Cardiovascular Center

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Dr. Ivor Benjamin,
MD, FAHA, FACC
Director

Dr. Benjamin is a physician-scientist and general cardiology consultant who has research interests in the genetic basis of heart disease, myocardial infarction, and regenerative medicine. He has been actively engaged, along with his trainees and co-investigators, in basic and translational collaborative research for over two decades. Dr. Benjamin has a track record of innovative research exemplified by the NIH Director’s Pioneer Award, which has supported his commitment to transformative lines of investigation on signaling pathways linked to oxido-reductive stress and protein misfolding disorders in humans. Modeling of a complex multifactorial disorder such as atrial fibrillation presents both ‘high risk/high reward’ translational sciences for which there is no existing support for this work. Our multidisciplinary translational program is to exploit standard approaches (e.g., induced pluripotent stem cells, high throughput electrophysiological screening) to improve clinical decision making for therapeutic intervention and, ultimately, disease prevention.

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EKG reading

Vision and Mission

Vision: The Cardiovascular Community at Froedtert Hospital & the Medical College of Wisconsin aims to become the premier integrated Basic and Translational Academic Organization in the U.S.

Mission: The objective is to improve cardiovascular health in Southeast Wisconsin and beyond through innovative, cutting-edge research, and cost-efficient health care delivery.

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Center Faculty News

Recent Publication from the Benjamin Lab

Advances in induced pluripotent stem cell (iPSC) technology have set the stage for routine derivation of patient- and disease-specific human iPSC-cardiomyocyte (CM) models for preclinical drug screening and personalized medicine approaches. Peripheral blood mononuclear cells (PBMCs) are an advantageous source of somatic cells because they are easily obtained and readily amenable to transduction. Here, we report that the electrophysiological properties and pharmacological responses of PBMC-derived iPSC-CM are generally similar to those of iPSC-CM derived from other somatic cells, using patch-clamp, calcium transient, and multielectrode array (MEA) analyses.

Recently Accepted Publication

Cardiovascular Medicine Fellow, Dr. Sharath Subramanian, has been recently published in the Journal of the American College of Cardiology. This article explores whether high-dose statin treatment results in a reduction in periodontal inflammation.

Performing research

Cardiovascular Center Research

The mission of the Cardiovascular Center is to further develop strong and nationally recognized interdisciplinary cardiovascular research programs at the Medical College of Wisconsin and to promote comparable excellence in clinical care and education while developing community outreach.

Areas of Research:
 

 

Upcoming Center Events

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CVC Golf Challenge, July 14

The CVC Golf Challenge, now in its 16th year, will be held at the beautiful Chenequa Country Club on Monday, July 14. All proceeds from the event benefit cardiovascular research at the Medical College of Wisconsin.

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Page Updated 07/01/2014