William S. Sly, MD
“Enzyme Therapy for MPS VII: The Long Journey from Bench to Bedside”
Dr. William S. Sly, MD did his undergraduate work at Saint Louis University and obtained his medical degree from the university’s School of Medicine in 1957. He received training at Washington University’s School of Medicine, the National Institutes of Health, the Centre National de la Recherche Scientifique in Paris and University of Wisconsin, before joining the Washington University, School of Medicine faculty in 1964. In 1984, he was appointed the Alice A. Doisy Professor and chairman of the Edward A. Doisy Department of Biochemistry and Molecular Biology at Saint Louis University. In 2007, he was also named the inaugural holder of the James B. and Joan C. Peter Endowed Chair in Biochemistry and Molecular Biology. He is a member of the National Academy of Sciences since 1989.
Dr. Sly is an internationally renowned physician and scientist who has contributed greatly to the understanding of inborn errors of metabolism. He and his research group described the first patient with mucopolysaccharidosis VII, later termed Sly syndrome in 1973. This research provided the rationale for enzyme replacement therapy in Gaucher’s disease, the most common lysosomal storage disease, and has encouraged the development of enzyme replacement for other lysosomal diseases.
In addition, Dr. Sly identified the first inherited deficiency of a human carbonic anhydrase and characterized the associated bone, brain, and kidney disease. Also, he has conducted extensive research on hereditary hemochromatosis.
Charles Fumito Taketa, PhD
Charles Fumito Taketa was born March 10, 1926, in Waimea on the island of Kauai, Hawaii. He received his A.B. at Washington University in 1950 and his PhD from the University of Wisconsin-Madison in 1957.
In 1958, he was appointed to the faculty of Marquette University School of Medicine as an instructor in Biochemistry and later promoted to Assistant Professor. As the school became the Medical College of Wisconsin in 1967, he continued his ascent to Associate Professor, then to Professor in 1973. From 1980 to 1982, he was acting Chairman, and from 1982 he was Vice Chairman of the Department of Biochemistry. His research career, which was devoted to understanding the chemical basis of hemoglobin function and later the toxicity of organotin compounds, was supported by the National Institutes of Health, the Wisconsin Heart Foundation, the American Cancer Society, and the Midwest Children's Cancer Center. He was a Fogarty Scholar at Kings College, London from 1975 to 1976, and in 1987 he received the Medical College's Distinguished Service Award. He died on June 1, 1990.
Friends and family of Charles Fumito Taketa established the Charles Fumito Taketa Memorial Fund at the Medical College of Wisconsin to promote graduate education in Biochemistry.
Past Invited Speakers
Ajit Varki, MD - University of California, San Diego
Melanie H. Cobb, PhD - UT Southwestern Medical Center
John Markley, PhD - University of Wisconsin – Madison
Natalie Ahn, PhD - University of Colorado, Boulder
Jack Dixon, PhD - University of California, San Diego
Phillip A. Cole, MD, PhD - Johns Hopkins University, Maryland
William S. Reznikoff, PhD - University of Wisconsin – Madison
Rowena G. Matthews, PhD - University of Michigan
Gregory Petsko, PhD - Brandeis University
Hector DeLuca, PhD - University of Wisconsin – Madison
James L. Lessard, PhD - Children’s Hospital Medical Center, Cincinnati
Jonathan Stamler, MD - Howard Hughes Medical Institute, Duke University Medical Center
Bettie Sue Masters, PhD - University of Texas Health Science Center
Richard T. Okita, PhD - Washington State University
Robert G. Kemp, PhD - University Health Science Center, Chicago Medical School
Grant Mauk, PhD - University of British Columbia
John W. Suttie, PhD - University of Wisconsin – Madison