Kenneth A Iczkowski, MD | Medical College of Wisconsin

Kenneth A. Iczkowski, MD

Professor

view physician profile

Locations

Pathology - Froedtert Hospital

Specialties

Pathology - Anatomic

Languages

English

Education

MD - Doctor of Medicine

Biography

Dr. lczkowski is the urologic (GU) pathologist for Froedtert Hospital/Medical College of Wisconsin; he also covers some general surgical pathology and heart biopsy specimens. He has ongoing research in prostate pathology and teaches residents and students.

Research Interests

My current research revolves around the importance of prostate cancer morphology with respect to outcome and radiologic correlations. This includes studies such as:

Refining the Gleason grading criteria (Journal of Urology, 2016; 196(4):1076-81} and proposing incorporation of the cribriform pattern of cancer into diagnostic prostate pathology (The new realization about cribriform prostate cancer. Advances in Anatomic Pathology 2018; 25:31-37.)

Correlations with molecular expression of important markers PTEN and p27 (PTEN and p27 loss}

Racial disparity in expression of pro-inflammatory markers in prostate cancer

Assisting Dr. Peter LaViolette (radiology) with histologic-radiologic correlation of prostate pathology (Predictive Cytological Topography (PiCT))

Macrophage migration inhibitory factor (MIF) gene as marker for prostate cancer; MIF gene polymorphisms which are associated with susceptibility and severity of prostate cancer. U.S. Patent No. 7,745,121.

Assisting Dr. Marja Nevalainen with prostate tissue procurement for the study of STATS and related molecules

The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma.

(van Leenders GJLH, van der Kwast TH, Grignon DJ, Evans AJ, Kristiansen G, Kweldam CF, Litjens G, McKenney JK, Melamed J, Mottet N, Paner GP, Samaratunga H, Schoots IG, Simko JP, Tsuzuki T, Varma M, Warren AY, Wheeler TM, Williamson SR, Iczkowski KA, ISUP Grading Workshop Panel Members.) Am J Surg Pathol. 2020 Aug;44(8):e87-e99 PMID: 32459716 PMCID: PMC7382533 SCOPUS ID: 2-s2.0-85085871824 05/28/2020
Identification of areas of grading difficulties in prostate cancer and comparison with artificial intelligence assisted grading.

(Egevad L, Swanberg D, Delahunt B, Ström P, Kartasalo K, Olsson H, Berney DM, Bostwick DG, Evans AJ, Humphrey PA, Iczkowski KA, Kench JG, Kristiansen G, Leite KRM, McKenney JK, Oxley J, Pan CC, Samaratunga H, Srigley JR, Takahashi H, Tsuzuki T, van der Kwast T, Varma M, Zhou M, Clements M, Eklund M.) Virchows Arch. 2020 Jun 15 PMID: 32542445 06/17/2020
Corpora amylacea in benign prostatic acini are associated with concurrent, predominantly low-grade cancer.

(Palangmonthip W, Wu R, Tarima S, Bobholz SA, LaViolette PS, Gallan AJ, Iczkowski KA.) Prostate. 2020 Jun;80(9):687-697 PMID: 32271960 SCOPUS ID: 2-s2.0-85083052266 04/10/2020
Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study.

(Ström P, Kartasalo K, Olsson H, Solorzano L, Delahunt B, Berney DM, Bostwick DG, Evans AJ, Grignon DJ, Humphrey PA, Iczkowski KA, Kench JG, Kristiansen G, van der Kwast TH, Leite KRM, McKenney JK, Oxley J, Pan CC, Samaratunga H, Srigley JR, Takahashi H, Tsuzuki T, Varma M, Zhou M, Lindberg J, Lindskog C, Ruusuvuori P, Wählby C, Grönberg H, Rantalainen M, Egevad L, Eklund M.) Lancet Oncol. 2020 02;21(2):222-232 PMID: 31926806 SCOPUS ID: 2-s2.0-85078407893 01/14/2020
Genitourinary pathology (including adrenal gland)

(Rao P, Perrino CM, Zynger DL, Jorda M, Tamboli P, Sanchez DF, Cubilla AL, Iczkowski K, Zhang M, Sircar K.) Oncological Surgical Pathology. 1 January 2020:1523-1726 SCOPUS ID: 2-s2.0-85085421476 01/01/2020
Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors.

(Udhane V, Maranto C, Hoang DT, Gu L, Erickson A, Devi S, Talati PG, Banerjee A, Iczkowski KA, Jacobsohn K, See WA, Mirtti T, Kilari D, Nevalainen MT.) Mol Cancer Ther. 2020 01;19(1):231-246 PMID: 31548294 PMCID: PMC6946850 SCOPUS ID: 2-s2.0-85077669370 09/25/2019
Small Cell Variant of Metastatic Melanoma: A Mimicker of Lymphoblastic Leukemia/Lymphoma.

(Ronen S, Czaja RC, Ronen N, Pantazis CG, Iczkowski KA.) Dermatopathology (Basel). 2019 Oct-Dec;6(4):231-236 PMID: 31966987 PMCID: PMC6940452 01/23/2020
Eosinophilic Kidney Tumors: Old and New.

(Iczkowski KA, Czaja RC.) Arch Pathol Lab Med. 2019 12;143(12):1455-1463 PMID: 31403331 SCOPUS ID: 2-s2.0-85075812682 08/14/2019
MYB-NFIB gene fusion in prostatic basal cell carcinoma: clinicopathologic correlates and comparison with basal cell adenoma and florid basal cell hyperplasia.

(Magers MJ, Iczkowski KA, Montironi R, Grignon DJ, Zhang S, Williamson SR, Yang X, Wang M, Osunkoya AO, Lopez-Beltran A, Hes O, Eble JN, Cheng L.) Mod Pathol. 2019 11;32(11):1666-1674 PMID: 31189999 SCOPUS ID: 2-s2.0-85066978883 06/14/2019
Improving sensitivity of amyloid detection by Congo red stain by using polarizing microscope and avoiding pitfalls.

(El-Meanawy A, Mueller C, Iczkowski KA.) Diagn Pathol. 2019 Jun 14;14(1):57 PMID: 31200733 PMCID: PMC6567537 SCOPUS ID: 2-s2.0-85067289424 06/16/2019
KIF3B protein expression loss correlates with metastatic ability of prostate cancer.

(Kravtsov O, Hartley CP, Compérat EM, Iczkowski KA.) Am J Clin Exp Urol. 2019;7(3):178-181 PMID: 31317057 PMCID: PMC6627541 07/19/2019
Classification before segmentation: Improved u-net prostate segmentation

(Nowling RJ, Bukowy J, McGarry SD, Nencka AS, Blasko O, Urbain J, Lowman A, Barrington A, Banerjee A, Iczkowski KA, Laviolette PS.) 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings. May 2019 SCOPUS ID: 2-s2.0-85073032385 05/01/2019