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Cancer Center

Biomedical Imaging Shared Resource (BISR)

The Biomedical Imaging Shared Resource (BISR) advances Medical College of Wisconsin Cancer Center research by providing expertise and state-of-the-art technology. Specifically, the shared resource features imaging technologies and methods that assist investigators as they assess cancer growth, metabolism and response to therapy, greatly increasing the translational potential of cancer center research.

Contact

Amit Joshi, PhD | Co-Director | (414) 955-7588
Peter LaViolette, PhD | Co-Director | (414) 955-7490

Biomedical Imaging Shared Resource (BISR)Location and Hours of Operation

BISR services are available 8:00 am-5:00 pm Monday through Friday. Depending on staff availability and user training/experience, off-hour access to scanners is available in support of experiments requiring unique schedules. Specific locations of key equipment are listed below.

Services

The BISR provides the following services:

  • Data acquisition (e.g., novel pulse sequence development/verification, phantom construction, routine acquisition)
  • Postprocessing, data analysis, archiving and mining
  • Protocol design
  • Modality selection, as per imaging goals
  • Assistance in defining imaging goals (e.g., biomarker validation, drug response, pharmacokinetics, etc.)

In addition, the directors offer mentoring and educational opportunities in the way of seminars, retreats and formal machine training sessions. These services provide investigators with the opportunity to leverage their imaging studies as they seek extramural funding.

Key Equipment

The BISR has small-animal and human imaging systems dedicated for research purposes.

GE Healthcare Discovery MR950 7T Human MRI| Located in the Center for Imaging Research (CIR)
The GE 7T MR950 system is a 90-cm bore, investigational human research MRI system.

GE Healthcare Discovery MR750 3T MR System| Located in the Froedtert & Medical College Pavilion
The GE 3T MR750 system is a 60-cm bore, clinically certified MRI system that is dedicated to research.

Bruker BioSpec 94/30 USR 9.4T Preclinical MRI System| Located in the CIR
The Bruker BioSpec in vivo spectroscopy imaging system has an actively shielded 9.4T magnet with a 31-cm warm bore.

Triumph Micro SPECT-CT | Located in the CIR
Triumph micro SPECT/CT (X-SPECT) offers superior imaging capabilities for use in small-animal in vivo studies.

PerkinElmer IVIS-100 Bioluminescence Imaging System | Located in the Biomedical Resource Center
The IVIS system allows in vivo bioluminescence imaging in mice and rats with an enzymatic bioluminescence expressing tag (e.g., luciferase).

NIR and Short-Wave Infrared Imaging (SWIR) Located in the Translational and Biomedical Research Center
The BISR has access to specialized sensitive intensified CCD (ICCD) camera-based instrumentation sensitive from visible (400 nm) to short-wave infrared (IR) (1900 nm) wavelengths.

Philips/Elekta Combined MR-Linac (Linear Accelerator) | Will be located in the Department of Radiation Oncology
This machine can simultaneously irradiate tumors and collect MR images for optimized targeting and treatment response monitoring.

For more information about this equipment, please see the Center for Imaging Research website.