National Biomedical Electron Paramagnetic Resonance Center

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  James S. Hyde, PhD

  The James S. Hyde Professor of Biophysics
  Director of the 
National Biomedical EPR Center

  Department of Biophysics
  Medical College of Wisconsin
  8701 Watertown Plank Road
  Milwaukee, WI 53226-0509
  Phone: 414-955-4005
  Fax: 414-955-6512

  jshyde@mcw.edu  

 

 


I received my PhD from MIT in 1959 in physics, writing a dissertation on EPR, spent 16 years at Varian Associates heading their EPR research and development program, and came to the Medical College of Wisconsin in 1975 as Professor of Biophysics to help establish the National Biomedical EPR Center, a P41 Research Resource supported by the National Center for Research Resources of NIH. The grant has recently been transferred to the National Institute of Biomedical Imaging and Bioengineering (NIBIB) and has been continuously funded since 1976. I continue to serve as director of the EPR Center.

My personal interest in EPR, with support from two R01 awards as well as the P41 grant, is to contribute to the development of EPR instrumentation and to extend the ways in which existing EPR instrumentation can be used for new categories of biomedical problems. Our papers on multiquantum EPR and pulse saturation recovery EPR are not only examples of interesting spin physics but also hold great promise for research using site-directed spin labeling (SDSL), such as the programs of research by my colleagues at MCW, Drs. Jimmy Feix and Candice Klug. Our papers on time-locked sub-sampling (TLSS) detection bring modern digital signal acquisition methods to EPR spectroscopy. It is believed that the techniques described in these papers will serve as the foundation for the next generation of EPR spectrometers. We have developed a digital detection spectrometer for use at Q-band. This instrument can be used for multiquantum EPR and ELDOR, standard EPR, and saturation recovery and pulse ELDOR EPR. We have recently extended these capabilities to W-band using frequency-translation technology.

In the last few years, we have published a series of papers on EPR sample-containing resonators using finite element modeling of electromagnetic fields. We studied the effect of an aqueous sample on field distribution, defined a new principle for design of aqueous-sample cuvettes, and invented a new class of resonators – the so-called Uniform-Field cavities. These advances would hardly have been possible without improved software and increased computing power.

In 1984, I became interested in MRI, which led to a program of research and development of surface coils and gradient coils. My students and I wrote the first paper on functional magnetic resonance imaging (fMRI) of the sensorimotor system in human brain in 1992, as well as the first paper on functional connectivity MRI, now called fcMRI, in 1995.  Since the acquisition of the 9.4T small-animal scanner, my interests have increasingly shifted to fMRI and fcMRI in rat brain at high spatial resolution.  I have an active collaboration with reconstructive surgeons in the Department of Plastic Surgery.  Manipulation of the nerves of the rat forelimb, including use of embedded electrodes, nerve transection, and nerve transfer, is leading both to new insights in neuroscience and to new opportunities in translational research.  A just-funded new project in collaboration with the Department of Radiology involves real-time analysis of fMRI and fcMRI data from patients.  We propose to develop new ways to deal with the problem of motion, which can be severe in individuals who are ill or elderly.

EPR and MRI research is carried out in cooperation with staff engineers and scientists, several long-standing collaborators including Prof. Wojciech Froncisz from the Jagiellonian University in Krakow, Poland, and predoctoral students as well as postdoctoral fellows.


Selected EPR Publications

Selected MRI Publications

 

Education

  • MIT (Cambridge, MA), PhD, 1959, Physics
  • MIT (Cambridge, MA), BS, 1954, Physics

Employment History

  • 1980-present - Director, National Biomedical EPR Center, Medical College of Wisconsin
  • 1992-1998 - Director, Biophysics Research Institute, Medical College of Wisconsin
  • 1985-1992 - Chief, Biophysics Section, Department of Radiology, Medical College of Wisconsin
  • 1981-present - Adjunct Professor, Biomedical Engineering, Marquette University
  • 1975-present - Professor of Biophysics, Medical College of Wisconsin
  • 1959-1975 - Senior Scientist and Manager, EPR Research & Design, Varian Associates, Palo Alto, California

Honors and Awards

  • 2009, MIT Club of Wisconsin's Annual Technology Achievement Award
  • 2008, Fellow, ISMAR (International Society of Magnetic Resonance)
  • 2008, Distinguished Service Award, Medical College of Wisconsin
  • 2002, Fellow, International EPR Society
  • 1999, Gold Medal, The International Society for Magnetic Resonance in Medicine
  • 1995, Zavoisky Award, Kazan
  • 1993, Gold Medal, International EPR/ESR Society
  • 1989, Bruker Prize of the Royal Society of Chemistry, United Kingdom
  • 1989, Doctoris Honoris Causa, Jagiellonian University, Krakow, Poland
  • 1975, Fellow of The American Physical Society
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