Fernando Santos-Pinheiro, MD

Assistant Professor


  • Froedtert Hospital
  • Cancer Center - Froedtert Hospital
  • Cancer Center - Froedtert Menomonee Falls Hospital
  • Cancer Center - Drexel Town Square Health Center


  • Neuro-Oncology
  • Neurology


  • English, Portuguese

Cancer Center - Froedtert Hospital

Cancer Center - Froedtert Menomonee Falls Hospital

Drexel Town Square Health Center


  • MD - Doctor of Medicine

Clinical Expertise

  • Brain Neoplasms
  • Electroencephalography
  • Electromyography
  • Epilepsy
  • Neurophysiology
  • Transcranial Magnetic Stimulation

Research Interests

Non-Convulsive Status Epilepticus in cancer patients with altered mental status.

Collaborator: John F de Groot MD

Non-convulsive status epilepticus (NCSE) is a potentially treatable etiology of unexplained altered mental status (AMS) in cancer patients. NCSE may be under-recognized clinically making electroencephalogram (EEG) essential for diagnosis. The purpose of this study was to determine the incidence of NCSE among patients with cancer undergoing inpatient neurology consultation for AMS, and to characterize their clinical features. (collecting data)

The molecular characteristics of long-term survivors with glioblastoma who have been submitted to maintenance therapy with isotretinoin.

Collaborator: Alfred Yung, MD

A deep sequencing molecular analysis of long-term glioblastoma survivors (5 years or longer) who have been submitted to maintenance isotretinoin after standard therapy. (analyzing tissue)

Resection of the enhancing portion of the tumor vs extended resection in high-grade gliomas. What should we learn from Epilepsy Surgery concepts.

Collaborator: Sujit Prabhu, MD

Resection of the enhancing portion of high-grade gliomas is considered to be the best practice for the management of highly morbid and recurrent tumors. Nevertheless, often times tumors localized to the non-dominant hemisphere may allow the surgeon to extend the resection to a partial or total lobectomy as opposed to stay restricted to the enhancing portion. We aim to investigate the use electrophysiologic (scalp and intra-operative EEG monitoring, ECoG) and radiographic (connectome, MRS) tools to determine the functional status of the peri- lesional brain parenchyma. (collecting data)

The cause-effect relationship between discontinuation of antiepileptic drugs after surgical resection of low grade gliomas and breakthrough seizures.

Collaborator: Merry Chen, MD

Retrospective review of seizure outcome based on initiation and discontinuation of AED’s in low-grade glioma patients presenting or not with seizures prior to tumor diagnosis.

Multidisciplinary Management of Pituitary Carcinoma – The MD Anderson Cancer Center experience from 1994 through 2016.

Collaborator: Carlos Kamiya Matsuoka, MD

This will be the largest case series of pituitary carcinoma available in literature. A total of 15 patients treated and followed up long-term in this institution will be presented. A review of the literature will follow.