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MCW researchers receive $100,000 pilot grant to investigate breast cancer treatment

Milwaukee, June 27, 2017 – The Medical College of Wisconsin (MCW) received a two-year, $100,000 pilot grant from the MCW Cancer Center and Wisconsin Breast Cancer Showhouse to investigate breast cancer treatment. The WBCS is an organization that supports early stage breast cancer and prostate cancer research at MCW.

Guan Chen, MD, PhD, professor of pharmacology and toxicology at MCW, is the principal investigator of the grant, entitled, "Disrupt a Signaling Circuit for the Treatment of Breast Cancer."

Triple negative breast cancer (TNBC) has the worst prognosis among all types of breast cancers. There is an urgent need to identify unique TNBC genes to target new treatments of this cancer, and Dr. Chen is working with a gene known to contribute to TNBC breast cancer metastasis. His goal is to identify a novel target to disrupt the gene to establish a new approach to treating TNBC.

Dr. Chen's overall research interests focus on two main areas: ras, the most established cancer gene whose mutation occurs commonly in human colon and breast cancer; and nuclear receptors, which play an important role in reproduction, homeostasis and cancer development.

"Dr. Chen is a talented cancer researcher who is committed to finding better treatments for women with triple negative breast cancer, a serious issue in Milwaukee and throughout southeastern Wisconsin," said Ming You, MD, PhD, director of the MCW Cancer Center. "We are grateful to WBCS for helping us fund this exciting research project, and this is a great example of how WBCS is a true driver of meaningful cancer research that impacts patients and the entire community."

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