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Yu-Chieh (Jack) Wang, MD

Yu-Chieh (Jack) Wang, PhD

Assistant Professor

Locations

  • TBRC 3885 (Office)
    TBRC 3698 and 3645 (Lab)

Contact Information

General Interests

Cancer biology, stem cell biology, regenerative medicine, systems biology, glycobiology, experimental therapeutics

Education

PhD, Pharmacy (Medicinal Chemistry and Pharmacognosy), Ohio State University, Columbus, OH, 2008
BS, Department of Biology, National Taiwan Normal University, Taipei, Taiwan, 2002
Postdoctoral Research, The Scripps Research Institute, 2009-2014

Biography

Dr. Wang received his doctoral degree in medicinal chemistry and pharmacognosy from The Ohio State University. His early research was focused on the experimental therapeutics of human cancer and the regulation of kinase signaling using novel small molecules. In addition, he has led several studies at the interface of stem cell and cancer biology with emphases on posttranslational modification-mediated regulatory mechanisms underlying cellular pluripotency and the physio-pathological development of human pigment cells. As an American Cancer Society Research Scholar, Dr. Wang works with his group to provide new insights and resolutions to help overcome challenges in biomedical research and disease treatment. Using human stem cell-based platforms and studying regenerative medicine, they strive to have a better understanding of how these novel approaches can be leveraged to model or treat disease.

Honors and Awards

  • 2020 American Cancer Society (ACS) Research Scholar, American Cancer Society
  • 2012 Society of Fellows Postdoctoral Travel Award, The Scripps Research Institute
  • 2011 ISSCR Travel Award, International Society for Stem Cell Research (ISSCR)
  • 2009 Marie Mayer Fellow, Marie & Jimmy Mayer Award for Melanoma Research
  • 2007 NIH National Graduate Student Research Festival Travel Grant, National Institutes of Health
  • 2004 Outstanding Student Research Award, Department of Biology, National Taiwan Normal University
  • 2002 Outstanding Student Research Award, Department of Biology, National Taiwan Normal University

Research Experience

  • Antineoplastic Agents
  • Cell Survival
  • Cellular Reprogramming
  • Combined Modality Therapy
  • Congenital Disorders of Glycosylation
  • Developmental Biology
  • Endoplasmic Reticulum Stress
  • Gene Expression Regulation, Developmental
  • Glioblastoma
  • Glycosyltransferases
  • Human Embryonic Stem Cells
  • Induced Pluripotent Stem Cells

Methodologies and Techniques

  • Cell Line, Tumor
  • Cellular Reprogramming Techniques
  • CRISPR-Cas Systems
  • Culture Techniques
  • Drug Screening Assays, Antitumor
  • Gene Expression Profiling
  • Glycomics
  • Microarray Analysis
  • Models, Animal
  • Pluripotent Stem Cells
  • Proteomics
  • Single-Cell Analysis

Research Interests

Having my initial training as a cancer biologist followed by postdoctoral research in pluripotent stem cells and regenerative medicine, I am leading my research group to actively work at the interface of cancer and stem cell biology. We have established and leveraged cutting-edge platforms and approaches, including human pluripotent stem cells (hPSCs), cerebral organoids, animal models, gene editing, and systems biology techniques, to investigate signaling networks, neurodevelopmental abnormalities, and anticancer responses relevant to the alterations of glycoenzymes. We also maintain a long-standing interest in dissecting molecular mechanisms underlying the regulation of cellular pluripotency and differentiation in hPSCs, aiming to better harness hPSCs for regenerative medicine and disease modeling.

Publications