgen-Depletion Independent (ADI) Prostate Cancer Growth
- William Hall: The Correlation of C-Reactive Protein with Biochemical Failure and Cancer Specific Outcomes following Radiation Therapy for Adenocarcinoma of the Prostate
- A. Banerjee: Bayesian Ensemble Prediction for Identifying and Classifying Heterogeneity of Cell Types in Prostate Cancer
- William Hall: The Correlation of C-Reactive Protein with Biochemical Failure and Cancer Specific Outcomes Following Radiation Therapy for Adenocarcinoma of the Prostate (Supplement)
- Marja Nevalainen: Stat5 and Anti-Androgen-Induced Metastatic Phenotype of Prostate Cancer
Memory T cell Biology
During an acute viral or bacterial infection, naïve T cells can differentiate into multiple types of effector and memory T cells that help to mediate pathogen clearance and provide long-term protective immunity. The main goal of our research in the lab is to elucidate how TCR and cytokine signaling and their downstream transcriptional programs regulate pathogen-specific T cells to proliferate, differentiate into either short-lived effector cells or long-lived memory cells.
Activated T cells receive and integrate a myriad of signals from their microenvironment. These signals differ in type, quality, quantity and duration, and could have significant impact on T cell activation, differentiation and survival. One area of our research interest is to study how these different signals cooperate with each other to regulate T cell expansion and acquisition of their effector function, and concurrently differ in their activities to control the short- or long-term fate decision. We aim to further investigate where and when these signals are produced and emanated, which will help to better understand how the distinct cellular niches influence effector and memory T cell fate decision and functional maturation.
JAK-STAT pathways are the important mediators to transmit extracellular signals into transcriptional programs that ultimately regulate effector and memory T cell differentiation, survival and homeostasis. Our recent work has demonstrated that STAT4 and STAT3 largely promote distinct cell fate commitment, and terminal effector versus memory cells respectively. A major focus in the lab currently is to better define how these different STAT pathways act in a synergistic or divergent fashion to regulate both terminal cell-fate commitment and permit plasticity in effector and memory T cells.
Dr. Doll’s research group has focused on two tumor suppressor proteins, which have potent anti-angiogenic activity, pigment epithelium derived factor (PEDF) and thrombospondin-1 (TSP-1). Both TSP-1 and PEDF are expressed in the normal prostate but, in PCa patient tissues, expression is decreased or absent, thus suggesting a role in disease progression. Initial studies elucidated the roles of the proteins in prostate tumor angiogenesis; however, additional studies led to the observations that these proteins also function in regulating metabolic pathways, such as lipid and energy metabolism, particularly in an obese setting. With over 30% of U.S. adults considered to be obese, an obesity contributing the incidence and progression of many types of cancer, understanding how obesity and a high fat diet impact cancer metabolism and progression is essential. Her current studies are aimed to identify the specific molecular pathways through which an obese microenvironment alters cellular metabolism and specifically to elucidate the roles of PEDF and TSP-1 in these functions in prostate cancer. The ultimate goal of these studies is to identify druggable targets for obese prostate cancer patient therapy development.
I am a board certified radiation oncologist with a passion for research in prostate cancer and radiological sciences. I balance a busy clinical practice treating primarily prostate and GI malignancies with an active research career. Thus far, in the early portion of my career, I have devoted my efforts to understanding novel biomarkers of radiation therapy treatment response. In addition I have focused on the integration of advanced imaging modalities, including MRI, into radiation treatment planning. Moreover, I have published several peer-reviewed articles devoted to the optimal use of radiation therapy for prostate cancer. Such articles have specifically related to radiation therapy technological advances, MRI incorporation into radiation planning, and the optimal radiation therapy dosing strategy. My future research goals are focused on developing and improving our ability to identify novel metrics of response to radiation therapy using both serum biomarkers and imaging biomarkers. In addition, I hope to develop MRI strategies that would use novel and unique MRI sequences to enable precise delineation of the most malignant portions of a tumor. My aspiration is to work closely with collaborators to refine our ability to accurately identify malignant tissue and direct intensification of local radiation therapy.
My ongoing research in prostate cancer focuses on two main areas: 1. serum inflammatory cytokines and their association with response to radiation therapy and 2. advanced imaging modalities to guide treatment with highly precise radiation therapy. In this regard I have recently completed a validation study measuring the serum inflammatory cytokines in patients with high risk prostate cancer. In this study, we examined the influence of C-reactive protein (CRP) serum levels on treatment outcomes after radiation therapy using serum samples from a large phase III clinical trial that recently completed. In addition we examined an array of serum cytokines for their correlations with response to treatment with radiation therapy. We found that pre-treatment levels of IL-10 appear to correlate with response to treatment with radiation. In addition, we found that several pre-treatment serum cytokine levels appear to correlate with the development of toxicity. In addition to this translational work I also have a strong interest in MR guided radiation therapy, along with advance imaging techniques to improve prostate radiation therapy. In this regard I am conducting a prospective observational trial collecting MRI’s during a treatment course with radiation therapy. We have recently shown some changes in the rectal wall that occur during treatment with radiation when closely examined using MR guidance. If expanded to a larger cohort, these results could be used as potential novel metrics of toxicity monitoring in men with prostate cancer being treated with curative radiation therapy.
Dr. Iczkowski was trained in anatomic pathology and completed fellowships in surgical and cytologic pathology at University of Kansas followed by urologic (GU) pathology at Mayo Clinic Rochester (1998). In addition to being a surgical and urologic pathologist, he also ran an extramurally funded research laboratory from 2002-2010, focused on the role of CD44 and cell adhesion in prostate cancer invasion and growth.
Dr. Iczkowski’s current research effort in prostate cancer is focused on inflammatory biomarkers NF-kappa B and GDF-15. These molecules in the prostate are involved in carcinogenesis and tumor development. They also appear to be deferentially expressed between African-American men’s and Caucasian men’s prostates.
Dr. Iczkowski has also published extensively on the various growth patterns of prostate cancer. Dr. Iczkowski was the first in his field to publish the finding that cribriform growth pattern of Gleason grade 4 prostatic adenocarcinoma has a particularly worse outcome than the identically-graded Gleason grade for non-cribriform prostatic adenocarcinoma. He has published work including PTEN and p27 expression as they relate to patterns of prostate cancer growth.
For the past several years, Dr. Iczkowski has collaborated with Dr. Peter LaViolette (Radiology) on a project to perform correlation of prostate cancer grades and patterns of growth with findings on magnetic resonance imaging. These studies included machine-learning of prostate cancer grading based on expert digital 'annotation' of prostate cancer foci in scanned whole-mount slides. This collaboration has resulted in several publications.
Finally, Dr. Iczkowski collaborates with Dr. Marja Nevalainen’s group (Pathology) in harvesting prostate cancer from prostatectomy specimens. The few-millimeter piece of tissue is examined by frozen section to determine the presence of cancer, so that the tissue can be used for establishing and running 3D tumor explant cultures and xenografts of patient-derived prostate cancer. He also works with Dr. Nevalainen on studying cancers with predominant neuroendocrine/ small cell differentiation and their expression of STAT5 and related markers of prognosis.
Kenneth Jacobsohn, MD, is fellowship trained in minimally-invasive urologic oncology and board-certified in urology. He is the director of minimally invasive urologic surgery at MCW and a professor of urology. Dr. Jacobsohn specializes in robotic surgery for malignant and benign urologic diseases. He has pioneered many technical advances and firsts in robotic urologic surgery and is a dedicated clinician who focuses intensely on balancing his patients oncologic and quality of life outcomes. He has been instrumental in the development and use of MRI for prostate cancer imaging at Froedtert & MCW. Dr. Jacobsohn has emerging interests in prostate cancer prevention and the role of nutrition in prostate cancer development on and progression.
Dr. Jacobsohn collaborates with Dr. Nevalainen for optimization of the 3D tumor explant culture system of patient-derived prostate cancers. He partners with Dr. LaViolette on his innovative MRI-based prostate cancer imaging techniques. Other current efforts include development of the Functional Anatomy Sparing Technique for Prostatectomy (FAST-P), and retzius-sparing prostatectomy.
Colleen A. F. Lawton, MD is an internationally recognized Genitourinary Radiation Oncologist who has gained this recognition through her research in prostate cancer. She has worked for several decades focusing on clinical research in all aspects of prostate cancer from localized disease to locally advanced. In addition, Dr. Lawton has served as the president of the American Society of Radiation Oncology (ASTRO) where prior to becoming president, she served on the board working on educational programs in prostate cancer. She has also served as the program director for the Medical College of Wisconsin Radiation Oncology Residency Program for approximately 25 years and as such received the Association of Residents of Radiation Oncology Educator of the Year Award. Dr. Lawton is also a nationally recognized leader in total body irradiation for stem cell transplant. She has given national educational courses on the topic and was awarded an American Cancer Society Career Development Award for research in this arena. Dr. Lawton currently serves as the Vice Chair of the Medical College of Wisconsin Department of Radiation Oncology.
Dr. Lawton’s research in total body irradiation for stem cell transplant was the first to show a renal toxicity issue that could be addressed via partial shielding of the kidneys and subsequently the same issue with the lungs and liver. She began her focus on prostate cancer clinical research with her involvement in the Radiation Therapy Oncology Group (RTOG now NRG) national cooperative clinical trial group in the early 1990’s with two trials. The first RTOG 94-13 established that there was a clear role for radiation to the pelvic lymph nodes in addition to the prostate for locally advanced prostate cancer patients. The next trial RTOG 98-05 was the first multi institutional trial demonstrating the ability to successfully treat localized prostate cancer with LDR (low dose rate) I131 seeds in a cooperative group setting. This trial stemmed from a similar successful MCW single institution trial. Her next trial RTOG 00-19 proved that for intermediate risk prostate cancer patients, LDR brachytherapy in addition to external beam radiation added toxicity but no clear improvement in prostate cancer control compared to LDR brachytherapy alone.
Her most recent completed RTOG/NRG trial was 09-38 which has shown the ability to treat localized prostate cancer with hypofractionation. This trial was designed to show whether prostate cancer treated in 12 fractions over 2.5 weeks verses 5 fractions over 2.5 weeks was equal in terms of cancer control and toxicity. Early results suggest equivalency in terms of both.
Finally she is continuing her work within the NRG cooperative group with the development of trial NRG-GU1817 which will address locally advanced/lymph node positive prostate cancer patients with local regional radiation in addition to newer systemic agents looking at improving the outcomes for this group of patients thought to be incurable.
Marja Nevalainen, MD, PhD is an internationally recognized leader in the field of cytokine and steroid hormone signaling in prostate cancer. The focus of her laboratory is on translational prostate cancer research to develop and improve diagnostics and therapy for prostate cancer. Dr. Nevalainen holds the title of Eminent Scholar at MCW. She is also Director of Prostate Cancer Center of Excellence at MCW Cancer Center, which is a multi-disciplinary hub for prostate cancer research with an international collaborative network. Dr. Nevalainen serves as Assistant Dean for Research at MCW, and Associate Director of Education for the MCW Cancer Center. Her primary appointment is in the Department of Pathology, and a secondary appointment in the Department of Pharmacology and Toxicology. Dr. Nevalainen has extensive experience in collaborative research, mentoring and leadership from her previous roles at Sidney Kimmel Cancer Center at Thomas Jefferson University as Associate Director of Education and Vice Chair of Education in the Department of Cancer Biology.
- Jak-Stat signaling
- Prostate cancer progression
- Therapy development
- Companion diagnostics
- Predictive Factors
- DNA repair
- Radiation therapy
- In vitro and in vivo models
- 3D tumor explant culture
- Epithelial-mesenchymal transition
- Cancer stem-like cell properties
- Metastases models
- Small molecule therapeutics
Dr. Nevalainen’s group provided the initial proof-of-concept that Jak2-Stat5-axis is a therapeutic target in prostate cancer. Dr. Nevalainen’s group made the seminal finding of Stat5 as a critical factor for prostate cancer cell viability and growth in vitro, in vivo in xenograft tumor models and ex vivo in patient-derived clinical prostate cancers. Her group further established the concepts of: 1) Stat5 as a critical inducer of castrate-resistant prostate cancer growth, 2) Stat5 as a predictive factor of early prostate cancer recurrence and disease-specific death after radical prostatectomy, 3) Stat5 as a inducer of prostate cancer stem cell properties, epithelial-to-mesenchymal transition and metastatic disease, 4) Stat5 as a regulator of homologous recombination DNA repair and radiation response of prostate cancer. In recent work, using medicinal chemistry Dr. Nevalainen and collaborators have identified a family of novel small molecule Stat5 inhibitors with high efficacy in both PC and Bcr-Abl-driven leukemias. Dr. Nevalainen’s research accomplishments include development of an androgen-dependent human PC cell line which mimics the course of human disease when grown as xenograft tumors in nude mice.
Specifically, the tumors response to androgen deprivation by regression but regrow eventually back as castrate-resistant tumors. Dr. Nevalainen is further recognized in her field for early development of a long-term 3D tumor explant culture system for normal and malignant prostate tissue for efficacy testing of experimental biologics and small-molecules ex vivo in clinical PCs from patients and as an experimental model system for identification of growth factor and drug modulated signaling proteins in prostate tissue.Recent work from her laboratory demonstrated a novel role for Stat5 as regulator of radiation response of prostate cancer through control of Rad51 levels and homologous recombination DNA repair. Current work focuses on Jak-Stat signaling in anti-androgen resistance of prostate cancer, Stat5 regulation of BRCAness of prostate cancer, optimization of the lead compound Stat5 inhibitor and interaction of Jak2-Stat5 signaling with androgen receptor signaling network in prostate cancer.
Dr. Park’s basic science research is supported by the NIH-National Cancer Institute. He also participates in clinical cancer research by serving the NCI-MATCH Precision Medicine Cancer Trial as the Translational Chair of the Dabrafenib & Trametinib combination therapy arm, which targets BRAF-driven cancer. He was an American Cancer Society Research Scholar and a member of the ACS MEN2 Thyroid Cancer Consortium.
Dr. Park’s areas of interest in prostate cancer include the role of MAPK pathways in PCa. Previously, Dr. Park’s lab demonstrated that ERK1/2 has a role in regulating androgen receptor and neuroendocrine differentiation of PCa and that a cross-talk is established between AKT and B-Raf under androgen-deprived conditions.
Hong SK, Kim JH, Lin MF, Park JI (2011) The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor down regulation in prostate cancer cells. Exp Cell Res 317: 2671-82
Hong SK, Jeong JH, Chan AM, Park JI (2013) AKT up regulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion. Exp Cell Res 319: 1732-4
Dr. Sarah Patch received her BS in Mathematics & Computational Sciences from Stanford University in 1989 and her PhD in Applied Math from UC Berkeley in 1994. She then obtained a National Science Foundation Postdoctoral Fellowship in Mathematical Sciences and worked at the Institute for Mathematics and its Applications from 1994 to 1995. In 1995, she was awarded a Humboldt Postdoctoral Fellowship to work at the University of Muenster, Germany. The following year Patch went back to Stanford University. From 1997 to 1999 Patch held a position GE’s Corporate Research and Development Center; in 2005 she joined GE Medical Systems’ Applied Science Lab in Milwaukee. Since 2005, she has been working at University of Wisconsin-Milwaukee. Professor Patch is inventor on more than 10 patents, as well as author on numerous publications. Her work has been supported by NIH, NSF, and DARPA.
Thermoacoustic Range Verification During Particle Therapy
A controversial application of proton therapy is prostate cancer treatment. To spare radiosensitive rectal tissue the standard prostate cancer protocol treats only with horizontal beams, which travel through thick bony structures before reaching the prostate. Bone degrades the proton beam’s energy spectrum, minimizing the advantage of proton therapy over intensity modulated x-ray radiation therapy. Horizontal-only delivery maximizes proton path length through hip and thighbones. Accurate range verification could enable delivery using oblique beams that avoid large bones and maintain a sharp Bragg peak, taking full advantage of the potential of particle therapy. Therefore, we performed a Monte Carlo simulation study and developed a two-step method for accurately estimating the Bragg peak location from thermoacoustic emissions measured by receivers that could be embedded onto the form factor of a transrectal ultrasound imaging array (Fig. 1,MedPhys45(2):783-793).
Fig. 1. Monte Carlo simulations of oblique beam and range estimates from SNR=0 dB signals overlaid on planning CT.“+” indicate locations of low frequency receive elements projected orthogonally onto each CT plane. Axial, sagittal, and coronal planes through true Bragg peak location in (a) through (c), respectively. White line in (a) and (d) indicates beamline. Magenta dot is true Bragg peak location. Yellow triangle and circle indicate orthogonal projections of beamformed and final estimates. (d) Zoomed image of axial plane near Bragg peak. CT display window is [-200, +200] HU.
Fig. 2. Bragg peak locations for “control” beams and “measured” beam are plotted with magenta squares and dot, respectively. Dotted yellow lines connect the transducer locations to the beamformed estimate (yellow triangle). A dashed line connects the beamformed estimate to the nearest control point, and a solid yellow line connects the control point to the final estimate (yellow circle).
Demin Wang, PhD is a nationally and internationally recognized leader in the field of hematopoiesis and immunology. His scientific interests focus on studying the signal regulation of hematopoietic stem cells and B lymphocytes. Dr. Wang’s research program aims to understand the molecular pathogenesis of various hematological and immunological diseases and cancers, and to suggest new approaches to prevention and treatment of these disorders. He is the recipient of American Cancer Society Research Award and the recipient of Leukemia and Lymphoma Society Scholar Award, USA. Presently, and holds the John B and Judith A Gardetto Endowed Chair for Cancer Research. Dr. Wang’s primary appointment is in the Versiti Blood Research Institute and a secondary appointment in the Department of Microbiology & Immunology, Medical College of Wisconsin. He is also an editorial board member of the peer-reviewed medical journal Blood.
Hematopoietic stem cells (HSCs) give rise to all blood cells, including erythroid, myeloid and lymphoid lineages. The self-renewal and hematopoietic differentiation of HSCs are strictly controlled by both extrinsic and intrinsic signals. B cells, a subtype of lymphoid cells,are critical to the immune defense, and their development and function are also highly regulated by signals derived from a variety of cell surface receptors. Abnormal signals from the receptors often lead to multiple diseases, including malignancies, and immunodeficiency and autoimmune diseases. Dr. Wang’s research focuses on identifying and functionally characterizing signaling pathways that control B cell development from HSCs. His research employs multiple cutting-edge approaches, including targeted gene disruption,transgenic,bone marrow transplantation and high-throughput DNA/RNA sequencing technologies. Dr. Wang has identified a number of important molecular components, including PLC1, PLC2, Bcl10, TAK1, Stat5, et al,of the signaling pathways that play critical roles in regulating hematopoiesis/lymphopoiesis. His research findings have significantly advanced our understanding of the regulation of hematopoiesis and lymphopoiesis.
Cytokine receptors regulate a variety of cellular responses, including cell growth, survival, differentiation, and function. Engagement of cytokine receptors induces the activation of the JAK family of protein tyrosine kinases. In turn, Jaks activate components of diverse signal transduction pathways, including members of the Signal Transducers and Activators of Transcription (Stat). Dysregulation of JAK/Stat pathway is implicated in the pathogenesis of numerous diseases. Stat5is activated by the prolactin receptor and is critical for prostate cancer cell viability, growth, metastasis and dissemination. Constitutively activated Stat5is associated with high grade prostate cancers, and prostate cancer recurrence and metastasis. Inhibition of stat5 activity induces rapid prostate cancer cell death and prevents prostate tumor growth in mice. One of Dr. Wang’s current research projects studies the regulation and function of Stat5 protein. He has identified a naturally occurring C-terminal truncated Stat5 that lacks the transcription activation domain and thus acts as a dominant negative form. His recent work discovered a novel mechanism underlying the down regulation of Stat5 in tumor cells. Dr. Wang’s laboratory is exploring this novel down regulation of Stat5 signaling pathway for inhibiting prostate cancer cell proliferation and survival, and thus preventing prostate cancer progression.
Clinical Cancer Researchers and Clinicians
Patient and Family Resources
Information About Prostate Cancer from the National Cancer Institute
Information About Prostate Cancer from the American Cancer Society
American Cancer Society Recommendations for Prostate Cancer Screening/Early Detection
Prostate Cancer Patient Guide from the Prostate Cancer Foundation
Us Too - Prostate Cancer Organization (In-Person and Phone Support Groups, Caregiver Support Groups)
Men Moving Forward Lifestyle Program for African American Prostate Cancer Survivors at the MCW Cancer Center: Contact Jonette (Tina) Johnson at email@example.com.