- Weiguo Cui, PhD, Microbiology & Immunology
- Medical Scientist Training Program
BS, Biology, University of California-Los Angeles, 2014
Medical College of Wisconsin, 2018-present
Advisor: Weiguo Cui, PhD
Project: Reprogramming tumor reactive CD8 T cells by targeting the IL-21-BATF pathway to treat melanoma (F30CA246920)
University of California-Los Angeles, 2012-2016
Advisor: Dr. Anahid Jewett, PhD, MPH
Chen Y, Shen J, Kasmani MY, Topchyan P, Cui W. Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8+ T Cells. Cells. 2021 Aug 20;10(8):2143. doi: 10.3390/cells10082143. PMID: 34440912; PMCID: PMC8392357.
Cheng G, Hardy M, Topchyan P, et al. Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects. iScience. 2021 May 31;24(6):102673. doi: 10.1016/j.isci.2021.102673. PMID: 34189437; PMCID: PMC8215227.
Zhu W, Zheng Y, Yu M, Wei J, Zhang Y, Topchyan P, et al. SARS-CoV-2 receptor binding domain-specific antibodies activate platelets with features resembling the pathogenic antibodies in heparin-induced thrombocytopenia. Res Sq [Preprint]. 2021 Apr 26:rs.3.rs-462080. doi: 10.21203/rs.3.rs-462080/v1. PMID: 34013243; PMCID: PMC8132233.
Topchyan P, Xin G, Chen Y,et al. Harnessing the IL-21-BATF Pathway in the CD8+ T Cell Anti-Tumor Response. Cancers (Basel). 2021 Mar 12;13(6):1263. doi: 10.3390/cancers13061263. PMID: 33809259; PMCID: PMC7998696.
Xin G, Chen Y, Topchyan P, et al. Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer. Cancer Immunol Res. 2021 Feb 12:canimm.0433.2020. doi: 10.1158/2326-6066.CIR-20-0433. Epub ahead of print. PMID: 33579728.
Cheng G, Hardy M, Topchyan P, et al. Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone. Sci Rep. 2020 Oct 21;10(1):17872. doi: 10.1038/s41598-020-74808-0. PMID: 33087770; PMCID: PMC7578061.
Xin G, Khatun A, Topchyan P, et al. Pathogen-Boosted Adoptive Cell Transfer Therapy Induces Endogenous Antitumor Immunity through Antigen Spreading. Cancer Immunol Res. 2020;8(1):7-18. doi:10.1158/2326-6066.CIR-19-0251
Kaur K, Kozlowska AK, Topchyan P, et al. Probiotic-Treated Super-Charged NK Cells Efficiently Clear Poorly Differentiated Pancreatic Tumors in Hu-BLT Mice. Cancers (Basel). 2019;12(1):63. Published 2019 Dec 24. doi:10.3390/cancers12010063
Kaur K, Chang HH, Topchyan P, et al. Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice. Front Immunol. 2018;9:1229. Published 2018 Jun 21. doi:10.3389/fimmu.2018.01229
Kaur K, Topchyan P, Kozlowska AK, et al. Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs. Oncoimmunology. 2018;7(5):e1426518. Published 2018 Feb 22. doi:10.1080/2162402X.2018.1426518
Kozlowska, A. K., Topchyan, P., Kaur, K., Tseng, H.-C., Teruel, A., Hiraga, T., & Jewett, A. (2017). Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs. Journal of Cancer, 8(4), 537–554. http://doi.org/10.7150/jca.15989
Kaur, K., Cook, J., Park, S.-H., Topchyan, P., Kozlowska, A., Ohanian, N., … Jewett, A. (2017). Novel Strategy to Expand Super-Charged NK Cells with Significant Potential to Lyse and Differentiate Cancer Stem Cells: Differences in NK Expansion and Function between Healthy and Cancer Patients. Frontiers in Immunology, 8, 297. http://doi.org/10.3389/fimmu.2017.00297
Kozlowska, A. K., Kaur, K., Topchyan, P., & Jewett, A. (2017). Novel strategies to target cancer stem cells by NK cells; studies in humanized mice. Frontiers in bioscience (Landmark edition), 22, 370-384. http://dx.doi.org/10.2741/4489
Kozlowska, A. K., Kaur, K., Topchyan, P., & Jewett, A. (2016). Adoptive transfer of osteoclast-expanded Natural Killer cells for immunotherapy targeting cancer stem-like cells in humanized mice. Cancer Immunology, Immunotherapy : CII, 65(7), 835–845. http://doi.org/10.1007/s00262-016-1822-9
Kozlowska, A. K., Tseng, H. C., Kaur, K., Topchyan, P., Inagaki, A., Bui, V. T., ... & Jewett, A. (2016). Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells. Cancer Immunology, Immunotherapy, 65(9), 1085-1097. 10.1007/s00262-016-1866-x
Tseng, H.-C., Arasteh, A., Kaur, K., Kozlowska, A., Topchyan, P., & Jewett, A. (2015). Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice. Frontiers in Immunology, 6, 259. http://doi.org/10.3389/fimmu.2015.00259
Bui, V. T., Tseng, H.-C., Kozlowska, A., Maung, P. O., Kaur, K., Topchyan, P., & Jewett, A. (2015). Augmented IFN-γ and TNF-α Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release; Regulation by IL-10. Frontiers in Immunology, 6, 576. http://doi.org/10.3389/fimmu.2015.00576
P. Topchyan, K. Kaur, A. Kozlowska, H. Tseng-Dick, A. Jewett. Super NKs prevent tumor CSC growth in BLT humanized mice. 2016 AADR/CADR Annual Meeting & Exhibition. Los Angeles, CA.
Reading, cooking, and traveling