David Gutterman Lab
David Gutterman, MD
Northwestern Mutual Professor, Department of Medicine
Dr. Gutterman is actively involved in clinical practice, supervises a NIH funded research laboratory and provides senior administrative oversight of research administration at the Medical College of Wisconsin. He has served in a leadership role in a variety of national and international cardiovascular scientific organizations.
Research Technologist II
Within Dr. Gutterman’s lab my primary role is to collect and analyze experimental data for multiple research projects and to provide support where needed to meet the goals of the laboratory faculty. I have background in cell biology and regenerative medicine and an interest in genetics and physiology.
Andrew D. Kadlec, PhD
MD Student; Medical Scientist Training Program (MSTP)
Andy Kadlec is an MD/PhD student in the Medical Scientist Training Program (MSTP) at MCW. His research interests include studying vascular biology from a largely translational approach. In collaboration with Dr. David Gutterman, Dr. Beyer serves as a key mentor and collaborator for his research efforts. Together, they aim to uncover the regulatory role played by the mitochondria within the murine and human vascular endothelium. Andy’s project investigates the interaction between PGC-1alpha, a key player in mitochondrial biogenesis, and telomerase within the context of atherosclerotic disease. They hope to identify novel vascular targets to combat atherosclerosis.
As a graduate student in Dr. Gutterman’s lab, I am interested in endothelium-independent vascular pathophysiology. Currently, my focus lays in the area of ion channel-mediated hyperpolarization and relaxation of vascular smooth muscle cells in the microcirculation which is critical in regulating myocardial perfusion. Using cannulated vessels in combination with electrophysiological and molecular techniques, I plan to examine the role coronary artery disease (CAD) has in modulating voltage-activated potassium channel-mediated hyperpolarization of vascular smooth muscle cells and dilation of resistant coronary arterioles.
- Jasmine Linn
- Victoria Nasci
PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure.
(Kadlec AO, Chabowski DS, Ait-Aissa K, Hockenberry JC, Otterson MF, Durand MJ, Freed JK, Beyer AM, Gutterman DD.) Hypertension. 2017 07;70(1):166-173.
(Freed JK, Gutterman DD.) J Cardiovasc Pharmacol. 2017 May;69(5):264-272.
(Zinkevich NS, Fancher IS, Gutterman DD, Phillips SA.) Microcirculation. 2017 08;24(6).
(Durand MJ, Ait-Aissa K, Gutterman DD.) Circ Res. 2017 Apr 28;120(9):1379-1380.
(Freed JK, Durand MJ, Hoffmann BR, Densmore JC, Greene AS, Gutterman DD.) Am J Physiol Heart Circ Physiol. 2017 May 01;312(5):H1096-H1104.
(Levi-Rosenzvig R, Beyer AM, Hockenberry J, Ben-Shushan RS, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A.) Free Radic Biol Med. 2017 02;103:87-94.
(Beyer AM, Zinkevich N, Miller B, Liu Y, Wittenburg AL, Mitchell M, Galdieri R, Sorokin A, Gutterman DD.) Basic Res Cardiol. 2017 01;112(1):5.
(Yang L, Cheriyan J, Gutterman DD, Mayer RJ, Ament Z, Griffin JL, Lazaar AL, Newby DE, Tal-Singer R, Wilkinson IB.) Chest. 2017 Mar;151(3):555-563.
(Nishijima Y, Cao S, Chabowski DS, Korishettar A, Ge A, Zheng X, Sparapani R, Gutterman DD, Zhang DX.) Circ Res. 2017 Feb 17;120(4):658-669.
(Buchanan CE, Kadlec AO, Hoch AZ, Gutterman DD, Durand MJ.) Med Sci Sports Exerc. 2017 04;49(4):669-675.
(Somberg LB, Gutterman DD, Miura H, Nirula R, Hatoum OA.) Eur J Clin Invest. 2017 Jan;47(1):30-37.
(Durand MJ, Buchanan CE, Hoch AZ, Gutterman DD.) Med Sci Sports Exerc. 2016 May;48(5 Suppl 1):189-90.