Julie Freed Lab
Julie Freed, MD, PhDAssistant Professor, Department of Anesthesiology
Dr. Freed’s research primarily focuses on the role that sphingolipids have in the development of endothelial dysfunction in the human microcirculation. Elevated plasma levels of ceramide, a prototypical sphingolipid, is now considered an independent risk factor for major adverse cardiovascular events in otherwise healthy people. The Freed lab is currently investigating how these bioactive lipids are regulated in human endothelial cells.
As a cardiac anesthesiologist, Dr. Freed is also interested in intraoperative blood pressure control including mechanisms and treatments of vasoplegia. Other interests include translating her work in the lab to improve outcomes for surgical patients.
Research Technologist II
Her primary responsibility is to analyze vascular reactivity of human coronary arterioles and adipose microvessels to help elucidate differences in healthy vs. diseased vasculature. Specifically, she is investigating mediators that control the switch from a healthy vascular dilation response (nitric oxide) to a pro-inflammatory vascular dilation response (hydrogen peroxide). Mary is also studying novel treatments for bacterial-induced vasoplegia. Additionally, she manages the purchasing and budgeting, among other administrative responsibilities.
Kelsey graduated from the University of California, Davis with a Bachelor’s degree in Genetics in 2013. Prior to starting at MCW she spent a year in India doing public health research with the Center for Disease Dynamics Economics and Policy, and spent two years coordinating clinical trials for lymphoma treatments at Stanford’s Medical Center. She is currently a medical student in the class of 2020 at MCW.
In the Freed lab she is studying the mechanism behind hydroxocobalamin’s (Vitamin B12) treatment of vasoplegia, a state of refractory hypotension despite normal or high cardiac output. She is passionate about her work in Dr. Freed’s lab because of its direct application to clinical practice.
(Freed JK.) Circ Res. 2019 Jan 04;124(1):15-17.
(Pagel PS, Dye L 3rd, Hill GED, Vega JL, Tawil JN, De Vry DJ, Chandrashekarappa K, Iqbal Z, Boettcher BT, Freed JK.) J Vis Exp. 2018 Nov 28(141).
(Freed JK, Durand MJ.) Am J Physiol Heart Circ Physiol. 2018 Sep 01;315(3):H632-H633.
Advanced Age Attenuates Left Ventricular Filling Efficiency Quantified Using Vortex Formation Time: A Study of Octogenarians With Normal Left Ventricular Systolic Function Undergoing Coronary Artery Surgery.
(Pagel PS, Dye L 3rd, Boettcher BT, Freed JK.) J Cardiothorac Vasc Anesth. 2018 08;32(4):1775-1779.
(Dye L 3rd, Freed JK, Leschke JR, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 08;32(4):2031-2033.
(Freed JK, Simon JA, Iqbal Z, Almassi GH, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 06;32(3):1529-1532.
(Zundel MT, Feih JT, Rinka JRG, Boettcher BT, Freed JK, Kaiser M, Ghadiali HY, Tawil JN, Woehlck HJ, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 02;32(1):452-457.
(Freed JK, Dyer AJ, Olund TJ, Veldheer DJ, Boettcher BT, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 04;32(2):1090-1092.
(Boettcher BT, Mungara C, Manupipatpong KK, Freed JK, Kaiser M, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 02;32(1):600-602.
PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure.
(Kadlec AO, Chabowski DS, Ait-Aissa K, Hockenberry JC, Otterson MF, Durand MJ, Freed JK, Beyer AM, Gutterman DD.) Hypertension. 2017 07;70(1):166-173.
(Freed JK, Gutterman DD.) J Cardiovasc Pharmacol. 2017 May;69(5):264-272.
(Ebert TJ, Novalija J, Barney JA, Uhrich TD, Arain SR, Freed JK, Pagel PS.) J Cardiothorac Vasc Anesth. 2017 Oct;31(5):1649-1655.