Marcelo Bonini Lab

Marcelo Bonini, PhD
Principal Investigator; Professor, Medicine (Endocrinology)
mbonini@mcw.edu

Chenxia He, PhD
Assistant Professor, Medicine (Endocrinology)
ckhe@mcw.edu

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Hayley Lund
Lab Manager
hlund@mcw.edu

Jeanne Danes

Jeanne Danes
Research Technologist II
jdanes@mcw.edu

Yunping Huang

Yunping Huang
Research Technologist II
yuhuang@mcw.edu

Rodrigo Miguel

Rodrigo Miguel
Postdoctoral Fellow
rmiguel@mcw.edu

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Veronica Paviani Sampaio
Postdoctoral Fellow
vsampaio@mcw.edu

Diego Rodrigues Coelho
Postdoctoral Fellow
drodrigues@mcw.edu

Flavio Romero Palma
Postdoctoral Fellow
fpalma@mcw.edu

Cancer therapy-induced cardiovascular toxicity: old/new problems and old drugs.

(Beyer AM, Bonini MG, Moslehi J.) Am J Physiol Heart Circ Physiol. 2019 Jul 01;317(1):H164-H167.
Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension.

(Oliveira SDS, Chen J, Castellon M, Mao M, Raj JU, Comhair S, Erzurum S, Silva CLM, Machado RF, Bonini MG, Minshall RD.) Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1191-1202.
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.

(Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR.) Nature. 2019 04;568(7751):254-258.
Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells.

(Chen Z, D S Oliveira S, Zimnicka AM, Jiang Y, Sharma T, Chen S, Lazarov O, Bonini MG, Haus JM, Minshall RD.) Mol Biol Cell. 2018 05 15;29(10):1190-1202.
Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice.

(Ganini D, Santos JH, Bonini MG, Mason RP.) Cell Chem Biol. 2018 04 19;25(4):413-425.e6.
Environmental Toxicant Exposures and Type 2 Diabetes Mellitus: Two Interrelated Public Health Problems on the Rise.

(Bonini MG, Sargis RM.) Curr Opin Toxicol. 2018 Feb;7:52-59.
Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle.

(Mey JT, Blackburn BK, Miranda ER, Chaves AB, Briller J, Bonini MG, Haus JM.) Am J Physiol Regul Integr Comp Physiol. 2018 02 01;314(2):R181-R190.
Nitric oxide donor [Ru(terpy)(bdq)NO] induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production.

(Potje SR, Chen Z, Oliveira SDS, Bendhack LM, da Silva RS, Bonini MG, Antoniali C, Minshall RD.) Free Radic Biol Med. 2017 11;112:587-596.
Mitochondria targeting by environmental stressors: Implications for redox cellular signaling.

(Blajszczak C, Bonini MG.) Toxicology. 2017 11 01;391:84-89.
Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

(Zou X, Ratti BA, O'Brien JG, Lautenschlager SO, Gius DR, Bonini MG, Zhu Y.) J Bioenerg Biomembr. 2017 Aug;49(4):325-333.
Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR to promote metastasis.

(Kenny TC, Hart P, Ragazzi M, Sersinghe M, Chipuk J, Sagar MAK, Eliceiri KW, LaFramboise T, Grandhi S, Santos J, Riar AK, Papa L, D'Aurello M, Manfredi G, Bonini MG, Germain D.) Oncogene. 2017 08;36(31):4393-4404.
Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin.

(Ekoue DN, Bera S, Ansong E, Hart PC, Zaichick S, Domann FE, Bonini MG, Diamond AM.) Free Radic Res. 2017 Jun;51(6):582-590.

Cardiovascular Center

Marcelo Bonini Lab

Recent Publications