U2-Physicians 3F Hall Hub Back-hero

MCW Vision Research Team Publishes Findings in JAMA Ophthalmology

Optical Coherence Tomography Angiography (OCTA) allows non-invasive visualization of the retinal blood vessels and is being used more and more to detect and diagnose a number of retinal and systemic diseases. MCW researchers recently published a study that demonstrates that a vast majority of studies involving OCTA are using inaccurate data due to not accounting for individual differences in eye size.

“Depending on the OCTA measurements being made, this can result in errors of as much 50%,” explained lead author Joseph Carroll, PhD, the Richard O. Schultz, MD/Ruth Works Professor in Ophthalmology and director of the Advanced Ocular Imaging Program. “We felt it was important to conduct this study to raise awareness of the issue for clinicians, researchers, and device manufacturers. I can think of no other scenario where a medical device is knowingly being used to generate inaccurate data, with hundreds of studies basing important conclusions on such data.”

The study, “Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies,” was published in JAMA Ophthalmology Online on Nov. 27.

MCW researchers involved in the study include lead authors Dr. Carroll; Rachel Linderman, graduate student in Cell Biology, Neurobiology and Anatomy; Samantha Llanas, third-year medical student in the Clinical and Translational Research Pathway.

Collaboration on this study from outside of MCW includes Fred K. Chen, MBBS, PhD from The University of Western Australia, Perth.

View the full publication