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Faculty Students Collaborate

Otoclinomics

Bringing the field of precision medicine to the field of otolaryngology. 

Otoclinomics Leadership Team

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David Friedland, MD, PhD

Professor & Vice-Chair, Department of Otolaryngology and Communication Sciences

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Jazzmyne Adams, MPH

Research Program Director, Department of Otolaryngology and Communication Sciences

About Otoclinomics

Medical practice is undergoing a dramatic shift from focusing on populations, a central tenet of evidence-based medicine, to focusing on the individual patient. There is increasing evidence that even seemingly straight-forward conditions can present and respond very differently from person to person. We are at a time in science when we can identify unique biological factors in an individual that may better inform their treatment options. This is termed precision medicine.

The principal goal of Otoclinomics is to bring precision medicine to the field of Otolaryngology by establishing a department-wide platform for collecting and analyzing demographic, biologic, physiologic, radiographic and disease-related data. In partnership with the MCW Genomic Sciences and Precision Medicine Center we will explore unique biological predictors of disease behavior and response to treatment. This will create person-specific, as opposed to disease-specific, guidelines for the management of common ear, nose, and throat disorders.


Precision Medicine

Areas of Precision Medicine to be explored within the field of Otolaryngology.
Microbiomics

Microbiomics

The microbiome is the entirety of microbial organisms that live on and within each person. Recent evidence indicates that the microbiome may be a key factor in the development of conditions as disparate as cardiovascular disease and depression. The microbiome may influence the development and response to treatment of ENT conditions, particularly those with an inflammatory component such as sinusitis or otitis media.
Genetics

Genetics

Many conditions develop or are pre-disposed due to inherited genes and mutations. Many different genes may lead to a common presentation, for example hearing loss, but treatment may be different based on the underlying genetic cause.
Epigenetics

Epigenetics

The DNA we are born with changes based upon our life experiences including stressors, activity levels, diet, and other diseases. Acquired modifications of a person’s genetic code may influence their development of ENT disorders and their responses to current treatments.
Pharmacogenetics

Pharmacogenetics

There is increasing evidence that a person’s response to medications can be influenced by their genes. Thus, different medications for the same disease may be needed for those with differing genomes. In addition, some ENT disorders, such as hearing loss or imbalance, may be caused by some medications due to an underlying genetic susceptibility.
Radiomics

Radiomics

Advances in imaging technology, computer modelling, and simulation can lead to precision tailoring of surgical treatments for the unique anatomy and biology of the individual patient.