Ravi K. Singh, PhD

Publications

• SRSF2 Regulation of MDM2 Reveals Splicing as a Therapeutic Vulnerability of the p53 Pathway.

  (Comiskey DF Jr, Montes M, Khurshid S, Singh RK, Chandler DS.) Mol Cancer Res. 2020 Feb;18(2):194-203 PMID: 31662450 10/31/2019

• Leukemic presentation of ALK-positive anaplastic large cell lymphoma with a novel partner, poly(A) binding protein cytoplasmic 1 (PABPC1), responding to single-agent crizotinib.

  (Graetz D, Crews KR, Azzato EM, Singh RK, Raimondi S, Mason J, Valentine M, Mullighan CG, Holland A, Inaba H, Leventaki V.) Haematologica. 2019 May;104(5):e218-e221 PMID: 30819904 PMCID: PMC6518893 SCOPUS ID: 2-s2.0-85065466454 03/02/2019

• Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.

  (Singh RK, Kolonin AM, Fiorotto ML, Cooper TA.) Cell Rep. 2018 Jul 03;24(1):197-208 PMID: 29972780 PMCID: PMC6070147 07/05/2018

• Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage.

  (Comiskey DF Jr, Jacob AG, Singh RK, Tapia-Santos AS, Chandler DS.) Nucleic Acids Res. 2015 Apr 30;43(8):4202-18 PMID: 25845590 PMCID: PMC4417157 04/08/2015

• The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function.

  (Pedrotti S, Giudice J, Dagnino-Acosta A, Knoblauch M, Singh RK, Hanna A, Mo Q, Hicks J, Hamilton S, Cooper TA.) Hum Mol Genet. 2015 Apr 15;24(8):2360-74 PMID: 25575511 PMCID: PMC4380076 01/13/2015

• Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.

  (Gennarino VA, Singh RK, White JJ, De Maio A, Han K, Kim JY, Jafar-Nejad P, di Ronza A, Kang H, Sayegh LS, Cooper TA, Orr HT, Sillitoe RV, Zoghbi HY.) Cell. 2015 Mar 12;160(6):1087-98 PMID: 25768905 PMCID: PMC4383046 03/15/2015

• Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis.

  (Singh RK, Xia Z, Bland CS, Kalsotra A, Scavuzzo MA, Curk T, Ule J, Li W, Cooper TA.) Mol Cell. 2014 Aug 21;55(4):592-603 PMID: 25087874 PMCID: PMC4142074 08/05/2014

• The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA.

  (Jacob AG, Singh RK, Mohammad F, Bebee TW, Chandler DS.) J Biol Chem. 2014 Jun 20;289(25):17350-64 PMID: 24798327 PMCID: PMC4067169 05/07/2014

• The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression.

  (Kalsotra A, Singh RK, Gurha P, Ward AJ, Creighton CJ, Cooper TA.) Cell Rep. 2014 Jan 30;6(2):336-45 PMID: 24412363 PMCID: PMC3927417 01/15/2014

• Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways.

  (Jacob AG, Singh RK, Comiskey DF Jr, Rouhier MF, Mohammad F, Bebee TW, Chandler DS.) PLoS One. 2014;9(8):e104444 PMID: 25105592 PMCID: PMC4126728 08/12/2014

• Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma.

  (Jacob AG, O'Brien D, Singh RK, Comiskey DF Jr, Littleton RM, Mohammad F, Gladman JT, Widmann MC, Jeyaraj SC, Bolinger C, Anderson JR, Barkauskas DA, Boris-Lawrie K, Chandler DS.) Neoplasia. 2013 Sep;15(9):1049-63 PMID: 24027430 PMCID: PMC3769884 09/13/2013

• Pre-mRNA splicing in disease and therapeutics.

  (Singh RK, Cooper TA.) Trends Mol Med. 2012 Aug;18(8):472-82 PMID: 22819011 PMCID: PMC3411911 07/24/2012