Research Collaborate Lab Bench

Medical Scientist Training Program

Paytsar Topchyan

Paytsar Topchyan

G3 Student

Faculty Advisor

  • Weiguo Cui, PhD, Microbiology & Immunology

Locations

  • Medical Scientist Training Program

Contact Information

Education

MS, Oral Biology, University of California-Los Angeles, 2016
BS, Biology, University of California-Los Angeles, 2014

Research Interests

Cancer Immunology

Research Experiences

Medical College of Wisconsin, 2018-present
Advisor: Weiguo Cui, PhD
Project: Reprogramming tumor reactive CD8 T cells by targeting the IL-21-BATF pathway to treat melanoma (F30CA246920)

University of California-Los Angeles, 2012-2016
Advisor: Dr. Anahid Jewett, PhD, MPH

Publications

Xin G, Khatun A, Topchyan P, et al. Pathogen-Boosted Adoptive Cell Transfer Therapy Induces Endogenous Antitumor Immunity through Antigen Spreading. Cancer Immunol Res. 2020;8(1):7-18. doi:10.1158/2326-6066.CIR-19-0251

Kaur K, Kozlowska AK, Topchyan P, et al. Probiotic-Treated Super-Charged NK Cells Efficiently Clear Poorly Differentiated Pancreatic Tumors in Hu-BLT Mice. Cancers (Basel). 2019;12(1):63. Published 2019 Dec 24. doi:10.3390/cancers12010063

Kaur K, Chang HH, Topchyan P, et al. Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice. Front Immunol. 2018;9:1229. Published 2018 Jun 21. doi:10.3389/fimmu.2018.01229

Kaur K, Topchyan P, Kozlowska AK, et al. Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs. Oncoimmunology. 2018;7(5):e1426518. Published 2018 Feb 22. doi:10.1080/2162402X.2018.1426518

Kozlowska, A. K., Topchyan, P., Kaur, K., Tseng, H.-C., Teruel, A., Hiraga, T., & Jewett, A. (2017). Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs. Journal of Cancer, 8(4), 537–554. http://doi.org/10.7150/jca.15989

Kaur, K., Cook, J., Park, S.-H., Topchyan, P., Kozlowska, A., Ohanian, N., … Jewett, A. (2017). Novel Strategy to Expand Super-Charged NK Cells with Significant Potential to Lyse and Differentiate Cancer Stem Cells: Differences in NK Expansion and Function between Healthy and Cancer Patients. Frontiers in Immunology, 8, 297. http://doi.org/10.3389/fimmu.2017.00297

Kozlowska, A. K., Kaur, K., Topchyan, P., & Jewett, A. (2017). Novel strategies to target cancer stem cells by NK cells; studies in humanized mice. Frontiers in bioscience (Landmark edition), 22, 370-384. http://dx.doi.org/10.2741/4489

Kozlowska, A. K., Kaur, K., Topchyan, P., & Jewett, A. (2016). Adoptive transfer of osteoclast-expanded Natural Killer cells for immunotherapy targeting cancer stem-like cells in humanized mice. Cancer Immunology, Immunotherapy : CII, 65(7), 835–845. http://doi.org/10.1007/s00262-016-1822-9

Kozlowska, A. K., Tseng, H. C., Kaur, K., Topchyan, P., Inagaki, A., Bui, V. T., ... & Jewett, A. (2016). Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells. Cancer Immunology, Immunotherapy, 65(9), 1085-1097. 10.1007/s00262-016-1866-x

Tseng, H.-C., Arasteh, A., Kaur, K., Kozlowska, A., Topchyan, P., & Jewett, A. (2015). Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice. Frontiers in Immunology, 6, 259. http://doi.org/10.3389/fimmu.2015.00259

Bui, V. T., Tseng, H.-C., Kozlowska, A., Maung, P. O., Kaur, K., Topchyan, P., & Jewett, A. (2015). Augmented IFN-γ and TNF-α Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release; Regulation by IL-10. Frontiers in Immunology, 6, 576. http://doi.org/10.3389/fimmu.2015.00576

Meeting Abstracts

P. Topchyan, K. Kaur, A. Kozlowska, H. Tseng-Dick, A. Jewett. Super NKs prevent tumor CSC growth in BLT humanized mice. 2016 AADR/CADR Annual Meeting & Exhibition. Los Angeles, CA.

General Interests

Reading, cooking, and traveling