Ophthalmology & Visual Sciences at the Eye Institute

Ongoing Study - Not Currently Enrolling

SCORE2: Comparative treatment study for macular edema secondary to Central Retinal Vein Occlusion (CRVO) 

Purpose of study:

This research study is being done to compare the safety and effectiveness of Avastin® and Eylea® in treating people with macular edema due to CRVO in the first 6 months with monthly study treatments. Avastin® and Eylea® work in a similar way, but it is not known if one is more effective than the other. During the second 6 months of the study, the safety and effectiveness of continuing monthly study treatments compared with using a regimen that uses a fewer number of study treatments will be compared in eyes that have had a good response in the first 6 months of the study. The study will also investigate whether, during the second 6 months of the study, switching to a different drug from the initial drug can help improve the vision in eyes that have not had a good response in the first 6 months of the study.

What is macular edema due to central retinal vein occlusion (CRVO)?

The retina is the thin tissue at the back of the eye that contains light-sensitive cells that allow you to see. In the center of the retina is an area called the macula, which helps you to read and see fine detail. Retinal veins drain blood away from the retina back to your heart. A blockage in one of the large retinal veins (central retinal vein occlusion - CRVO) can result in leaking of fluid and swelling in the center of the retina (macular edema).

What is involved in this study?

The study will last about 12 months with up to 14 study visits. Half of the people enrolled will receive Avastin® and half will receive Eylea® monthly for six months without knowing which one (masked study). Participants will be evaluated again at Month 6 and, depending on how they are doing, may be switched to another treatment.

 IRB Approval: PRO00022575, 8/26/14

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