David Gutterman Lab
David Gutterman, MD
Northwestern Mutual Professor, Department of Medicine
Dr. Gutterman is actively involved in clinical practice, supervises a NIH funded research laboratory and provides senior administrative oversight of research administration at the Medical College of Wisconsin. He has served in a leadership role in a variety of national and international cardiovascular scientific organizations.
Andrew D. Kadlec, PhD
MD Student; Medical Scientist Training Program (MSTP)
Andy Kadlec is an MD/PhD student in the Medical Scientist Training Program (MSTP) at MCW. His research interests include studying vascular biology from a largely translational approach. In collaboration with Dr. David Gutterman, Dr. Beyer serves as a key mentor and collaborator for his research efforts. Together, they aim to uncover the regulatory role played by the mitochondria within the murine and human vascular endothelium. Andy’s project investigates the interaction between PGC-1alpha, a key player in mitochondrial biogenesis, and telomerase within the context of atherosclerotic disease. They hope to identify novel vascular targets to combat atherosclerosis.
As a graduate student in Dr. Gutterman’s lab, I am interested in endothelium-independent vascular pathophysiology. Currently, my focus lays in the area of ion channel-mediated hyperpolarization and relaxation of vascular smooth muscle cells in the microcirculation which is critical in regulating myocardial perfusion. Using cannulated vessels in combination with electrophysiological and molecular techniques, I plan to examine the role coronary artery disease (CAD) has in modulating voltage-activated potassium channel-mediated hyperpolarization of vascular smooth muscle cells and dilation of resistant coronary arterioles.
Daniela Didier is a Lab Manager whose time is shared between Drs. David Gutterman, Andreas Beyer, Julie Freed, and David Zhang. In addition to administrative duties, Dani helps coordinate ongoing projects in the lab, tissue acquisition, and cell culture including in vitro model of angiogenesis.
- Joseph Hockenberry
- Jasmine Linn
- Victoria Nasci
(Grosman-Rimon L, Wright E, Freedman D, Kachel E, Hui S, Epstein I, Gutterman D, Eilat-Adar S.) Am J Physiol Heart Circ Physiol. 2019 09 01;317(3):H487-H495.
(Anker SD, Borggrefe M, Neuser H, Ohlow MA, Röger S, Goette A, Remppis BA, Kuck KH, Najarian KB, Gutterman DD, Rousso B, Burkhoff D, Hasenfuss G.) Eur J Heart Fail. 2019 Sep;21(9):1103-1113.
(Durand MJ, Ait-Aissa K, Levchenko V, Staruschenko A, Gutterman DD, Beyer AM.) Cardiovasc Res. 2019 Aug 01;115(10):1546-1556.
(Mahmoud AM, Hwang CL, Szczurek MR, Bian JT, Ranieri C, Gutterman DD, Phillips SA.) Nutrients. 2019 Jun 14;11(6).
(Ait-Aissa K, Blaszak SC, Beutner G, Tsaih SW, Morgan G, Santos JH, Flister MJ, Joyce DL, Camara AKS, Gutterman DD, Donato AJ, Porter GA Jr, Beyer AM.) Sci Rep. 2019 May 20;9(1):7623.
(Durand MJ, Boerger TF, Nguyen JN, Alqahtani SZ, Wright MT, Schmit BD, Gutterman DD, Hyngstrom AS.) J Appl Physiol (1985). 2019 Mar 01;126(3):755-763.
(Chabowski DS, Kadlec AO, Ait-Aissa K, Hockenberry JC, Pearson PJ, Beyer AM, Gutterman DD.) Br J Pharmacol. 2018 11;175(22):4266-4280.
(Abraham WT, Kuck KH, Goldsmith RL, Lindenfeld J, Reddy VY, Carson PE, Mann DL, Saville B, Parise H, Chan R, Wiegn P, Hastings JL, Kaplan AJ, Edelmann F, Luthje L, Kahwash R, Tomassoni GF, Gutterman DD, Stagg A, Burkhoff D, Hasenfuß G.) JACC Heart Fail. 2018 10;6(10):874-883.
(Allaqaband H, Gutterman DD, Kadlec AO.) Physiology (Bethesda). 2018 09 01;33(5):338-347.
(Hyngstrom AS, Murphy SA, Nguyen J, Schmit BD, Negro F, Gutterman DD, Durand MJ.) J Appl Physiol (1985). 2018 05 01;124(5):1140-1147.
(Ait-Aissa K, Kadlec AO, Hockenberry J, Gutterman DD, Beyer AM.) Am J Physiol Heart Circ Physiol. 2018 05 01;314(5):H1053-H1060.
(Das EK, Lai PY, Robinson AT, Pleuss J, Ali MM, Haus JM, Gutterman DD, Phillips SA.) Front Physiol. 2018;9:183.