Clinton Piper, PhD
Matched at University of Pittsburgh Medical Center; Specialty: Pediatrics
Faculty Advisor
- William Drobyski, MD, Medicine, Pediatrics, and Microbiology & Immunology
Locations
- Medical Scientist Training Program
Contact Information
Education
BS, Biochemistry, University of Michigan, 2014
Research Interests
The proinflammatory mechanisms of donor-CD4 T cell-derived GM-CSF in gastrointestinal acute GVHD.
Research Experience
Medical College of Wisconsin, 2016-2020
Advisor:William Drobyski, MD
Project:The role of donor T cell-derived GM-CSF in the pathogenesis of gastrointestinal acute GVHD (F30HL143870)
Rush University, 2012-2013
Advisor: Jeffrey Borgia, PhD
Project: Development of a serum autoantibody biomarker panel to predict response to treatment and prognosis in stage IV non-small cell lung cancer patients.
University of Michigan, 2011-2013
Advisors: David Shultis, PhD and Yang Zhang, PhD
Project: Expression, purification, and biophysical characterization of computationally designed proteins.
Publications
Piper C, Zhou V, Komorowski R, et al. Pathogenic Bhlhe40+ GM-CSF+ CD4+ T cells promote indirect alloantigen presentation in the GI tract during GVHD. Blood. 2020;135(8):568-581. doi:10.1182/blood.2019001696. PMID: 31880771.
Piper C, Drobyski WR. Inflammatory Cytokine Networks in Gastrointestinal Tract Graft vs. Host Disease. Front Immunol. 2019;10:163. Published 2019 Feb 22. doi:10.3389/fimmu.2019.00163. PMID: 30853956.
Shultis D, Mitra P, Huang X, et al. Changing the Apoptosis Pathway through Evolutionary Protein Design. J Mol Biol. 2019;431(4):825-841. doi:10.1016/j.jmb.2018.12.016. PMID: 30625288
Agle K, Vincent BG, Piper C, et al. Bim regulates the survival and suppressive capability of CD8+ FOXP3+ regulatory T cells during murine GVHD. Blood. 2018;132(4):435-447. doi:10.1182/blood-2017-09-807156. PMID: 29769260.
Roy, Ishan, Donna M. McAllister, Egal Gorse, Kate Dixon, Clinton T. Piper, Noah P. Zimmerman, Anthony E. Getschman, et al. 2015. "Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling." Cancer Research 75 (17): 3529–42. PMID: 26330165
Meeting Abstracts
Piper C, Khatun A, Chen Y, Zander R, Cui W, & Drobyski WR. Single Cell Immune Profiling of Colitogenic T Cells during Acute Graft Versus Host Disease Reveals Two Novel Transcriptionally Distinct CD4+ GM-CSF+ Lineages [Conference presentation]. ASH 2019 Annual Meeting. Orlando, FL.
Piper C, Zhou V, Edelson BT, Taneja R, & Drobyski WR. A Bhlhe40/GM-CSF Axis Potentiates Gastrointestinal Tract Inflammation during Acute Graft Versus Host Disease [Conference presentation]. ASH 2018 Annual Meeting. San Diego, CA.
General Interests
Running, traveling, language learning