David Gutterman Lab

David Gutterman

David Gutterman, MD
Principal Investigator
Northwestern Mutual Professor, Department of Medicine
dgutt@mcw.edu

Dr. Gutterman is actively involved in clinical practice, supervises a NIH funded research laboratory and provides senior administrative oversight of research administration at the Medical College of Wisconsin. He has served in a leadership role in a variety of national and international cardiovascular scientific organizations.

Andrew D. Kadlec, PhD
MD Student; Medical Scientist Training Program (MSTP)
akadlec@mcw.edu

Andy Kadlec is an MD/PhD student in the Medical Scientist Training Program (MSTP) at MCW. His research interests include studying vascular biology from a largely translational approach. In collaboration with Dr. David Gutterman, Dr. Beyer serves as a key mentor and collaborator for his research efforts. Together, they aim to uncover the regulatory role played by the mitochondria within the murine and human vascular endothelium. Andy’s project investigates the interaction between PGC-1alpha, a key player in mitochondrial biogenesis, and telomerase within the context of atherosclerotic disease. They hope to identify novel vascular targets to combat atherosclerosis.

David Chabowski

David Chabowski
Graduate Student
dchabowski@mcw.edu

As a graduate student in Dr. Gutterman’s lab, I am interested in endothelium-independent vascular pathophysiology. Currently, my focus lays in the area of ion channel-mediated hyperpolarization and relaxation of vascular smooth muscle cells in the microcirculation which is critical in regulating myocardial perfusion. Using cannulated vessels in combination with electrophysiological and molecular techniques, I plan to examine the role coronary artery disease (CAD) has in modulating voltage-activated potassium channel-mediated hyperpolarization of vascular smooth muscle cells and dilation of resistant coronary arterioles.

Daniela Didier

Daniela Didier
Lab Manager
ddidier@mcw.edu

Daniela Didier is a Lab Manager whose time is shared between Drs. David Gutterman, Andreas Beyer, Julie Freed, and David Zhang. In addition to administrative duties, Dani helps coordinate ongoing projects in the lab, tissue acquisition, and cell culture including in vitro model of angiogenesis.

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Alumni/Former Trainees

Joseph Hockenberry
Jasmine Linn
Victoria Nasci

Can improvement in hormonal and energy balance reverse cardiovascular risk factors in athletes with amenorrhea?

(Grosman-Rimon L, Wright E, Freedman D, Kachel E, Hui S, Epstein I, Gutterman D, Eilat-Adar S.) Am J Physiol Heart Circ Physiol. 2019 09 01;317(3):H487-H495.
Cardiac contractility modulation improves long-term survival and hospitalizations in heart failure with reduced ejection fraction.

(Anker SD, Borggrefe M, Neuser H, Ohlow MA, Röger S, Goette A, Remppis BA, Kuck KH, Najarian KB, Gutterman DD, Rousso B, Burkhoff D, Hasenfuss G.) Eur J Heart Fail. 2019 Sep;21(9):1103-1113.
Visualization and quantification of mitochondrial structure in the endothelium of intact arteries.

(Durand MJ, Ait-Aissa K, Levchenko V, Staruschenko A, Gutterman DD, Beyer AM.) Cardiovasc Res. 2019 Aug 01;115(10):1546-1556.
Low-Fat Diet Designed for Weight Loss But Not Weight Maintenance Improves Nitric Oxide-Dependent Arteriolar Vasodilation in Obese Adults.

(Mahmoud AM, Hwang CL, Szczurek MR, Bian JT, Ranieri C, Gutterman DD, Phillips SA.) Nutrients. 2019 Jun 14;11(6).
Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease.

(Ait-Aissa K, Blaszak SC, Beutner G, Tsaih SW, Morgan G, Santos JH, Flister MJ, Joyce DL, Camara AKS, Gutterman DD, Donato AJ, Porter GA Jr, Beyer AM.) Sci Rep. 2019 May 20;9(1):7623.
Two weeks of ischemic conditioning improves walking speed and reduces neuromuscular fatigability in chronic stroke survivors.

(Durand MJ, Boerger TF, Nguyen JN, Alqahtani SZ, Wright MT, Schmit BD, Gutterman DD, Hyngstrom AS.) J Appl Physiol (1985). 2019 Mar 01;126(3):755-763.
Lysophosphatidic acid acts on LPA receptor to increase H O during flow-induced dilation in human adipose arterioles.

(Chabowski DS, Kadlec AO, Ait-Aissa K, Hockenberry JC, Pearson PJ, Beyer AM, Gutterman DD.) Br J Pharmacol. 2018 11;175(22):4266-4280.
A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation.

(Abraham WT, Kuck KH, Goldsmith RL, Lindenfeld J, Reddy VY, Carson PE, Mann DL, Saville B, Parise H, Chan R, Wiegn P, Hastings JL, Kaplan AJ, Edelmann F, Luthje L, Kahwash R, Tomassoni GF, Gutterman DD, Stagg A, Burkhoff D, Hasenfuß G.) JACC Heart Fail. 2018 10;6(10):874-883.
Physiological Consequences of Coronary Arteriolar Dysfunction and Its Influence on Cardiovascular Disease.

(Allaqaband H, Gutterman DD, Kadlec AO.) Physiology (Bethesda). 2018 09 01;33(5):338-347.
Ischemic conditioning increases strength and volitional activation of paretic muscle in chronic stroke: a pilot study.

(Hyngstrom AS, Murphy SA, Nguyen J, Schmit BD, Negro F, Gutterman DD, Durand MJ.) J Appl Physiol (1985). 2018 05 01;124(5):1140-1147.
Telomerase reverse transcriptase protects against angiotensin II-induced microvascular endothelial dysfunction.

(Ait-Aissa K, Kadlec AO, Hockenberry J, Gutterman DD, Beyer AM.) Am J Physiol Heart Circ Physiol. 2018 05 01;314(5):H1053-H1060.
Regular Aerobic, Resistance, and Cross-Training Exercise Prevents Reduced Vascular Function Following a High Sugar or High Fat Mixed Meal in Young Healthy Adults.

(Das EK, Lai PY, Robinson AT, Pleuss J, Ali MM, Haus JM, Gutterman DD, Phillips SA.) Front Physiol. 2018;9:183.

Cardiovascular Center

Recent Publications