Biostatistics Research Seminar
Adaptive Multi-arm Multi-stage Group Sequential Designs
Cyrus Mehta, PhD
Professor, Harvard T.H. Chan, School of Public Health
President and Co-founder, Cytel, Inc. Cambridge, MA.
Abstract: Multi-arm Multi-stage (MAMS) Group Sequential designs are generalizations of Two-arm Multi-stage Group Sequential designs for comparing more than one treatment arm to a common control arm with possible early stopping for efficacy or futility. Adaptive MAMS group sequential designs permit, in addition to early stopping, treatment selection and sample size re-estimation at one or more interim analysis time points. In this presentation I will describe how the group sequential stopping boundaries may be constructed initially, how they may be modified in the presence of adaptive changes, and how the family wise type-1 error rate is controlled. For the special case of adaptive two-stage designs comparisons will be made to an alternative approach in which the independent p-values from the two stages are combined with pre-specified weights.
Please RSVP to attend.
- Medical College of Wisconsin
- 8701 Watertown Plank Rd.
- Kerrigan Auditorium M1540
- Milwaukee, WI 53226