Ophthalmology Grand Rounds
Exploring Pathologies and Treatments of Optic Neuropathy using a Zebrafish Animal Model
Ross Collery, PhD
Assistant Professor of Ophthalmology & Visual Sciences
Assistant Professor of Cell Biology, Neurobiology and Anatomy
In this session, you will learn: However, the root causes of glaucoma with damage and loss to retinal ganglion cells (RGCs) are numerous and diverse, emerging evidence indicates that subtypes of glaucoma and other neurodegenerative diseases may converge on mitochondrial dysfunction, highlighting a potential target site for treatment regardless of glaucoma subtype. We have used zebrafish to study glaucomatous phenotypes, and to develop novel tools for assessing mitochondrial damage and dysfunction. In this study, we will disrupt zebrafish opa1 whose mutations cause autosomal dominant optic atrophy (ADOA) via disruption of normal mitochondrial dynamics. Subsequently, we will assess therapeutic potential to restore normal mitochondrial dynamics in zebrafish RGCs using pharmacological approaches.