The Prevent Anal Cancer (PAC) Study

PAC Study Photo Men of Color

About the Study 

There is a much greater risk for anal cancer among gay and bisexual men, especially gay and bisexual men who are HIV-positive. But we don’t know the best way for people to get screened.

The PAC Study aims to change that. This study will find ways to detect anal cancer earlier, when it’s much easier to treat.

We will enroll gay and bisexual men and transgender persons in Chicago, Houston, and Milwaukee into a study with two or three clinic visits over one-year. Participants will receive up to $130 to help us learn better ways to find anal cancer.

This study is funded by the National Cancer Institute at the National Institutes of Health. It is being led by researchers at the Medical College of Wisconsin in partnership with community-based organizations, community clinics, and other universities.

If you would like more information about the study, please contact us.

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Study Consent Forms

We invite you to assess and read the study consent form before a virtual consenting appointment.

Learn More

Click on each + to take the eligibility survey, learn more about the study team, and find out more about anal cancer and screening.
Are You Eligible to Participate?
See if you are eligible to participate in the PAC study.


About Anal Cancer: Information, Data & Resources

If you don't want to participate in the study, but would like to learn more about anal cancer, you can use the links below to access resources on anal cancer.

The Bottom Line organization website.

UCSF Anal Cancer Information website.

National Cancer Institute anal cancer website.

Meet the Study Team and Our Partners

Meet the PAC study team at the Medical College of Wisconsin:

Alan Nyitray, PhD, Principal Investigator and Professor, MCW Cancer Center and Center for AIDS Intervention Research

Alan Nyitray is an Associate Professor of Epidemiology at the Medical College of Wisconsin in Milwaukee. His research has focused on the natural history of anal HPV infection and, most recently, anal cancer screening. The anal HPV epidemiology research has included studies with gay, bisexual, and other men who have sex with men, heterosexual couples, and heterosexual men. His current research assesses protocols for anal precancer and cancer screening. He has published more the 50 peer-reviewed papers on these topics and is funded by the National Cancer Institute. Prior to his HPV research, Nyitray delivered HIV prevention in a service capacity for 15 years.

Christopher Ajala, MD, MPH, Clinical Research Coordinator

Christopher is a clinical researcher who supports Dr. Nyitray, coordinating the PAC anal cancer screening studies at MCW. Christopher has content expertise in scientific principles and research methodology. He has a master’s degree in Public Health Administration and Policy from the University of Minnesota School of Public Health, Twin Cities. In addition to his public health experience, he is a trained physician from Nigeria.

Bridgett Brzezinski, MA (Master of Arts in Health Communication), Community Research Assistant

Bridgett is a Community Research Assistant III with Dr. Alan Nyitray. She supports the PAC studies looking at anal cancer prevention, working at the MCW Cancer Center, the Center for AIDS Intervention Research, and with five Milwaukee clinics, supporting participants and the community. Bridgett’s undergraduate background is in Corporate Communication and Women’s Studies. She also holds a master’s degree in Health Communication with a research focus on sexual health and physician-patient communication.

The PAC Study in the News: Publications, Presentations & Other Media

Research publications, presentations, and other media.

Nyitray Siker BannerPAC Study Principal Investigator Dr. Alan Nyitray featured for his work with the LGBTQ+ community with colleague Dr. Malika Siker.  





CAjala Poster PresentationPAC Study Coordinator Christopher Ajala, MD, MPH, presents a scientific poster on the PAC study methodology titled, "Protocol of the Prevent Anal Cancer Study of Self-Swabbing and Novel Biomarkers," at the MCW Cancer Center 2019 Scientific Retreat. 




A Niytray Presentation Photo

PAC Study Principal Investigator Dr. Alan Nyitray presents his talk titled, "Novel Opportunities for Anal Cancer Screening Among Men" at the MCW Cancer Center 2019 Scientific Retreat. 

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Contact Us & Get Involved

General Contact Information

PAC Study, Medical College of Wisconsin Cancer Center:

Or you can contact the study team at the Medical College of Wisconsin:

Study Coordinator: Christopher Ajala, MD, MPH, or (414) 882-0085

Study Coordinator: Sandile Nukuna, BA, or (414) 882-0036

Research Assistant: Bridgett Brzezinski, MA,, (414) 882-0131

Principal Investigator: Alan Nyitray, PhD, or (414) 805-3312