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New Grant to be Used to Develop Innovative EPR Spectrometer Technologies for Biomedical Research

Candice Klug, PhD, James S. Hyde Professor of Biophysics and director of the National Biomedical EPR Center, and Michael Lerch, PhD, assistant professor of biophysics, were awarded a four-year, $1.56 million new R01 grant titled “Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research” from the National Institute of General Medical Sciences.

Electron paramagnetic resonance (EPR) spectroscopy is a critically important technique in biomedical research with a unique ability to detect naturally occurring or engineered unpaired electrons in complex biological environments. Drs. Klug and Lerch and their team will develop two innovative EPR spectrometer technologies with outstanding sample sensitivity that are easy to use and widely available to the scientific community. The resulting state-of-the-art prototypes will provide a transformative increase in throughput that will enable a wide range of new applications in biomedical EPR spectroscopy studies including structural biology, metalloprotein research, redox biology, rational drug design, and clinical diagnostics for a range of disease areas.