The Brain Injury Research Program works to frequently disseminate findings from ongoing projects in the literature. This is a summary of publications by Brain Injury Research faculty and staff since the program’s inception in 2011.
Baseline Performance of NCAA Athletes on a Concussion Assessment Battery: A Report from the CARE Consortium. Katz BP, Kudela M, Harezlak J, McCrea M, McAllister T, Broglio SP; CARE Consortium Investigators. Sports Med. 2018 Aug;48(8):1971-1985.
Advanced Biomarkers of Pediatric Mild Traumatic Brain Injury: Progress and Perils. Mayer AR, Kaushal M, Dodd AB, Hanlon FM, Shaff NA, Mannix R, Master CL, Leddy JJ, Stephenson D, Wertz CJ, Suelzer EM, Arbogast KB, Meier TB. Neurosci Biobehav Rev. 2018 Aug 9. pii: S0149-7634(18)30293-8.
Acute White-Matter Abnormalities in Sports-Related Concussion: A Diffusion Tensor Imaging Study from the NCAA-DoD CARE Consortium. Mustafi SM, Harezlak J, Koch KM, Nencka AS, Meier TB, West JD, Giza CC, DiFiori JP, Guskiewicz KM, Mihalik JP, LaConte SM, Duma SM, Broglio SP, Saykin AJ, McCrea M, McAllister TW, Wu YC. J Neurotrauma. 2018 Aug 15. [Epub ahead of print]
Modeling the Structure of Acute Sport-Related Concussion Symptoms: A Bifactor Approach. Nelson LD, Kramer MD, Patrick CJ, McCrea MA. J Int Neuropsychol Soc. 2018 Aug 6:1-12. [Epub ahead of print]
Stability of MRI metrics in the advanced research core of the NCAA-DoD concussion assessment, research and education (CARE) consortium. Nencka AS, Meier TB, Wang Y, Muftuler LT, Wu YC, Saykin AJ, Harezlak J, Brooks MA, Giza CC, Difiori J, Guskiewicz KM, Mihalik JP, LaConte SM, Duma SM, Broglio S, McAllister T, McCrea MA, Koch KM. Brain Imaging Behav. 2018 Aug;12(4):1121-1140.
National Institute of Neurological Disorders and Stroke and Department of Defense Sport-Related Concussion Common Data Elements Version 1.0 Recommendations. Broglio SP, Kontos AP, Levin H, Schneider K, Wilde EA, Cantu RC, Feddermann-Demont N, Fuller GW, Gagnon I, Gioia GA, Giza C, Griesbach GS, Leddy JJ, Lipton ML, Mayer AR, McAllister TW, McCrea M, McKenzie LB, Putukian M, Signoretti S, Suskauer SJ, Tamburro R, Turner M, Yeates KO, Zemek R, Ala’i S, Esterlitz J, Gay K, Bellgowan PSF, Joseph K. J Neurotrauma. 2018 Jul 23. [Epub ahead of print]
Quantifying the Value of Multidimensional Assessment Models for Acute Concussion: An Analysis of Data from the NCAA-DoD Care Consortium. Garcia GP, Broglio SP, Lavieri MS, McCrea M, McAllister T; CARE Consortium Investigators. Sports Med. 2018 Jul;48(7):1739-1749.
Quantitative Susceptibility Mapping after Sports-Related Concussion. Koch KM, Meier TB, Karr R, Nencka AS, Muftuler LT, McCrea M. AJNR Am J Neuroradiol. 2018 Jul;39(7):1215-1221.
Chronic differences in white matter integrity following sport-related concussion as measured by diffusion MRI: 6-Month follow-up. Lancaster MA, Meier TB, Olson DV, McCrea MA, Nelson LD, Muftuler LT. Hum Brain Mapp. 2018 Jul 2. [Epub ahead of print]
Association Between History of Multiple Concussions and Health Outcomes Among Former College Football Players: 15-Year Follow-up From the NCAA Concussion Study (1999-2001). Kerr ZY, Thomas LC, Simon JE, McCrea M, Guskiewicz KM. Am J Sports Med. 2018 Jun;46(7):1733-1741.
Influences of Mental Illness, Current Psychological State, and Concussion History on Baseline Concussion Assessment Performance. Weber ML, Dean JL, Hoffman NL, Broglio SP, McCrea M, McAllister TW, Schmidt JD; CARE Consortium Investigators, Hoy AR, Hazzard JB, Kelly LA, Ortega JD, Port N, Putukian M, Langford TD, Tierney R, Campbell DE, McGinty G, O’Donnell P, Svoboda SJ, DiFiori JP, Giza CC, Benjamin HJ, Buckley T, Kaminski TW, Clugston JR, Feigenbaum LA, Eckner JT, Guskiewicz K, Mihalik JP, Miles JD, Anderson S, Master CL, Collins M, Kontos AP, Bazarian JJ, Chrisman SPD, Brooks A, Duma S, Bullers CT, Miles CM, Dykhuizen BH. Am J Sports Med. 2018 Jun;46(7):1742-1751.
Optimizing Outcome Assessment in Multicenter TBI Trials: Perspectives From TRACK-TBI and the TBI Endpoints Development Initiative. Bodien YG, McCrea M, Dikmen S, Temkin N, Boase K, Machamer J, Taylor SR, Sherer M, Levin H, Kramer JH, Corrigan JD, McAllister TW, Whyte J, Manley GT, Giacino JT; TRACK-TBI Investigators. J Head Trauma Rehabil. 2018 May/Jun;33(3):147-157.
Test-Retest Reliability and Interpretation of Common Concussion Assessment Tools: Findings from the NCAA-DoD CARE Consortium. Broglio SP, Katz BP, Zhao S, McCrea M, McAllister T; CARE Consortium Investigators. Sports Med. 2018 May;48(5):1255-1268. Erratum in: Sports Med. 2018 Jul;48(7):1761.
Neurosensory Deficits Vary as a Function of Point of Care in Pediatric Mild Traumatic Brain Injury. Mayer AR, Wertz C, Ryman SG, Storey EP, Park G, Phillips J, Dodd AB, Oglesbee S, Campbell R, Yeo RA, Wasserott B, Shaff NA, Leddy JJ, Mannix R, Arbogast KB, Meier TB, Grady MF, Master CL. J Neurotrauma. 2018 May 15;35(10):1178-1184.
Association of acute depressive symptoms and functional connectivity of emotional processing regions following sport-related concussion. McCuddy WT, España LY, Nelson LD, Birn RM, Mayer AR, Meier TB. Neuroimage Clin. 2018 May 9;19:434-442.
Immediate Removal From Activity After Sport-Related Concussion Is Associated With Shorter Clinical Recovery and Less Severe Symptoms in Collegiate Student-Athletes. Asken BM, Bauer RM, Guskiewicz KM, McCrea MA, Schmidt JD, Giza CC, Snyder AR, Houck ZM, Kontos AP, McAllister TW, Broglio SP, Clugston JR; CARE Consortium Investigators, Anderson S, Bazarian J, Brooks A, Buckley T, Chrisman S, Collins M, DiFiori J, Duma S, Dykhuizen B, Eckner JT, Feigenbaum L, Hoy A, Kelly L, Langford TD, Lintner L, McGinty G, Mihalik J, Miles C, Ortega J, Port N, Putukian M, Rowson S, Svoboda S. Am J Sports Med. 2018 May;46(6):1465-1474.
Age at First Concussion Influences the Number of Subsequent Concussions. Schmidt JD, Rizzone K, Hoffman NL, Weber ML, Jones C, Bazarian J, Broglio SP, McCrea M, McAllister TW; CARE Consortium Investigators. Pediatr Neurol. 2018 Apr;81:19-24.
Descriptive Analysis of a Baseline Concussion Battery Among U.S. Service Academy Members: Results from the Concussion Assessment, Research, and Education (CARE) Consortium. O’Connor KL, Dain Allred C, Cameron KL, Campbell DE, D’Lauro CJ, Houston MN, Johnson BR, Kelly TF, McGinty G, O’Donnell PG, Peck KY, Svoboda SJ, Pasquina P, McAllister T, McCrea M, Broglio SP. Mil Med. 2018 Mar 28. [Epub ahead of print]
Spatial distribution bias in subject-specific abnormalities analyses. Dodd AB, Ling JM, Bedrick EJ, Meier TB, Mayer AR. Brain Imaging Behav. 2018 Feb 13. [Epub ahead of print]
Correlation of Concussion Symptom Profile with Head Impact Biomechanics: A Case for Individual-Specific Injury Tolerance. Rowson S, Duma SM, Stemper BD, Shah A, Mihalik JP, Harezlak J, Riggen LD, Giza CC, DiFiori JP, Brooks A, Guskiewicz K, Campbell D, McGinty G, Svoboda SJ, Cameron KL, Broglio SP, McAllister TW, McCrea M. J Neurotrauma. 2018 Feb 15;35(4):681-690.
Acute Clinical Predictors of Symptom Recovery in Emergency Department Patients with Uncomplicated Mild Traumatic Brain Injury or Non-Traumatic Brain Injuries. Nelson LD, Furger RE, Ranson J, Tarima S, Hammeke TA, Randolph C, Barr WB, Guskiewicz K, Olsen CM, Lerner EB, McCrea MA. J Neurotrauma. 2018 Jan 15;35(2):249-259.
Kynurenic acid is reduced in females and oral contraceptive users: Implications for depression. Meier TB, Drevets WC, Teague TK, Wurfel BE, Mueller SC, Bodurka J, Dantzer R, Savitz J. Brain Behav Immun. 2018 Jan;67:59-64.
Parental Knowledge and Recall of Concussion Discharge Instructions. Thomas DG, Bradley L, Servi A, Reilly S, Niskala Apps J, McCrea M, Hammeke T. J Emerg Nurs. 2018 Jan;44(1):52-56.
Influence of Postconcussion Sleep Duration on Concussion Recovery in Collegiate Athletes. Hoffman NL, Weber ML, Broglio SP, McCrea M, McAllister TW, Schmidt JD; CARE Consortium Investigators. Clin J Sport Med. 2017 Nov 16. [Epub ahead of print]
Infographic: Consensus statement on concussion in sport. McCrory P, Meeuwisse W, Dvorak J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ, Castellani RJ, Davis GA, Ellenbogen R, Emery C, Engebretsen L, Feddermann-Demont N, Giza CC, Guskiewicz KM, Herring S, Iverson GL, Johnston KM, Kissick J, Kutcher J, Leddy JJ, Maddocks D, Makdissi M, Manley G, McCrea M, Meehan WP, Nagahiro S, Patricios J, Putukian M, Schneider KJ, Sills A, Tator CH, Turner M, Vos PE. Br J Sports Med. 2017 Nov;51(21):1557-1558.
Prospective Assessment of Acute Blood Markers of Brain Injury in Sport-Related Concussion. Meier TB, Nelson LD, Huber DL, Bazarian JJ, Hayes RL, McCrea MA. J Neurotrauma. 2017 Nov 15;34(22):3134-3142.
Head Impact Density: A Model To Explain the Elusive Concussion Threshold. Broglio SP, Lapointe A, O’Connor KL, McCrea M. J Neurotrauma. 2017 Oct 1;34(19):2675-2683.
Risk Factors for Prolonged Symptoms of Mild Traumatic Brain Injury: A Pediatric Sports Concussion Clinic Cohort. Fehr SD, Nelson LD, Scharer KR, Traudt EA, Veenstra JM, Tarima SS, Liu XC, Walter KD. Clin J Sport Med. 2017 Oct 27. [Epub ahead of print]
The Biological Basis of Chronic Traumatic Encephalopathy following Blast Injury: A Literature Review. Aldag M, Armstrong RC, Bandak F, Bellgowan PSF, Bentley T, Biggerstaff S, Caravelli K, Cmarik J, Crowder A, DeGraba TJ, Dittmer TA, Ellenbogen RG, Greene C, Gupta RK, Hicks R, Hoffman S, Latta RC 3rd, Leggieri MJ Jr, Marion D, Mazzoli R, McCrea M, O’Donnell J, Packer M, Petro JB, Rasmussen TE, Sammons-Jackson W, Shoge R, Tepe V, Tremaine LA, Zheng J. J Neurotrauma. 2017 Sep;34(S1):S26-S43.
Neuropsychological Screening of Sport-Related Concussion. McCrea MA, Asken B, Nelson LD. Neurol Clin. 2017 Aug;35(3):487-500.
A National Study on the Effects of Concussion in Collegiate Athletes and US Military Service Academy Members: The NCAA-DoD Concussion Assessment, Research and Education (CARE) Consortium Structure and Methods. Broglio SP, McCrea M, McAllister T, Harezlak J, Katz B, Hack D, Hainline B; CARE Consortium Investigators. Sports Med. 2017 Jul;47(7):1437-1451.
Baseline Performance and Psychometric Properties of the Child Sport Concussion Assessment Tool 3 (Child-SCAT3) in 5- to 13-year-old Athletes. Nelson LD, Loman MM, LaRoche AA, Furger RE, McCrea MA. Clin J Sport Med. 2017 Jul;27(4):381-387.
The Sport Concussion Assessment Tool 5th Edition (SCAT5): Background and rationale. Echemendia RJ, Meeuwisse W, McCrory P, Davis GA, Putukian M, Leddy J, Makdissi M, Sullivan SJ, Broglio SP, Raftery M, Schneider K, Kissick J, McCrea M, Dvořák J, Sills AK, Aubry M, Engebretsen L, Loosemore M, Fuller G, Kutcher J, Ellenbogen R, Guskiewicz K, Patricios J, Herring S. Br J Sports Med. 2017 Jun;51(11):848-850.
The Concussion Recognition Tool 5th Edition (CRT5): Background and rationale. Echemendia RJ, Meeuwisse W, McCrory P, Davis GA, Putukian M, Leddy J, Makdissi M, Sullivan SJ, Broglio SP, Raftery M, Schneider K, Kissick J, McCrea M, Dvořák J, Sills AK, Aubry M, Engebretsen L, Loosemore M, Fuller G, Kutcher J, Ellenbogen R, Guskiewicz K, Patricios J, Herring S. Br J Sports Med. 2017 Jun;51(11):870-871.
What is the physiological time to recovery after concussion? A systematic review. Kamins J, Bigler E, Covassin T, Henry L, Kemp S, Leddy JJ, Mayer A, McCrea M, Prins M, Schneider KJ, Valovich McLeod TC, Zemek R, Giza CC. Br J Sports Med. 2017 Jun;51(12):935-940.
Approach to investigation and treatment of persistent symptoms following sport-related concussion: a systematic review. Makdissi M, Schneider KJ, Feddermann-Demont N, Guskiewicz KM, Hinds S, Leddy JJ, McCrea M, Turner M, Johnston KM. Br J Sports Med. 2017 Jun;51(12):958-968.
A prospective microstructure imaging study in mixed-martial artists using geometric measures and diffusion tensor imaging: methods and findings. Mayer AR, Ling JM, Dodd AB, Meier TB, Hanlon FM, Klimaj SD. Brain Imaging Behav. 2017 Jun;11(3):698-711.
Role of advanced neuroimaging, fluid biomarkers and genetic testing in the assessment of sport-related concussion: a systematic review. McCrea M, Meier T, Huber D, Ptito A, Bigler E, Debert CT, Manley G, Menon D, Chen JK, Wall R, Schneider KJ, McAllister T. Br J Sports Med. 2017 Jun;51(12):919-929.
Consensus statement on concussion in sport-the 5th international conference on concussion in sport held in Berlin, October 2016. McCrory P, Meeuwisse W, Dvořák J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ, Castellani RJ, Davis GA, Ellenbogen R, Emery C, Engebretsen L, Feddermann-Demont N, Giza CC, Guskiewicz KM, Herring S, Iverson GL, Johnston KM, Kissick J, Kutcher J, Leddy JJ, Maddocks D, Makdissi M, Manley GT, McCrea M, Meehan WP, Nagahiro S, Patricios J, Putukian M, Schneider KJ, Sills A, Tator CH, Turner M, Vos PE. Br J Sports Med. 2017 Jun;51(11):838-847.
5th International Conference on Concussion in Sport (Berlin). McCrory P, Meeuwisse WH, Dvořák J, Echemendia RJ, Engebretsen L, Feddermann-Demont N, McCrea M, Makdissi M, Patricios J, Schneider KJ, Sills AK. Br J Sports Med. 2017 Jun;51(11):837.
Validating Multidimensional Outcome Assessment Using the TBI Common Data Elements: An Analysis of the TRACK-TBI Pilot Sample. Nelson LD, Ranson J, Ferguson AR, Giacino J, Okonkwo DO, Valadka A, Manley G, McCrea M. J Neurotrauma. 2017 Jun 8. [Epub ahead of print]
What are the critical elements of sideline screening that can be used to establish the diagnosis of concussion? A systematic review. Patricios J, Fuller GW, Ellenbogen R, Herring S, Kutcher JS, Loosemore M, Makdissi M, McCrea M, Putukian M, Schneider KJ. Br J Sports Med. 2017 Jun;51(11):888-894.
Rest and treatment/rehabilitation following sport-related concussion: a systematic review. Schneider KJ, Leddy JJ, Guskiewicz KM, Seifert T, McCrea M, Silverberg ND, Feddermann-Demont N, Iverson GL, Hayden A, Makdissi M. Br J Sports Med. 2017 Jun;51(12):930-934.
The Effectiveness of Prescribed Rest Depends on Initial Presentation After Concussion. Sufrinko AM, Kontos AP, Apps JN, McCrea M, Hickey RW, Collins MW, Thomas DG. J Pediatr. 2017 Jun;185:167-172.
Diagnosis and Management of Acute Concussion. McCrea MA, Nelson LD, Guskiewicz K. Phys Med Rehabil Clin N Am. 2017 May;28(2):271-286.
Evidence of a prominent genetic basis for associations between psychoneurometric traits and common mental disorders. Venables NC, Hicks BM, Yancey JR, Kramer MD, Nelson LD, Strickland CM, Krueger RF, Iacono WG, Patrick CJ. Int J Psychophysiol. 2017 May;115:4-12.
Prospective, Head-to-Head Study of Three Computerized Neurocognitive Assessment Tools Part 2: Utility for Assessment of Mild Traumatic Brain Injury in Emergency Department Patients. Nelson LD, Furger RE, Gikas P, Lerner EB, Barr WB, Hammeke TA, Randolph C, Guskiewicz K, McCrea MA. J Int Neuropsychol Soc. 2017 Apr;23(4):293-303.
The Traumatic Brain Injury Endpoints Development (TED) Initiative: Progress on a Public-Private Regulatory Collaboration to Accelerate Diagnosis and Treatment of Traumatic Brain Injury. Manley GT, MacDonald CL, Markowitz A, Stephenson D, Robbins A, Gardner RC, Winkler EA, Bodien Y, Taylor S, Yue JK, Kannan L, Kumar A, McCrea M, Wang KKW. J Neurotrauma. 2017 Mar 31. [Epub ahead of print]
Long-Term Cognitive and Neuropsychiatric Consequences of Repetitive Concussion and Head-Impact Exposure. McAllister T, McCrea M. J Athl Train. 2017 Mar;52(3):309-317.
Predicting Recovery Patterns After Sport-Related Concussion. Teel EF, Marshall SW, Shankar V, McCrea M, Guskiewicz KM. J Athl Train. 2017 Mar;52(3):288-298.
Longitudinal assessment of local and global functional connectivity following sports-related concussion. Meier TB, Bellgowan PSF, Mayer AR. Brain Imaging Behav. 2017 Feb;11(1):129-140.
Abnormalities in Functional Connectivity in Collegiate Football Athletes with and without a Concussion History: Implications and Role of Neuroactive Kynurenine Pathway Metabolites. Meier TB, Lancaster MA, Mayer AR, Teague TK, Savitz J. J Neurotrauma. 2017 Feb 15;34(4):824-837.
Developing a Cognition Endpoint for Traumatic Brain Injury Clinical Trials. Silverberg ND, Crane PK, Dams-O’Connor K, Holdnack J, Ivins BJ, Lange RT, Manley GT, McCrea M, Iverson GL. J Neurotrauma. 2017 Jan 15;34(2):363-371.
Statements of Agreement From the Targeted Evaluation and Active Management (TEAM) Approaches to Treating Concussion Meeting Held in Pittsburgh, October 15-16, 2015. Collins MW, Kontos AP, Okonkwo DO, Almquist J, Bailes J, Barisa M, Bazarian J, Bloom OJ, Brody DL, Cantu R, Cardenas J, Clugston J, Cohen R, Echemendia R, Elbin RJ, Ellenbogen R, Fonseca J, Gioia G, Guskiewicz K, Heyer R, Hotz G, Iverson GL, Jordan B, Manley G, Maroon J, McAllister T, McCrea M, Mucha A, Pieroth E, Podell K, Pombo M, Shetty T, Sills A, Solomon G, Thomas DG, Valovich McLeod TC, Yates T, Zafonte R. Neurosurgery. 2016 Dec;79(6):912-929.
Acute white matter changes following sport-related concussion: A serial diffusion tensor and diffusion kurtosis tensor imaging study. Lancaster MA, Olson DV, McCrea MA, Nelson LD, LaRoche AA, Muftuler LT. Hum Brain Mapp. 2016 Nov;37(11):3821-3834.
Frequency and Outcomes of a Symptom-Free Waiting Period After Sport-Related Concussion. Pfaller AY, Nelson LD, Apps JN, Walter KD, McCrea MA. Am J Sports Med. 2016 Nov;44(11):2941-2946.
Prediction of Post-Concussive Behavioral Changes in a Rodent Model Based on Head Rotational Acceleration Characteristics. Stemper BD, Shah AS, Chiariello R, Olsen CM, Budde MD, Glavaski-Joksimovic A, McCrea M, Kurpad SN, Pintar FA. Ann Biomed Eng. 2016 Nov;44(11):3252-3265.
Activity-Related Symptom Exacerbations After Pediatric Concussion. Silverberg ND, Iverson GL, McCrea M, Apps JN, Hammeke TA, Thomas DG. JAMA Pediatr. 2016 Oct 1;170(10):946-953.
Reliability and Validity of the Sport Concussion Assessment Tool-3 (SCAT3) in High School and Collegiate Athletes. Chin EY, Nelson LD, Barr WB, McCrory P, McCrea MA. Am J Sports Med. 2016 Sep;44(9):2276-85.
Smaller Dentate Gyrus and CA2 and CA3 Volumes Are Associated with Kynurenine Metabolites in Collegiate Football Athletes. Meier TB, Savitz J, Singh R, Teague TK, Bellgowan PS. J Neurotrauma. 2016 Jul 15;33(14):1349-57.
Cerebral Blood Flow Alterations in Acute Sport-Related Concussion. Wang Y, Nelson LD, LaRoche AA, Pfaller AY, Nencka AS, Koch KM, McCrea MA. J Neurotrauma. 2016 Jul 1;33(13):1227-36.
Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion. Singh R, Savitz J, Teague TK, Polanski DW, Mayer AR, Bellgowan PS, Meier TB. J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):670-5.
Age-Related Changes in BOLD Activation Pattern in Phonemic Fluency Paradigm: An Investigation of Activation, Functional Connectivity and Psychophysiological Interactions. La C, Garcia-Ramos C, Nair VA, Meier TB, Farrar-Edwards D, Birn R, Meyerand ME, Prabhakaran V. Front Aging Neurosci. 2016 May 23;8:110.
Preinjury somatization symptoms contribute to clinical recovery after sport-related concussion. Nelson LD, Tarima S, LaRoche AA, Hammeke TA, Barr WB, Guskiewicz K, Randolph C, McCrea MA. Neurology. 2016 May 17;86(20):1856-63.
“Playing Through It”: Delayed Reporting and Removal From Athletic Activity After Concussion Predicts Prolonged Recovery. Asken BM, McCrea MA, Clugston JR, Snyder AR, Houck ZM, Bauer RM. J Athl Train. 2016 Apr;51(4):329-35.
Frequency of Factors that Complicate the Identification of Mild Traumatic Brain Injury in Level I Trauma Center Patients. Furger RE, Nelson LD, Lerner EB, McCrea MA. Concussion. 2016 Mar;1(2). pii: CNC11.
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Meier TB, Drevets WC, Wurfel BE, Ford BN, Morris HM, Victor TA, Bodurka J, Teague TK, Dantzer R, Savitz J. Brain Behav Immun. 2016 Mar;53:39-48.
Multiple Self-Reported Concussions Are More Prevalent in Athletes With ADHD and Learning Disability. Nelson LD, Guskiewicz KM, Marshall SW, Hammeke T, Barr W, Randolph C, McCrea MA. Clin J Sport Med. 2016 Mar;26(2):120-7.
Behavioral Outcomes Differ between Rotational Acceleration and Blast Mechanisms of Mild Traumatic Brain Injury. Stemper BD, Shah AS, Budde MD, Olsen CM, Glavaski-Joksimovic A, Kurpad SN, McCrea M, Pintar FA. Front Neurol. 2016 Mar 14;7:31.
Psychometric properties and normative data for the Brief Symptom Inventory-18 (BSI-18) in high school and collegiate athletes. Lancaster MA, McCrea MA, Nelson LD. Clin Neuropsychol. 2016 Feb;30(2):338-50.
Thinner Cortex in Collegiate Football Players With, but not Without, a Self-Reported History of Concussion. Meier TB, Bellgowan PS, Bergamino M, Ling JM, Mayer AR. J Neurotrauma. 2016 Feb 15;33(4):330-8.
Longitudinal assessment of white matter abnormalities following sports-related concussion. Meier TB, Bergamino M, Bellgowan PS, Teague TK, Ling JM, Jeromin A, Mayer AR. Hum Brain Mapp. 2016 Feb;37(2):833-45.
Age Differences in Recovery After Sport-Related Concussion: A Comparison of High School and Collegiate Athletes. Nelson LD, Guskiewicz KM, Barr WB, Hammeke TA, Randolph C, Ahn KW, Wang Y, McCrea MA. J Athl Train. 2016 Feb;51(2):142-52.
Neurobehavioral Traits as Transdiagnostic Predictors of Clinical Problems. Nelson LD, Strickland C, Krueger RF, Arbisi PA, Patrick CJ. Assessment. 2016 Feb;23(1):75-85.
Sport-Related Concussion Reporting and State Legislative Effects. LaRoche AA, Nelson LD, Connelly PK, Walter KD, McCrea MA. Clin J Sport Med. 2016 Jan;26(1):33-9.
Prospective, Head-to-Head Study of Three Computerized Neurocognitive Assessment Tools (CNTs): Reliability and Validity for the Assessment of Sport-Related Concussion. Nelson LD, LaRoche AA, Pfaller AY, Lerner EB, Hammeke TA, Randolph C, Barr WB, Guskiewicz K, McCrea MA. J Int Neuropsychol Soc. 2016 Jan;22(1):24-37.
Epidemiology of sports-related concussion in seven US high school and collegiate sports. Marshall SW, Guskiewicz KM, Shankar V, McCrea M, Cantu RC. Inj Epidemiol. 2015 Dec;2(1):13.
False-Positive Rates of Reliable Change Indices for Concussion Test Batteries: A Monte Carlo Simulation. Nelson LD. J Athl Train. 2015 Dec;50(12):1319-22.
Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder. Savitz J, Dantzer R, Meier TB, Wurfel BE, Victor TA, McIntosh SA, Ford BN, Morris HM, Bodurka J, Teague TK, Drevets WC. Psychoneuroendocrinology. 2015 Dec;62:54-8.
A functional magnetic resonance imaging study of cognitive control and neurosensory deficits in mild traumatic brain injury. Mayer AR, Hanlon FM, Dodd AB, Ling JM, Klimaj SD, Meier TB. Hum Brain Mapp. 2015 Nov;36(11):4394-406.
A Longitudinal Assessment of Structural and Chemical Alterations in Mixed Martial Arts Fighters. Mayer AR, Ling JM, Dodd AB, Gasparovic C, Klimaj SD, Meier TB. J Neurotrauma. 2015 Nov 15;32(22):1759-67.
Rates and Predictors of Invalid Baseline Test Performance in High School and Collegiate Athletes for 3 Computerized Neurocognitive Tests: ANAM, Axon Sports, and ImPACT. Nelson LD, Pfaller AY, Rein LE, McCrea MA. Am J Sports Med. 2015 Aug;43(8):2018-26.
Time-frequency theta and delta measures index separable components of feedback processing in a gambling task. Bernat EM, Nelson LD, Baskin-Sommers AR. Psychophysiology. 2015 May;52(5):626-37.
Head rotational acceleration characteristics influence behavioral and diffusion tensor imaging outcomes following concussion. Stemper BD, Shah AS, Pintar FA, McCrea M, Kurpad SN, Glavaski-Joksimovic A, Olsen C, Budde MD. Ann Biomed Eng. 2015 May;43(5):1071-88.
Sports concussion assessment and management: future research directions. McCrea M, Broshek DK, Barth JT. Brain Inj. 2015;29(2):276-82.
Benefits of strict rest after acute concussion: a randomized controlled trial. Thomas DG, Apps JN, Hoffmann RG, McCrea M, Hammeke T. Pediatrics. 2015 Feb;135(2):213-23.
Concussion: Key stakeholders and multidisciplinary participation in making sports safe. Guskiewicz K, Teel E, McCrea M. Neurosurgery. 2014 Oct;75 Suppl 4:S113-8.
Protective equipment and player characteristics associated with the incidence of sport-related concussion in high school football players: a multifactorial prospective study. McGuine TA, Hetzel S, McCrea M, Brooks MA. Am J Sports Med. 2014 Oct;42(10):2470-8.
Day of injury cognitive performance on the Military Acute Concussion Evaluation (MACE) by U.S. military service members in OEF/OIF. McCrea M, Guskiewicz K, Doncevic S, Helmick K, Kennedy J, Boyd C, Asmussen S, Ahn KW, Wang Y, Hoelzle J, Jaffee M. Mil Med. 2014 Sep;179(9):990-7.
Perceptual properties of feedback stimuli influence the feedback-related negativity in the flanker gambling task. Liu Y, Nelson LD, Bernat EM, Gehring WJ. Psychophysiology. 2014 Aug;51(8):782-8.
Evidence-based management of sport-related concussion. McCrea M, Guskiewicz K. Prog Neurol Surg. 2014;28:112-27.
Acute clinical recovery from sport-related concussion. Nelson LD, Janecek JK, McCrea MA. Neuropsychol Rev. 2013 Dec;23(4):285-99.
Computerized neurocognitive testing in the management of sport-related concussion: an update. Resch JE, McCrea MA, Cullum CM. Neuropsychol Rev. 2013 Dec;23(4):335-49.
Primary blast traumatic brain injury in the rat: relating diffusion tensor imaging and behavior. Budde MD, Shah A, McCrea M, Cullinan WE, Pintar FA, Stemper BD. Front Neurol. 2013 Oct 14;4:154.
Acute and subacute changes in neural activation during the recovery from sport-related concussion. Hammeke TA, McCrea M, Coats SM, Verber MD, Durgerian S, Flora K, Olsen GS, Leo PD, Gennarelli TA, Rao SM. J Int Neuropsychol Soc. 2013 Sep;19(8):863-72.
A construct-network approach to bridging diagnostic and physiological domains: application to assessment of externalizing psychopathology. Patrick CJ, Venables NC, Yancey JR, Hicks BM, Nelson LD, Kramer MD. J Abnorm Psychol. 2013 Aug;122(3):902-16
Time course of clinical and electrophysiological recovery after sport-related concussion. Prichep LS, McCrea M, Barr W, Powell M, Chabot RJ. J Head Trauma Rehabil. 2013 Jul-Aug;28(4):266-73.
Reliable change, sensitivity, and specificity of a multidimensional concussion assessment battery: implications for caution in clinical practice. Register-Mihalik JK, Guskiewicz KM, Mihalik JP, Schmidt JD, Kerr ZY, McCrea MA. J Head Trauma Rehabil. 2013 Jul-Aug;28(4):274-83.
Recovery of posttraumatic migraine characteristics in patients after mild traumatic brain injury. Mihalik JP, Register-Mihalik J, Kerr ZY, Marshall SW, McCrea M, Guskiewicz KM. Am J Sports Med. 2013 Jul;41(7):1490-6.
Advances in neuropsychological assessment of sport-related concussion. Echemendia RJ, Iverson GL, McCrea M, Macciocchi SN, Gioia GA, Putukian M, Comper P. Br J Sports Med. 2013 Apr;47(5):294-8.
Evidence-based approach to revising the SCAT2: introducing the SCAT3. Guskiewicz KM, Register-Mihalik J, McCrory P, McCrea M, Johnston K, Makdissi M, Dvorák J, Davis G, Meeuwisse W. Br J Sports Med. 2013 Apr;47(5):289-93.
Day of injury assessment of sport-related concussion. McCrea M, Iverson GL, Echemendia RJ, Makdissi M, Raftery M. Br J Sports Med. 2013 Apr;47(5):272-84.
Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012. McCrory P, Meeuwisse WH, Aubry M, Cantu B, Dvorák J, Echemendia RJ, Engebretsen L, Johnston K, Kutcher JS, Raftery M, Sills A, Benson BW, Davis GA, Ellenbogen RG, Guskiewicz K, Herring SA, Iverson GL, Jordan BD, Kissick J, McCrea M, McIntosh AS, Maddocks D, Makdissi M, Purcell L, Putukian M, Schneider K, Tator CH, Turner M. Br J Sports Med. 2013 Apr;47(5):250-8
Incidence, clinical course, and predictors of prolonged recovery time following sport-related concussion in high school and college athletes. McCrea M, Guskiewicz K, Randolph C, Barr WB, Hammeke TA, Marshall SW, Powell MR, Woo Ahn K, Wang Y, Kelly JP. J Int Neuropsychol Soc. 2013 Jan;19(1):22-33.
Role of neuropsychologists in the evaluation and management of sport-related concussion: an inter-organization position statement. Echemendia RJ, Iverson GL, McCrea M, Broshek DK, Gioia GA, Sautter SW, Macciocchi SN, Barr WB. Clin Neuropsychol. 2011 Nov;25(8):1289-94.
Neuropsychological assessment: a valuable tool in the diagnosis and management of neurological, neurodevelopmental, medical, and psychiatric disorders. Braun M, Tupper D, Kaufmann P, McCrea M, Postal K, Westerveld M, Wills K, Deer T. Cogn Behav Neurol. 2011 Sep;24(3):107-14.
The Brain Injury Research Program has a variety of research projects that study different populations such as high school and collegiate athletes and Emergency Department and inpatient trauma patients. These projects are occurring both locally and nationally.
Ongoing Local Projects
Association Between Post-Concussive Activity and Clinical and Neurophysiologic Recovery
Lindsay Nelson, PhD
Danny Thomas, MD, MPH; Timothy Meier, PhD; Michael Danduran, MS
Period of Performance
April 1, 2016 to March 30, 2017
High-field neuroimaging of mTBI: Investigating the neurophysiological correlates of mild traumatic brain injury using advanced neuroimaging markers in high-field, 7 Tesla scanner
Timothy Meier, PhD
Andrew Nencka, PhD; Kevin Koch, PhD
Advancing a Healthier Wisconsin Endowment and the Daniel M. Soref Charitable Trust
Period of Performance
March 2, 2016 to March 1, 2019
Ongoing National Projects
The National Sport Concussion Outcomes Study Phase 1: The Role of Equipment and Head Impact Exposure on Neurological Outcomes
Steven Broglio, PhD, ATC; JT Eckner, MD; Christopher, Giza, MD; Kevin Guskiewicz, PhD, ATC; Jeffrey Kutcher, MD; Michael McCrea, PhD
Period of Performance
July 1, 2012 to June 30, 2016
About This Project
The National Sport Concussion Outcomes Study (NSCOS) is a multi-center, prospective study designed to longitudinally investigate the short and long-term neurological consequences of sport participation. This is an observational study investigating the role that protective equipment and sub-concussive head impacts play in concussion incidence and neurological outcomes following sport related concussion (SRC). Enrollment sites were University of Michigan, University of California-Los Angeles, and University of North Carolina at Chapel Hill. The Medical College of Wisconsin was the data coordinating site.
Collegiate student-athletes of both genders were recruited to participate over 4 consecutive athletic seasons. Participants completed a standardized baseline assessment upon study entry including symptom, neurocognitive, and balance assessments. Protective equipment use and head impact profiles were monitored. Athletes who sustained a concussion during the study period, as well as matched control athletes, repeated the standardized assessment within 24 hours of injury and again within 24 hours of symptom resolution. All participants completed a similar assessment battery at the end of each competitive season.
A Prospective, Longitudinal Study of Head Impact Exposure, Neurologic Health and Brain Imaging Biomarkers in Former NCAA Athletes: 15 Year Follow-up of the Original NCAA Concussion Study
Michael McCrea, PhD; Kevin Guskiewicz, PhD, ATC
Jason Mihalik, PhD, ATC; Shi-Jiang Li, PhD; Zach Kerr, PhD, MPH
Period of Performance
July 1, 2013 to June 30, 2016
About This Project
This study is a comprehensive investigation of long-term neurologic health outcomes in former NCAA athletes. In Phase I, we will conduct a detailed health survey of former NCAA athletes who participated in the original NCAA Concussion Study and other studies by our group from 1995-2001. In Phase II, participants that completed the Phase I health survey will undergo comprehensive evaluations at the Medical College of Wisconsin and University of North Carolina at Chapel Hill, including advanced neuroimaging studies, neurocognitive and balance assessments, psychological surveys, and genetic testing. This study aims to advance the science on the chronic effects of concussion and head impact exposure, while protecting the health of athletes and the future of NCAA sports.
The NCAA-DOD Grand Alliance: Concussion Assessment, Research and Education (CARE)
Thomas McAllister, MD; Steven Broglio, PhD, ATC; Michael McCrea, PhD
Period of Performance
September 15, 2014 to September 14, 2017
About This Project
The NCAA-DoD Grand Alliance: Concussion Assessment, Research and Education (CARE) Consortium is a large-scale, multi-site study of the natural history of concussion in both sexes and multiple sports, that will address the current gaps in our knowledge, and shed light on the neurobiological mechanisms of concussion symptoms and trajectory of recovery.
The Medical College of Wisconsin leads the Advanced Research Core (ARC) of the CARE Consortium. The ARC is conducting advanced research projects that include, but are not limited to, impact sensor technologies, advanced neuroimaging, biological markers and comprehensive clinical studies to inform the neurobiopsychosocial understanding of sport related concussion (SRC).
Traumatic Brain Injury Endpoints Development (TED)
Geoffrey Manley, MD, PhD; Nancy Temkin, PhD; Stephen Wisniewski, PhD; Joseph Giacino, PhD; Sureyya Dikman, PhD; Murray Stein, MD, MPH; Harvey Levin, MD; Michael McCrea, PhD; Ramon Diaz-Arrastia, MD, PhD; Mary Vassar, RN, MS
Period of Performance
September 30, 2014 to September 29, 2019
About This Project
Better designed clinical trials leading to the first successful treatments for traumatic brain injury (TBI) are the goals of TBI Endpoints Development (TED) Initiative. With the support of an award from the Department of Defense and direct collaboration with FDA, the TED team of leading academic clinician-scientists, along with innovative industry leaders in biotechnology and imaging technology, patient advocacy organizations, and philanthropies, will examine data from thousands of athletes, soldiers and the broader population to identify and validate effective measures or “endpoints” of brain injury and recovery.
An Independent, Prospective, Head to Head Study of the Reliability and Validity of Neurocognitive Test Batteries for the Assessment of Mild Traumatic Brain Injury
Michael McCrea, PhD
Brooke Lerner, PhD; Lin Nelson, PhD
Period of Performance
March 1, 2012 to August 31, 2015
Publications From This Project
Psychometric properties and normative data for the Brief Symptom Inventory-18 (BSI-18) in high school and collegiate athletes. (Lancaster MA, McCrea MA, Nelson LD) Clin Neuropsychol 2016 Feb 29:1-13 PMID: 26924037
Prospective, Head-to-Head Study of Three Computerized Neurocognitive Assessment Tools (CNTs): Reliability and Validity for the Assessment of Sport-Related Concussion. (Nelson LD, LaRoche AA, Pfaller AY, Lerner EB, Hammeke TA, Randolph C, Barr WB, Guskiewicz K, McCrea MA) J Int Neuropsychol Soc 2016 Jan;22(1):24-37 PMID: 26714883
False-Positive Rates of Reliable Change Indices for Concussion Test Batteries: A Monte Carlo Simulation.(Nelson LD) J Athl Train 2015 Dec;50(12):1319-22 PMID: 26678291 PMCID: PMC4741259
Rates and Predictors of Invalid Baseline Test Performance in High School and Collegiate Athletes for 3 Computerized Neurocognitive Tests: ANAM, Axon Sports, and ImPACT. (Nelson LD, Pfaller AY, Rein LE, McCrea MA) Am J Sports Med 2015 Aug;43(8):2018-26 PMID: 26059178
Sport-Related Concussion Reporting and State Legislative Effects.(LaRoche AA, Nelson LD, Connelly PK, Walter KD, McCrea MA) Clin J Sport Med 2015 Apr 17: PMID 25894530
Comprehensive Study of Acute Effects and Recovery After Concussion: An Integrated Investigation of Head Impact Sensor Technology, Blood Biomarkers, Advanced Neuroimaging, Genetic Testing and Clinical Outcome Metrics
Michael McCrea, PhD
Period of Performance
September 30, 2014 to September 29, 2018
About This Project
With the goal of conducting the most comprehensive study of mTBI to date, this project capitalizes on a unique opportunity to leverage the existing infrastructure of Project Head to Head I by including additional scientific aims and technological innovations that have major significance to informing a fully neurobiopsychosocial model of concussion, including:
- Advanced, multi-modal brain neuroimaging to study changes in brain structure and function after concussion
- Blood biomarkers to study changes in brain biochemistry and physiology associated with acute concussion
- Head impact biomechanics using sensor technologies to study the kinetics and kinematics of concussion and the effects of repetitive, subconcussive head impacts
- Genetic testing to study the influence of genetics on risk of mTBI and post-concussive recovery
- Clinical measures of postconcussive symptoms and neurocognitive, balance, psychological, and other functional capacities to correlate with biological, neurophysiological, biomechanical and genetic markers of injury
A Prospective Study of Advanced MRI Biomarkers to Determine Acute Physiological Effects and Longitudinal Recovery After Sport-Related Concussion
Michael McCrea, PhD
GE NFL Head Health Challenge I
Period of Performance
April 7, 2014 to September 30, 2016
About This Project
Over the past decade, we have observed major progress in methods for clinical diagnosis and evaluation of mild traumatic brain injury (mTBI) and sport-related concussion (SRC). Critical questions remain, however, about the acute physiological effects of SRC on brain structure and function. Most concerning is that a window of cerebral vulnerability (WoCV) extends beyond the point of clinical recovery, when the brain remains physiologically-compromised and athletes are at heightened risk of repetitive injury. Unfortunately, no diagnostic or prognostic biomarker of concussion has yet been validated for clinical use. Phase I of this study leveraged our group’s existing research infrastructure by adding advanced magnetic resonance imaging (MRI) to Project Head to Head I to detect subtle changes in brain structure, function, connectivity and blood flow after SRC. In Phase I, we enrolled 27 athletes with SRC and 27 matched controls. Subjects completed MRI and clinical studies within 24 hours of injury and follow-up studies 7-10 days and 6 months post-injury.
As a natural extension of the completed Phase I effort, Phase II of this project is built around a new set of technological and scientific aims that span from advanced technical development to translational application and long-range clinical utility of multi-modal MRI biomarkers of TBI and concussion. Capitalizing on the power of advanced quantitative MRI analytics and sophisticated imaging informatics is a key cornerstone to our Phase II effort.
Publications From This Project
Cerebral Blood Flow Alterations in Acute Sport-Related Concussion. (Wang Y, Nelson LD, LaRoche AA, Pfaller AY, Nencka AS, Koch KM, McCrea M) J Neurotrauma 2015 Sep 28: PMID: 26414315
Predictive Value of Brief Personality Measures on Recovery Course and Outcome after Mild Traumatic Brain Injury (mTBI)
Lin Nelson, PhD
Terri deRoon-Cassini, PhD; Timothy Meier, PhD; Jim Hoelzle, PhD
Period of Performance
April 1, 2015 to March 30, 2017
About This Project
Although a complex set of biological, psychological, and social factors are thought to influence recovery from mild traumatic brain injury (mTBI), a rich understanding of why and how various factors influence recovery is lacking. The broad aim of this study is to evaluate the degree to which a variety of novel, brief, and cost-efficient measures improve our ability to predict the recovery trajectories of patients with mTBI. Patients with mTBI or other traumatic injuries are enrolled while admitted to the hospital, where they complete a comprehensive assessment of psychological and cognitive functioning before discharge. Using this information as well as medical, injury, and treatment information, we will identify the measure or set of measures that best predict patient outcomes within the first three months post-injury. In examining novel variables with potential to improve this prediction, we hope to better understand the risk and resilience variables with greatest relevance to recovery from traumatic injury and to identify potential targets for early interventions with this population.
Advanced MRI Applications for Mild Traumatic Brain Injury – Phase 2
Michael McCrea, PhD; Andrew Klein, MD
Period of Performance
January 1, 2016 to March 1, 2017
About This Project
This exploratory clinical trial is being conducted to aid in identifying correlations between mild traumatic brain injury (mTBI) imaging and symptoms that can help to improve advanced MRI applications for brain injury developed by the Sponsor, GE Healthcare. The Medical College of Wisconsin is one of six sites participating in this trial.