David X. Zhang Lab

David Zhang

David X. Zhang, PhD
Associate Professor, Department of Medicine
xfzhang@mcw.edu

The overall emphasis of Dr. Zhang’s research is to understand signaling mechanisms in regulation of blood vessel reactivity and homeostasis under normal states as well as in diseases such as coronary artery disease (CAD), hypertension, and diabetes. The current research is focused on the vascular regulation by ion channels such as transient receptor potential (TRP) channels and K+ channels.

Yoshinori Nishijima

Yoshinori Nishijima
Research Associate
ynishijima@mcw.edu

My current research is focused on understanding the transient receptor potential vanilloid 4 channels to angiotensin II-induced impairment of vasodilation in animals and humans. I am also interested in the role of vascular smooth muscle potassium channels in hydrogen peroxide-induced vasodilation in human arterioles, in health and disease.

Shengcao Zhanglab

Sheng Cao
Postdoctoral Fellow
scao@mcw.edu

My current research is focused on determining whether arachidonic acid (AA) serves as a key upstream mediator of flow-mediated dilation (FMD) in human coronary arteriole (HCA) and define the molecular mechanisms by which AA activates the transient receptor potential vallinoid type 4 (TRPV4) channel in coronary endothelial cells.

Ankush Korishettar

Ankush Korishettar
Research Assistant
akorishettar@mcw.edu

My current research is focused on characterizing the function of smooth muscle TRPV1 ion channels in controlling the diameter of small blood vessels and whether they contribute to the vasoconstriction response elicited by physiological vasoconstrictors such as endothelin-1.

Structure of human TRPV4 in complex with GTPase RhoA.

(Nadezhdin KD, Talyzina IA, Parthasarathy A, Neuberger A, Zhang DX, Sobolevsky AI.) Nat Commun. 2023 Jun 23;14(1):3733 PMID: 37353478 PMCID: PMC10290124 SCOPUS ID: 2-s2.0-85162777271 06/24/2023
Inhibiting NADPH Oxidases to Target Vascular and Other Pathologies: An Update on Recent Experimental and Clinical Studies.

(Sylvester AL, Zhang DX, Ran S, Zinkevich NS.) Biomolecules. 2022 Jun 13;12(6) PMID: 35740948 PMCID: PMC9221095 SCOPUS ID: 2-s2.0-85131782032 06/25/2022
NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels.

(Xie Y, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zimmermann MT, Wilcox DA, Gutterman DD, Shen Y, Zhang DX.) Basic Res Cardiol. 2022 Apr 25;117(1):24 PMID: 35469044 PMCID: PMC9119129 SCOPUS ID: 2-s2.0-85128849246 04/27/2022
Prolonged endothelial-dysfunction in human arterioles following infection with SARS-CoV-2.

(Nishijima Y, Hader SN, Hanson AJ, Zhang DX, Sparapani R, Gutterman DD, Beyer AM.) Cardiovasc Res. 2022 Jan 07;118(1):18-19 PMID: 34755839 PMCID: PMC8689948 SCOPUS ID: 2-s2.0-85123651313 11/11/2021
Endothelial Rap1 (Ras-Association Proximate 1) Restricts Inflammatory Signaling to Protect From the Progression of Atherosclerosis.

(Singh B, Kosuru R, Lakshmikanthan S, Sorci-Thomas MG, Zhang DX, Sparapani R, Vasquez-Vivar J, Chrzanowska M.) Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):638-650 PMID: 33267664 PMCID: PMC8105264 SCOPUS ID: 2-s2.0-85104181830 12/04/2020
Endothelin-1 potentiates TRPV1-mediated vasoconstriction of human adipose arterioles in a protein kinase C-dependent manner.

(Korishettar AM, Nishijima Y, Wang Z, Xie Y, Fang J, Wilcox DA, Zhang DX.) Br J Pharmacol. 2021 Feb;178(3):709-725 PMID: 33184836 PMCID: PMC9121782 SCOPUS ID: 2-s2.0-85098221966 11/14/2020
Corrigendum: Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium.

(Kosuru R, Singh B, Lakshmikanthan S, Nishijima Y, Vasquez-Vivar J, Zhang DX, Chrzanowska M.) Front Cell Dev Biol. 2021;9:741935 PMID: 34422844 PMCID: PMC8378398 08/24/2021
Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium.

(Kosuru R, Singh B, Lakshmikanthan S, Nishijima Y, Vasquez-Vivar J, Zhang DX, Chrzanowska M.) Front Cell Dev Biol. 2021;9:687598 PMID: 34222255 PMCID: PMC8247587 07/06/2021
Myocardin and Kv1 Channels: A Paradigm Shift in Treating Vascular Smooth Muscle Cell-Related Proliferative Disease?

(Zhang DX, Gutterman DD.) Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):2454-2456 PMID: 31770031 PMCID: PMC6980742 SCOPUS ID: 2-s2.0-85075688768 11/27/2019
TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition.

(Sharma S, Goswami R, Zhang DX, Rahaman SO.) J Cell Mol Med. 2019 Feb;23(2):761-774 PMID: 30450767 PMCID: PMC6349341 SCOPUS ID: 2-s2.0-85056765656 11/20/2018
Endothelin receptor A and p66Shc regulate spontaneous Ca2+ oscillations in smooth muscle cells controlling renal arterial spontaneous motion.

(Palygin O, Miller BS, Nishijima Y, Zhang DX, Staruschenko A, Sorokin A.) FASEB J. 2019 Feb;33(2):2636-2645 PMID: 30303741 PMCID: PMC6338658 SCOPUS ID: 2-s2.0-85061064863 10/12/2018
Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation.

(Cao S, Anishkin A, Zinkevich NS, Nishijima Y, Korishettar A, Wang Z, Fang J, Wilcox DA, Zhang DX.) J Biol Chem. 2018 Apr 06;293(14):5307-5322 PMID: 29462784 PMCID: PMC5892583 SCOPUS ID: 2-s2.0-85045077479 02/21/2018

David X. Zhang Lab

Recent Publications