Michael J. Thomas, PhD

Professor

Locations

Pharmacology and Toxicology

Contact Information

General Interests

Lipidomic Analysis of Lipoproteins

Education

Post doctoral Research Associate, Louisiana State University, 1978
Postdoctoral Research Associate, Michigan State University, 1976
PhD, Chemistry, University of California-Los Angeles, 1973
BS, Chemistry, Indiana University, 1969

Honors and Awards

Chemistry with Honors, Indiana University - 1969

Research Interests

Two areas of specialized interest are improving lipidomic analysis of lipoproteins and determining the three-dimensional structure apolipoprotein A-I in lipoproteins. We have developed chemical cross-linking methods employed with mass spectrometry to assess the conformation of apolipoprotein A-I in both the lipid-free and lipid bound forms. I am also interested in the application of mass spectrometry to biomedical and biochemical studies. We are constantly working to implement simple mass spectrometric procedures for performing experiments and quantifying the results.

A Pilot Clinical Study to Investigate the Hypomethylating Properties of Freeze-dried Black Raspberries in Patients with Myelodysplastic Syndrome or Myeloproliferative Neoplasm.

(Dong A, Pan X, Lin CW, Huang YW, Krause H, Pan P, Baim A, Thomas MJ, Chen X, Yu J, Michaelis L, Liu P, Wang LS, Atallah E.) J Cancer Prev. 2022 Jun 30;27(2):129-138 PMID: 35864858 PMCID: PMC9271408 07/23/2022
Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.

(Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG.) Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2708-2725 PMID: 34551590 PMCID: PMC8551036 SCOPUS ID: 2-s2.0-85118592107 09/24/2021
Linking Lipid-Related Transcription and Cardiovascular Disease Through GWAS.

(Thomas MJ, Sorci-Thomas MG.) Circ Res. 2020 Nov 06;127(11):1362-1364 PMID: 33151796 PMCID: PMC7653958 SCOPUS ID: 2-s2.0-85095758046 11/06/2020
The ins and outs of lipid rafts: functions in intracellular cholesterol homeostasis, microparticles, and cell membranes: Thematic Review Series: Biology of Lipid Rafts.

(Ouweneel AB, Thomas MJ, Sorci-Thomas MG.) J Lipid Res. 2020 May;61(5):676-686 PMID: 33715815 PMCID: PMC7193959 SCOPUS ID: 2-s2.0-85084961109 03/16/2021
The ins and outs of lipid rafts: functions in intracellular cholesterol homeostasis, microparticles, and cell membranes.

(Ouweneel AB, Thomas MJ, Sorci-Thomas MG.) J Lipid Res. 2020 05;61(5):676-686 PMID: 31888980 PMCID: PMC7193959 SCOPUS ID: 2-s2.0-85084961109 01/01/2020
Recombinant LCAT (Lecithin:Cholesterol Acyltransferase) Rescues Defective HDL (High-Density Lipoprotein)-Mediated Endothelial Protection in Acute Coronary Syndrome.

(Ossoli A, Simonelli S, Varrenti M, Morici N, Oliva F, Stucchi M, Gomaraschi M, Strazzella A, Arnaboldi L, Thomas MJ, Sorci-Thomas MG, Corsini A, Veglia F, Franceschini G, Karathanasis SK, Calabresi L.) Arterioscler Thromb Vasc Biol. 2019 May;39(5):915-924 PMID: 30894011 SCOPUS ID: 2-s2.0-85065216772 03/22/2019
Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis.

(Huang LH, Zinselmeyer BH, Chang CH, Saunders BT, Elvington A, Baba O, Broekelmann TJ, Qi L, Rueve JS, Swartz MA, Kim BS, Mecham RP, Wiig H, Thomas MJ, Sorci-Thomas MG, Randolph GJ.) Cell Metab. 2019 Feb 05;29(2):475-487.e7 PMID: 30415924 PMCID: PMC6365189 SCOPUS ID: 2-s2.0-85060717940 11/13/2018
High-Density Lipoprotein Functionality as a New Pharmacological Target on Cardiovascular Disease: Unifying Mechanism That Explains High-Density Lipoprotein Protection Toward the Progression of Atherosclerosis.

(Favari E, Thomas MJ, Sorci-Thomas MG.) J Cardiovasc Pharmacol. 2018 Jun;71(6):325-331 PMID: 29528874 SCOPUS ID: 2-s2.0-85051788295 03/13/2018
Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages.

(Kriska T, Thomas MJ, Falck JR, Campbell WB.) J Lipid Res. 2018 Apr;59(4):615-624 PMID: 29472381 PMCID: PMC5880500 SCOPUS ID: 2-s2.0-85045010822 02/24/2018
Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.

(Gaddis DE, Padgett LE, Wu R, McSkimming C, Romines V, Taylor AM, McNamara CA, Kronenberg M, Crotty S, Thomas MJ, Sorci-Thomas MG, Hedrick CC.) Nat Commun. 2018 Mar 15;9(1):1095 PMID: 29545616 PMCID: PMC5854619 SCOPUS ID: 2-s2.0-85044288848 03/17/2018
A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state.

(Melchior JT, Walker RG, Cooke AL, Morris J, Castleberry M, Thompson TB, Jones MK, Song HD, Rye KA, Oda MN, Sorci-Thomas MG, Thomas MJ, Heinecke JW, Mei X, Atkinson D, Segrest JP, Lund-Katz S, Phillips MC, Davidson WS.) Nat Struct Mol Biol. 2017 Dec;24(12):1093-1099 PMID: 29131142 PMCID: PMC5749415 SCOPUS ID: 2-s2.0-85039561595 11/14/2017
Anti-inflammatory liaisons: T regulatory cells and HDL.

(Sorci-Thomas MG, Thomas MJ.) J Lipid Res. 2017 Aug;58(8):1491-1492 PMID: 28630261 PMCID: PMC5538272 SCOPUS ID: 2-s2.0-85026671098 06/21/2017