Kevin Regner Lab
The primary goal of the Regner laboratory is to investigate the cellular, molecular, and genetic mechanisms involved in ischemic acute kidney injury (AKI) and kidney repair.
Kevin R. Regner, MD, MS, FASN
Chief and Professor, Department of Medicine
kregner@mcw.edu
Current projects include:
Activator of G Protein Signaling 3 in Ischemic Renal Injury. The objective of this study is to characterize the role of Activator of G protein signaling 3 (AGS3), a novel non-receptor regulator of G-protein function, in renal tubular regeneration following ischemic AKI.
Genetic mapping and gene identification for acute kidney injury in outbred rats. The objective of this study is to identify novel genes that modulate susceptibility or resistance to AKI using a novel genetic resource, heterogeneous stock rats.
Bohan Xing, BS
Research Technologist I |
bxing@mcw.edu
Recent Publications
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(Koratala A, Paudel HR, Regner KR.) American Journal of Medicine Open. 2023 Dec;10: 2667-0364 10/01/2023
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(Patidar KR, Belcher JM, Regner KR, St Hillien SA, Simonetto DA, Asrani SK, Neyra JA, Sharma P, Velez JCQ, Wadei H, Nadim MK, Chung RT, Seethapathy R, Parada XV, Ouyang T, Ufere NN, Robinson JE, McLean Diaz P, Wilechansky RM, Przybyszewski EM, Smith TN, Ali AA, Orman ES, Schulz P, Siddiqui SM, Shabbir R, Liu LJ, Cama-Olivares A, Flannery AH, Baker ML, Gunasekaran D, Aswine A, Issa R, Li J, Verma S, Chalmers D, Varghese V, Lam W, Mohamed M, Kovacic R, Gaddy A, Attieh RM, Cortes P, Semnani S, Wang L, Khemichian S, Allegretti AS, from the HRS-HARMONY consortium.) J Hepatol. 2023 Dec;79(6):1408-1417 PMID: 37517455 PMCID: PMC10807505 SCOPUS ID: 2-s2.0-85171850314 07/31/2023
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(Swanson M, Yun J, Collier DM, Seif C, Yang CY, Regner KR, Park F.) Am J Physiol Renal Physiol. 2023 Aug 01;325(2):F248-F261 PMID: 37348027 SCOPUS ID: 2-s2.0-85165546515 06/22/2023
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Update on Assessment of Estimated Glomerular Filtration Rate in Patients With Cirrhosis.
(Griffin C, Asrani SK, Regner KR.) Adv Kidney Dis Health. 2023 Jul;30(4):307-314 PMID: 37389536 06/30/2023
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Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1.
(Velez JCQ, Karakala N, Tayebi K, Wickman TJ, Mohamed MMB, Kovacic RA, Therapondos G, Kanduri SR, Allegretti AS, Belcher JM, Regner KR, Wentowski C.) Kidney360. 2023 Apr 01;4(4):e448-e456 PMID: 36763632 PMCID: PMC10278824 SCOPUS ID: 2-s2.0-85161650241 02/11/2023
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(Swanson ML, Regner KR, Moore BM 2nd, Park F.) Cannabis Cannabinoid Res. 2022 Dec;7(6):790-803 PMID: 35196117 SCOPUS ID: 2-s2.0-85147378966 02/24/2022
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(Miller B, Regner K, Sorokin A.) Biochemical and Biophysical Research Communications. 7 May 2022;603:69-74 SCOPUS ID: 2-s2.0-85125835040 05/07/2022
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(Miller B, Regner K, Sorokin A.) Biochem Biophys Res Commun. 2022 May 07;603:69-74 PMID: 35278882 PMCID: PMC8969123 SCOPUS ID: 2-s2.0-85125835040 03/13/2022
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(Williams AM, Jensen DM, Pan X, Liu P, Liu J, Huls S, Regner KR, Iczkowski KA, Wang F, Li J, Gallan AJ, Wang T, Baker MA, Liu Y, Lalehzari N, Liang M.) Kidney Int. 2022 Apr;101(4):766-778 PMID: 35114200 PMCID: PMC8940673 SCOPUS ID: 2-s2.0-85125312317 02/04/2022
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Hyperammonemia from a urea cycle disorder presenting in adulthood
(Priester TC, Khoo T, Fernández-Pérez ER, Regner KR, Tracy JA, Mitchell S, Summar ML, Babovic-Vuksanovic D.) The Open Crit Care Med J. 2009 . 02/23/2022
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Management of AKI in patients with cirrhosis
(Regner KR, Kanduri SR, Velez JCQ.) . Curr Treat Options Gastro 2022; 20:295-315. 02/23/2022
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DNA damage is overcome by TRIP13 overexpression during cisplatin nephrotoxicity.
(Hama T, Nagesh PK, Chowdhury P, Moore BM 2nd, Yallapu MM, Regner KR, Park F.) JCI Insight. 2021 Nov 22;6(22) PMID: 34806647 PMCID: PMC8663775 SCOPUS ID: 2-s2.0-85120382452 11/23/2021