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Department of Biochemistry Research Lab Launches The O-GlcNAc Database

Department of Biochemistry research lab launches the O-GlcNAc Database

Established in the Department of Biochemistry since February 2019, Dr. Stephanie Olivier-Van Stichelen has been studying a post-translational modification of proteins called O-GlcNAcylation since her scientific beginnings.

Over the past 35 years, ~1700 articles have characterized protein O-GlcNAcylation. Found in almost all living organisms, this post-translational modification of serine and threonine residues is highly conserved and key to biological processes. With half of the primary research articles using human models, the O-GlcNAcome recently reached a milestone of 5000 human proteins identified.

However, this field was missing an inventory of those proteins, browsable for all the scientific community to use. When COVID-19 hit and they were forced out of the lab, Dr. Olivier-Van Stichelen's team took on the task of cataloguing all the O-GlcNAcylated proteins described to date and created the online O-GlcNAc database platform. There, they provide an extensive inventory of O-GlcNAcylated proteins (5000+), their O-GlcNAc sites (7000+), and corresponding references.

Want to know if your favorite protein of interest is modified? Please visit the O-GlcNAc database website.