Ming You, MD, PhD

Associate Provost for Cancer Research, Founding Director of Disease Prevention Research Center, Joseph F. Heil Jr. Professor in Molecular Oncogenesis

Contact Information

Education

PhD, Medical College of Ohio, 1989
BS/MD, Peking University School of Medicine, 1982

Biography

Ming You, MD, PhD, joined the faculty at the Medical College of Wisconsin in the Department of Pharmacology and Toxicology in September 2010. He is currently the principal investigator or the co-principal investigator for multiple NIH grants that are focused on genetics and chemoprevention of lung cancer. Some ongoing projects in the You laboratory are the identification of candidate lung cancer susceptibility genes by capture-sequencing of targeted regions or genes, identification of frequent somatic mutations in lung adenocarcinomas and squamous cell carcinomas by exome sequencing, and identification of those somatic mutations predictive of clinical outcome of stage I NSCLC by SNP genotyping.

Dr. You is a member of the Board of Scientific Counselors of the National Cancer Institute. He is a current member and past chair of the Chemo/Dietary Prevention Study Section (CDP) and a member of the Chemical Pathology Study Section (CPA) at the National Institutes of Health. Dr. You also served as a member of the NCI’s Cancer Susceptibility Think Tank and Cancer Chemoprevention Think Tank and the chair of the Review Panel for Chemopreventive Agent Development Research Group (CADRG), Division of Cancer Prevention at the National Cancer Institute. He is an Associate Editor of Cancer Research and Cancer Prevention Research and is on the editorial board of PLoS One and Carcinogenesis.

He has lectured broadly and internationally in his areas of interest and expertise. His publications have focused on work in genetics and chemoprevention of lung cancer and his bibliography includes over 170 titles. He has mentored a large number of graduate students and postdoctoral fellows and has a large laboratory, including a number of research and tenure track faculty members.

Research Experience

Carcinoma, Non-Small-Cell Lung
Carcinoma, Small Cell
Chemoprevention
DNA Fingerprinting
Genes, Neoplasm
Molecular Biology
Tumor Suppressor Protein p53

Research Interests

Lung Cancer Chemoprevention

Susceptibility Genes for Rodent and Human Lung Cancer

Molecular Pathogenesis of Lung Cancer

Mitochondria as a Novel Target for Cancer Chemoprevention: Emergence of Mitochondrial Targeting Agents.

(Huang M, Myers CR, Wang Y, You M.) Cancer Prev Res (Phila). 2020 Dec 10 PMID: 33303695 12/12/2020
Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade.

(Hu W, Wang G, Wang Y, Riese MJ, You M.) iScience. 2020 Oct 23;23(10):101580 PMID: 33083746 PMCID: PMC7554032 10/22/2020
A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response.

(Xiong D, Wang Y, You M.) Nat Commun. 2020 10 08;11(1):5084 PMID: 33033253 PMCID: PMC7545100 SCOPUS ID: 2-s2.0-85092272013 10/10/2020
Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma.

(Bui D, Li L, Yin T, Wang X, Gao S, You M, Singh R, Hu M.) J Agric Food Chem. 2020 Jun 17;68(24):6576-6587 PMID: 32348135 PMCID: PMC7604171 SCOPUS ID: 2-s2.0-85086625598 04/30/2020
Anticancer effect of physical activity is mediated by modulation of extracellular microRNA in blood.

(Pulliero A, You M, Chaluvally-Raghavan P, Marengo B, Domenicotti C, Banelli B, Degan P, Molfetta L, Gianiorio F, Izzotti A.) Oncotarget. 2020 Jun 02;11(22):2106-2119 PMID: 32547708 PMCID: PMC7275780 06/18/2020
Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I.

(Zhang Q, Cheng G, Pan J, Zielonka J, Xiong D, Myers CR, Feng L, Shin SS, Kim YH, Bui D, Hu M, Bennett B, Schmainda K, Wang Y, Kalyanaraman B, You M.) Cell Commun Signal. 2020 04 07;18(1):58 PMID: 32264893 PMCID: PMC7140380 SCOPUS ID: 2-s2.0-85083071315 04/09/2020
Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses.

(Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B.) Free Radic Biol Med. 2020 02 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019
Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p, and 4q.

(Musolf AM, Moiz BA, Sun H, Pikielny CW, Bossé Y, Mandal D, de Andrade M, Gaba C, Yang P, Li Y, You M, Govindan R, Wilson RK, Kupert EY, Anderson MW, Schwartz AG, Pinney SM, Amos CI, Bailey-Wilson JE.) Cancer Epidemiol Biomarkers Prev. 2020 02;29(2):434-442 PMID: 31826912 PMCID: PMC7007362 SCOPUS ID: 2-s2.0-85079076161 12/13/2019
miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer.

(Parashar D, Geethadevi A, Aure MR, Mishra J, George J, Chen C, Mishra MK, Tahiri A, Zhao W, Nair B, Lu Y, Mangala LS, Rodriguez-Aguayo C, Lopez-Berestein G, Camara AKS, Liang M, Rader JS, Ramchandran R, You M, Sood AK, Kristensen VN, Mills GB, Pradeep S, Chaluvally-Raghavan P.) Cell Rep. 2019 12 24;29(13):4389-4406.e10 PMID: 31875548 PMCID: PMC7380555 SCOPUS ID: 2-s2.0-85076674271 12/26/2019
Potentiation of Kras peptide cancer vaccine by avasimibe, a cholesterol modulator.

(Pan J, Zhang Q, Palen K, Wang L, Qiao L, Johnson B, Sei S, Shoemaker RH, Lubet RA, Wang Y, You M.) EBioMedicine. 2019 Nov;49:72-81 PMID: 31680003 PMCID: PMC6945201 SCOPUS ID: 2-s2.0-85074132937 11/05/2019
Tumor intrinsic immunity related proteins may be novel tumor suppressors in some types of cancer.

(Xiong D, Wang Y, You M.) Sci Rep. 2019 07 29;9(1):10918 PMID: 31358815 PMCID: PMC6662687 SCOPUS ID: 2-s2.0-85069918844 07/31/2019
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.

(Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M.) Nat Commun. 2019 05 17;10(1):2205 PMID: 31101821 PMCID: PMC6525201 SCOPUS ID: 2-s2.0-85065824371 05/19/2019

Pharmacology and Toxicology