Yiliang Chen Laboratory

Location

Versiti Blood Research Institute
Room 235

General Interests

Metabolism, Immunology

Research Areas

Project 1: Study of CD36 and its signaling partners such as Na/K-ATPase in signal transduction for macrophage activation

Project 2: Study of fatty acid trafficking and regulation that is coupled with mitochondria functions

Project 3: Study of mitochondrial ROS production and their influence in efferocytosis

Project 4: Study of CD36/Pim1 pathway in foam cell formation and development of atherosclerosis

Current Members

Jackie Chang

Assistant Lab Technician

Vaya Chen, BE

Lab Technician

Lance Vick

Graduate Student

Jue Zhang, PhD

Postdoctoral Fellow

Targeting mitochondrial dynamics and redox regulation in cardiovascular diseases.

(Beg MA, Huang M, Vick L, Rao KNS, Zhang J, Chen Y.) Trends Pharmacol Sci. 2024 Apr;45(4):290-303 PMID: 38458847 SCOPUS ID: 2-s2.0-85187360123 03/09/2024
Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney.

(Hou Y, Tan E, Shi H, Ren X, Wan X, Wu W, Chen Y, Niu H, Zhu G, Li J, Li Y, Wang L.) Cell Mol Life Sci. 2024 Jan 11;81(1):23 PMID: 38200266 PMCID: PMC10781825 SCOPUS ID: 2-s2.0-85181875396 01/11/2024
Na/K-ATPase signaling tonically inhibits sodium reabsorption in the renal proximal tubule.

(Mukherji ST, Brambilla L, Stuart KB, Mayes I, Kutz LC, Chen Y, Barbosa LA, Elmadbouh I, McDermott JP, Haller ST, Romero MF, Soleimani M, Liu J, Shapiro JI, Blanco GV, Xie Z, Pierre SV.) FASEB J. 2023 Apr;37(4):e22835 PMID: 36856735 PMCID: PMC10028530 SCOPUS ID: 2-s2.0-85149427345 03/02/2023
Plasma tissue-type plasminogen activator is associated with lipoprotein(a) and clinical outcomes in hospitalized patients with COVID-19

(Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z.) Research and Practice in Thrombosis and Haemostasis. August 2023;7(6) SCOPUS ID: 2-s2.0-85169507694 08/01/2023
Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL.

(Pillai SS, Pereira DG, Zhang J, Huang W, Beg MA, Knaack DA, de Souza Goncalves B, Sahoo D, Silverstein RL, Shapiro JI, Sodhi K, Chen Y.) Front Cardiovasc Med. 2023;10:1046495 PMID: 37180782 PMCID: PMC10174328 SCOPUS ID: 2-s2.0-85159873988 05/14/2023
Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.

(Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y.) iScience. 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate.

(Chen Y, Zhang J, Cui W, Silverstein RL.) J Exp Med. 2022 Jun 06;219(6) PMID: 35438721 PMCID: PMC9022290 SCOPUS ID: 2-s2.0-85128794972 04/20/2022
Editorial: The Roles of Lipids in Immunometabolism: The Crosstalk Between Lipid Metabolisms and Inflammation.

(Zhang J, Dai W, Chen Y.) Front Cardiovasc Med. 2022;9:938535 PMID: 35811702 PMCID: PMC9257247 07/12/2022
AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism.

(Palma FR, Ratti BA, Paviani V, Coelho DR, Miguel R, Danes JM, Zaichik SV, de Abreu AL, Silva SO, Chen Y, Silverstein RL, Karan U, Jones DP, Bonini MG.) Oncogene. 2021 Sep;40(36):5455-5467 PMID: 34290400 PMCID: PMC8669831 SCOPUS ID: 2-s2.0-85110982210 07/23/2021
CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys.

(Hou Y, Wang Q, Han B, Chen Y, Qiao X, Wang L.) Cell Death Dis. 2021 May 21;12(6):523 PMID: 34021126 PMCID: PMC8140121 SCOPUS ID: 2-s2.0-85106615244 05/23/2021
Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer.

(Xin G, Chen Y, Topchyan P, Kasmani MY, Burns R, Volberding PJ, Wu X, Cohn A, Chen Y, Lin CW, Ho PC, Silverstein R, Dwinell MB, Cui W.) Cancer Immunol Res. 2021 Apr;9(4):454-469 PMID: 33579728 PMCID: PMC8137571 SCOPUS ID: 2-s2.0-85104420312 02/14/2021
Regulation of Na/K-ATPase expression by cholesterol: isoform specificity and the molecular mechanism.

(Zhang J, Li X, Yu H, Larre I, Dube PR, Kennedy DJ, Tang WHW, Westfall K, Pierre SV, Xie Z, Chen Y.) Am J Physiol Cell Physiol. 2020 Dec 01;319(6):C1107-C1119 PMID: 32997514 PMCID: PMC7792677 SCOPUS ID: 2-s2.0-85098226317 10/01/2020