David Gutterman Lab
David Gutterman, MD
Northwestern Mutual Professor, Department of Medicine
Dr. Gutterman is actively involved in clinical practice, supervises a NIH funded research laboratory and provides senior administrative oversight of research administration at the Medical College of Wisconsin. He has served in a leadership role in a variety of national and international cardiovascular scientific organizations.
Research Technologist II
Within Dr. Gutterman’s lab my primary role is to collect and analyze experimental data for multiple research projects and to provide support where needed to meet the goals of the laboratory faculty. I have background in cell biology and regenerative medicine and an interest in genetics and physiology.
Andrew D. Kadlec, PhD
MD Student; Medical Scientist Training Program (MSTP)
Andy Kadlec is an MD/PhD student in the Medical Scientist Training Program (MSTP) at MCW. His research interests include studying vascular biology from a largely translational approach. In collaboration with Dr. David Gutterman, Dr. Beyer serves as a key mentor and collaborator for his research efforts. Together, they aim to uncover the regulatory role played by the mitochondria within the murine and human vascular endothelium. Andy’s project investigates the interaction between PGC-1alpha, a key player in mitochondrial biogenesis, and telomerase within the context of atherosclerotic disease. They hope to identify novel vascular targets to combat atherosclerosis.
As a graduate student in Dr. Gutterman’s lab, I am interested in endothelium-independent vascular pathophysiology. Currently, my focus lays in the area of ion channel-mediated hyperpolarization and relaxation of vascular smooth muscle cells in the microcirculation which is critical in regulating myocardial perfusion. Using cannulated vessels in combination with electrophysiological and molecular techniques, I plan to examine the role coronary artery disease (CAD) has in modulating voltage-activated potassium channel-mediated hyperpolarization of vascular smooth muscle cells and dilation of resistant coronary arterioles.
- Jasmine Linn
- Victoria Nasci
(Durand MJ, Ait-Aissa K, Levchenko V, Staruschenko A, Gutterman DD, Beyer AM.) Cardiovasc Res. 2018 Nov 22.
(Chabowski DS, Kadlec AO, Ait-Aissa K, Hockenberry JC, Pearson PJ, Beyer AM, Gutterman DD.) Br J Pharmacol. 2018 Nov;175(22):4266-4280.
(Abraham WT, Kuck KH, Goldsmith RL, Lindenfeld J, Reddy VY, Carson PE, Mann DL, Saville B, Parise H, Chan R, Wiegn P, Hastings JL, Kaplan AJ, Edelmann F, Luthje L, Kahwash R, Tomassoni GF, Gutterman DD, Stagg A, Burkhoff D, Hasenfuß G.) JACC Heart Fail. 2018 Oct;6(10):874-883.
(Allaqaband H, Gutterman DD, Kadlec AO.) Physiology (Bethesda). 2018 09 01;33(5):338-347.
(Hyngstrom AS, Murphy SA, Nguyen J, Schmit BD, Negro F, Gutterman DD, Durand MJ.) J Appl Physiol (1985). 2018 May 01;124(5):1140-1147.
(Ait-Aissa K, Kadlec AO, Hockenberry J, Gutterman DD, Beyer AM.) Am J Physiol Heart Circ Physiol. 2018 05 01;314(5):H1053-H1060.
(Kadlec AO, Gutterman DD.) Am J Physiol Heart Circ Physiol. 2018 05 01;314(5):H892-H894.
(Kadlec AO, Barnes C, Durand MJ, Gutterman DD.) Am J Hypertens. 2018 Jan 12;31(2):240-246.
(Das EK, Lai PY, Robinson AT, Pleuss J, Ali MM, Haus JM, Gutterman DD, Phillips SA.) Front Physiol. 2018;9:183.
(Nishijima Y, Korishettar A, Chabowski DS, Cao S, Zheng X, Gutterman DD, Zhang DX.) Microcirculation. 2018 01;25(1).
PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure.
(Kadlec AO, Chabowski DS, Ait-Aissa K, Hockenberry JC, Otterson MF, Durand MJ, Freed JK, Beyer AM, Gutterman DD.) Hypertension. 2017 07;70(1):166-173.
(Freed JK, Gutterman DD.) J Cardiovasc Pharmacol. 2017 May;69(5):264-272.