Budde Lab

Dr. Matthew Budde

The mission of our collaborative research group is to improve care and outcomes for patients with injury and diseases affecting the spinal cord. Our contribution to this goal has focused on developing and employing magnetic resonance imaging (MRI) as a tool to understand spinal cord biology and pathology. MRI is routinely used in the clinical setting for diagnosis and prognosis, and we have used its translational value to bridge the gap between preclinical animal studies and human clinical research.

We have principally focused on two techniques: diffusion and perfusion MRI. Diffusion MRI can be used to detect microscopic damage that is often invisible or difficult to interpret using conventional MRI scans. Using a variety of other experimental methods such as animal studies, histology, and computational simulations helped us develop new diffusion MRI methods to very clearly reveal microscopic damage to the spinal cord. We have recently translated these advances to studies of acute SCI trauma patients. A complementary technique, perfusion MRI, is able to measure blood flow in the spinal cord. Although cord perfusion is believed to be critical to recovery, the technologies available to detect and measure spinal cord perfusion have not been reliable and, therefore, it has not been used routinely. We developed perfusion MRI in preclinical experiments to clearly detect the extent of blood flow deficits and are also actively working to translate the same technology to patients. Collectively, we believe our research will contribute to the discovery of better treatment options available to patients and are grateful to our sources of funding: National Institutes of Health, Department of Veteran’s Affairs, Craig H. Neilsen Foundation, Department of Defense, and MCW Center for Imaging Research.

Ongoing Studies

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Noninvasive Spinal Cord Perfusion Techniques with MRI

This project seeks to develop techniques to monitor perfusion of the spinal cord noninvasively with MRI. Blood flow and perfusion of the injured spinal cord is believed to be an important feature for diagnosis and management of the acutely injured cord, but the ability to detect in patients is limited. This study will first develop and optimize MRI methods for spinal cord perfusion in a preclinical model and relate the detected features with axonal injury and neurologic outcomes. The overarching goal is to improve the care and outcomes in patients with SCI.
Funding: National Institutes of Health

Monitoring Early Acute Therapeutic Responses with MRI in Preclinical Spinal Cord Injury

The goal of this study and its value to spinal cord injury research is to establish a rigorous and clinically-relevant translational paradigm with integrated biomarkers into preclinical therapy testing. We will examine whether acute MRI markers of injury, including diffusion and perfusion MRI, are capable of detecting the effects of proven pharmacologic and surgical therapies in a preclinical model. The overarching goal is to provide clinical management teams and clinical trials with markers to gauge the efficacy of interventions.
Funding: Department of Defense

Advanced MRI of the Injured Human Spinal Cord

This project will utilize advanced MRI markers of spinal cord damage in patients with acute human spinal cord injury with the goal of predicting neurological outcome. SCI is a heterogeneous injury and our prior work in preclinical models demonstrated a specialized type of diffusion MRI that has high sensitivity to axonal injury, the pathological features most associated with neurological dysfunction. The goal of this project is to identify improved diagnostic imaging markers of spinal cord injury and outcomes to improve patient care and refine clinical trials.
Funding: Craig H. Neilsen Foundation and the Department of Veteran’s Affairs.

Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes.

(Muelbl MJ, Glaeser BL, Shah AS, Chiariello RA, Nawarawong NN, Stemper BD, Budde MD, Olsen CM.) Addict Biol. 2022 03;27(2):e13134 PMID: 35229952 PMCID: PMC8896287 SCOPUS ID: 2-s2.0-85125380733 03/02/2022
A Preclinical Rodent Model for Repetitive Subconcussive Head Impact Exposure in Contact Sport Athletes.

(Stemper BD, Shah A, Chiariello R, McCarthy C, Jessen K, Sarka B, Seifert J, Budde MD, Wang K, Olsen CM, McCrea M.) Front Behav Neurosci. 2022;16:805124 PMID: 35368301 PMCID: PMC8965565 SCOPUS ID: 2-s2.0-85127445249 04/05/2022
Stay on the Beat With Tensor-Valued Encoding: Time-Dependent Diffusion and Cell Size Estimation in ex vivo Heart

(Lasič S, Yuldasheva N, Szczepankiewicz F, Nilsson M, Budde M, Dall’Armellina E, Schneider JE, Teh I, Lundell H.) Frontiers in Physics. 25 March 2022;10 SCOPUS ID: 2-s2.0-85128351623 03/25/2022
Filtered Diffusion-Weighted MRI of the Human Cervical Spinal Cord: Feasibility and Application to Traumatic Spinal Cord Injury.

(Murphy SA, Furger R, Kurpad SN, Arpinar VE, Nencka A, Koch K, Budde MD.) AJNR Am J Neuroradiol. 2021 11;42(11):2101-2106 PMID: 34620590 PMCID: PMC8583257 SCOPUS ID: 2-s2.0-85119420507 10/09/2021
Generic acquisition protocol for quantitative MRI of the spinal cord.

(Cohen-Adad J, Alonso-Ortiz E, Abramovic M, Arneitz C, Atcheson N, Barlow L, Barry RL, Barth M, Battiston M, Büchel C, Budde M, Callot V, Combes AJE, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak A, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Wheeler-Kingshott CAMG, Germani G, Gilbert G, Giove F, Gros C, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers J, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler H, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Labounek R, Laganà MM, Laule C, Law CS, Lenglet C, Leutritz T, Liu Y, Llufriu S, Mackey S, Martinez-Heras E, Mattera L, Nestrasil I, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley G, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber KA 2nd, Weiskopf N, Wise RG, Wyss PO, Xu J.) Nat Protoc. 2021 10;16(10):4611-4632 PMID: 34400839 PMCID: PMC8811488 SCOPUS ID: 2-s2.0-85112706163 08/18/2021
Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers.

(Cohen-Adad J, Alonso-Ortiz E, Abramovic M, Arneitz C, Atcheson N, Barlow L, Barry RL, Barth M, Battiston M, Büchel C, Budde M, Callot V, Combes AJE, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak A, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Gandini Wheeler-Kingshott CAM, Germani G, Gilbert G, Giove F, Gros C, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers J, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler HH, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Labounek R, Laganà MM, Laule C, Law CS, Lenglet C, Leutritz T, Liu Y, Llufriu S, Mackey S, Martinez-Heras E, Mattera L, Nestrasil I, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley G, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber Ii KA, Weiskopf N, Wise RG, Wyss PO, Xu J.) Sci Data. 2021 08 16;8(1):219 PMID: 34400655 PMCID: PMC8368310 SCOPUS ID: 2-s2.0-85112695767 08/18/2021
Diffusion-prepared fast spin echo for artifact-free spinal cord imaging.

(Lee SY, Meyer BP, Kurpad SN, Budde MD.) Magn Reson Med. 2021 08;86(2):984-994 PMID: 33720450 PMCID: PMC8369385 SCOPUS ID: 2-s2.0-85102478269 03/16/2021
Optimized cervical spinal cord perfusion MRI after traumatic injury in the rat.

(Meyer BP, Hirschler L, Lee S, Kurpad SN, Warnking JM, Barbier EL, Budde MD.) J Cereb Blood Flow Metab. 2021 08;41(8):2010-2025 PMID: 33509036 PMCID: PMC8327111 SCOPUS ID: 2-s2.0-85100579355 01/30/2021
Diagnostic Imaging in Spinal Cord Injury.

(Shabani S, Meyer BP, Budde MD, Wang MC.) Neurosurg Clin N Am. 2021 Jul;32(3):323-331 PMID: 34053720 SCOPUS ID: 2-s2.0-85105493933 06/01/2021
Relationships between spinal cord blood flow measured with flow-sensitive alternating inversion recovery (FAIR) and neurobehavioral outcomes in rat spinal cord injury.

(Lee S, Wilkins N, Schmit BD, Kurpad SN, Budde MD.) Magn Reson Imaging. 2021 05;78:42-51 PMID: 33556483 PMCID: PMC8501290 SCOPUS ID: 2-s2.0-85100974870 02/09/2021
Association of Head Impact Exposure with White Matter Macrostructure and Microstructure Metrics.

(Brett BL, Koch KM, Muftuler LT, Budde M, McCrea MA, Meier TB.) J Neurotrauma. 2021 02 15;38(4):474-484 PMID: 33003979 PMCID: PMC7875606 SCOPUS ID: 2-s2.0-85100539318 10/03/2020
Test-retest reproducibility of in vivo oscillating gradient and microscopic anisotropy diffusion MRI in mice at 9.4 Tesla.

(Rahman N, Xu K, Omer M, Budde MD, Brown A, Baron CA.) PLoS One. 2021;16(11):e0255711 PMID: 34739479 PMCID: PMC8570471 SCOPUS ID: 2-s2.0-85118976558 11/06/2021

Neurosurgery

Budde Lab

Dr. Matthew Budde

Ongoing Studies

Recent Publications