Roy Silverstein, MD
Professor and Chair Emeritus, Department of Medicine; Associate Director, Medical Scientist Training Program; Senior Investigator, Versiti Blood Research Institute; Professor of Cell Biology and Physiology
Locations
- Medical College of Wisconsin
Department of Medicine
Division of Hematology and Oncology
Biography
Roy Silverstein, MD, is Professor and Chair Emeritus of Medicine at the Medical College of Wisconsin Division of Hematology and Oncology. He graduated from Emory University School of Medicine in 1979, and then completed his residency and fellowship in hematology and medical oncology at New York Hospital-Cornell Medical Center. Dr. Silverstein is board certified in Internal Medicine, Hematology, and Oncology.
Research Interests
Dr. Silverstein's current research interests include laboratory based translational research on the molecular, cellular, and genetic causes of common human vascular disorders, including thrombosis, angiogenesis, and atherosclerosis. His clinical interests include thrombosis, hemostasis, and myeloproliferative neoplasms. Dr. Silverstein has published over 200 articles which include papers in Blood, Nature Medicine, J. Clinical Invest, and J. Exp Med.
Publications
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Na/K-ATPase Signaling in Adipocytes Promotes Atherosclerosis.
(De Souza Goncalves B, Wang Y, Pillai SS, Luu QQ, Triniac H, Lakhani HV, Chaudhry MA, Zheng Z, Shapiro JI, Silverstein RL, Sodhi K, Chen Y.) Arterioscler Thromb Vasc Biol. 2026 Oct;46(10):e325070 PMID: 42657466 PMCID: PMC13523103 SCOPUS ID: 2-s2.0-105048641173 08/27/2026
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Macrophage PIM1 Drives Atherosclerosis by Enhancing Foam Cell Formation Via CD36.
(Beg MA, Luu QQ, Chen V, Wang Y, Xin G, Cui W, Silverstein RL, Chen Y.) Arterioscler Thromb Vasc Biol. 2026 Sep;46(9):e324938 PMID: 42558044 PMCID: PMC13464522 SCOPUS ID: 2-s2.0-105048558983 08/06/2026
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FcR γ-chain and platelet hyperactivity.
(Silverstein RL.) Blood Adv. 2025 Nov 25;9(22):5790-5791 PMID: 41236722 PMCID: PMC12663002 11/14/2025
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Chronic diseases alter the platelet rheostat to promote hyperreactivity and thrombosis.
(Silverstein RL.) J Clin Invest. 2025 Aug 15;135(16) PMID: 40829178 PMCID: PMC12352885 SCOPUS ID: 2-s2.0-105013688601 08/19/2025
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Just Say NO to CD36 Expression: A Regulatory Pathway With Implications in Many Chronic Diseases.
(Silverstein RL.) Arterioscler Thromb Vasc Biol. 2025 Jul;45(7):1087-1089 PMID: 40469036 PMCID: PMC12197822 SCOPUS ID: 2-s2.0-105007515580 06/05/2025
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Distinguishing ASH clinical practice guidelines from other forms of ASH clinical advice.
(Cuker A, Kunkle R, Bercovitz RS, Byrne M, Djulbegovic B, Haberichter SL, Holter-Chakrabarty J, Lottenberg R, Pai M, Rezende SM, Seftel MD, Silverstein RL, Terrell DR, Cheung MC.) Blood Adv. 2024 Jun 11;8(11):2960-2963 PMID: 38593461 PMCID: PMC11302374 SCOPUS ID: 2-s2.0-85196395496 04/09/2024
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Targeting Cysteine Oxidation in Thrombotic Disorders.
(Yang M, Silverstein RL.) Antioxidants (Basel). 2024 Jan 09;13(1) PMID: 38247507 PMCID: PMC10812781 01/22/2024
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(Chen V, Zhang J, Chang J, Beg MA, Vick L, Wang D, Gupta A, Wang Y, Zhang Z, Dai W, Kim M, Song S, Pereira D, Zheng Z, Sodhi K, Shapiro JI, Silverstein RL, Malarkannan S, Chen Y.) Front Cardiovasc Med. 2024;11:1436865 PMID: 39156133 PMCID: PMC11327822 SCOPUS ID: 2-s2.0-85201434395 08/19/2024
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Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes.
(Dai W, Zhang H, Lund H, Zhang Z, Castleberry M, Rodriguez M, Kuriakose G, Gupta S, Lewandowska M, Powers HR, Valmiki S, Zhu J, Shapiro AD, Hussain MM, López JA, Sorci-Thomas MG, Silverstein RL, Ginsberg HN, Sahoo D, Tabas I, Zheng Z.) Science. 2023 Sep;381(6661):eadh5207 PMID: 37651538 PMCID: PMC10697821 SCOPUS ID: 2-s2.0-85169348601 08/31/2023
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(Byrne M, Mattison R, Bercovitz R, Lottenberg R, Rezende SM, Silverstein R, Terrell D, Kunkle R, Smith D, Bollard C, Haberichter S, Holter-Chakrabarty J, Pai M, Cheung M, Cuker A, Seftel M, Djulbegovic B.) Blood Adv. 2023 Aug 22;7(16):4323-4326 PMID: 37186271 PMCID: PMC10424133 05/15/2023