Pathology & Laboratory Medicine

Publications

• NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers.

  (Sun Y, Yang N, Utama FE, Udhane SS, Zhang J, Peck AR, Yanac A, Duffey K, Langenheim JF, Udhane V, Xia G, Peterson JF, Jorns JM, Nevalainen MT, Rouet R, Schofield P, Christ D, Ormandy CJ, Rosenberg AL, Chervoneva I, Tsaih SW, Flister MJ, Fuchs SY, Wagner KU, Rui H.) Sci Adv. 2021 Sep 17;7(38):eabc8145 PMID: 34524841 PMCID: PMC8443188 SCOPUS ID: 2-s2.0-85115168052 09/16/2021

• Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness.

  (Felix JC, Sheinin YM, Suster D, Ronen N, Ratiani M, Vanden Heuvel T, Winge E, Patton MD, Rau MJ, Ge L, Sun Y, Udhane SS, Langenheim JF, Rui H.) Ann Diagn Pathol. 2021 Aug;53:151744 PMID: 33991784 PMCID: PMC8053602 SCOPUS ID: 2-s2.0-85105597450 05/16/2021

• Sensitive and Specific Immunohistochemistry Protocol for Nucleocapsid Protein from All Common SARS-CoV-2 Virus Strains in Formalin-Fixed, Paraffin Embedded Tissues.

  (Sun Y, Ge L, Udhane SS, Langenheim JF, Rau MJ, Patton MD, Gallan AJ, Felix JC, Rui H.) Methods Protoc. 2021 Jul 10;4(3) PMID: 34287344 PMCID: PMC8293419 SCOPUS ID: 2-s2.0-85111011758 07/22/2021

• Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling.

  (Tran TH, Utama FE, Sato T, Peck AR, Langenheim JF, Udhane SS, Sun Y, Liu C, Girondo MA, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Palazzo JP, Bibbo M, Auer PW, Flister MJ, Hyslop T, Mitchell EP, Chervoneva I, Rui H.) Clin Cancer Res. 2018 12 15;24(24):6355-6366 PMID: 30097435 SCOPUS ID: 2-s2.0-85058487046 08/12/2018

• GHR/PRLR Heteromultimer Is Composed of GHR Homodimers and PRLR Homodimers.

  (Liu Y, Zhang Y, Jiang J, Lobie PE, Paulmurugan R, Langenheim JF, Chen WY, Zinn KR, Frank SJ.) Mol Endocrinol. 2016 May;30(5):504-17 PMID: 27003442 PMCID: PMC4853563 SCOPUS ID: 2-s2.0-84964876556 03/24/2016

• Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis.

  (Kim BG, Yoo JY, Kim TH, Shin JH, Langenheim JF, Ferguson SD, Fazleabas AT, Young SL, Lessey BA, Jeong JW.) Hum Reprod. 2015 May;30(5):1069-78 PMID: 25750101 PMCID: PMC4400199 SCOPUS ID: 2-s2.0-84929716718 03/10/2015

• Dynamic analysis of GH receptor conformational changes by split luciferase complementation.

  (Liu Y, Berry PA, Zhang Y, Jiang J, Lobie PE, Paulmurugan R, Langenheim JF, Chen WY, Zinn KR, Frank SJ.) Mol Endocrinol. 2014 Nov;28(11):1807-19 PMID: 25188449 PMCID: PMC4213363 SCOPUS ID: 2-s2.0-84908349618 09/05/2014

• The role of prolactin receptor in GH signaling in breast cancer cells.

  (Xu J, Sun D, Jiang J, Deng L, Zhang Y, Yu H, Bahl D, Langenheim JF, Chen WY, Fuchs SY, Frank SJ.) Mol Endocrinol. 2013 Feb;27(2):266-79 PMID: 23192981 PMCID: PMC3683809 SCOPUS ID: 2-s2.0-84873032331 11/30/2012

• Stromal-epithelial interactions modulate cross-talk between prolactin receptor and HER2/Neu in breast cancer.

  (Xu C, Langenheim JF, Chen WY.) Breast Cancer Res Treat. 2012 Jul;134(1):157-69 PMID: 22270933 SCOPUS ID: 2-s2.0-84863920205 01/25/2012

• Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex.

  (Xu J, Zhang Y, Berry PA, Jiang J, Lobie PE, Langenheim JF, Chen WY, Frank SJ.) Mol Endocrinol. 2011 Apr;25(4):597-610 PMID: 21310852 PMCID: PMC3063080 SCOPUS ID: 2-s2.0-79953754929 02/12/2011

• Improving the pharmacokinetics/pharmacodynamics of prolactin, GH, and their antagonists by fusion to a synthetic albumin-binding peptide.

  (Langenheim JF, Chen WY.) J Endocrinol. 2009 Dec;203(3):375-87 PMID: 19770179 SCOPUS ID: 2-s2.0-71949120963 09/23/2009

• Development of a novel ligand that activates JAK2/STAT5 signaling through a heterodimer of prolactin receptor and growth hormone receptor.

  (Langenheim JF, Chen WY.) J Recept Signal Transduct Res. 2009;29(2):107-12 PMID: 19519175 SCOPUS ID: 2-s2.0-68949175303 06/13/2009