Rashmi Sood, PhD

Associate Professor

Locations

Pathology & Laboratory Medicine
TBRC

Contact Information

Education

PhD, Tata Institute of Fundamental Research, Mumbai, India
Postdoctoral Fellow, Blood Research Institute, Versiti Blood Center of Wisconsin, Milwaukee, WI

Learn more about the Sood Laboratory

Biography

Dr. Rashmi Sood received her PhD in Molecular Biology from the Tata Institute of Fundamental Research, Mumbai, India. Her postdoctoral studies were conducted at the Blood Research Institute at Versiti Blood Center of Wisconsin, Milwaukee, where she specialized in coagulation and vascular biology. Dr. Sood’s studies are largely focused on understanding the role of thrombotic and hemorrhagic complications in placenta-mediated adverse pregnancy outcomes. Her laboratory develops and utilizes rodent models to identify maternal and fetal factors that regulate placental and uterine hemostasis. In parallel, her laboratory seeks to discover predictive biomarkers that can be used to identify high-risk pregnancies in women.

Honors and Awards

Basil O’ Connor Starter Scholar Award, March of Dimes Foundation
Scientist Development Grant, American Heart Association
Fellow of the American Heart Association
R01 “Role of maternal platelets in placental and pregnancy complications”, National Institutes of Health
AHW award “Immune crosstalk in preterm birth”, Advancing a Healthier Wisconsin Foundation

Research Interests

Extraembryonic tissue development
Coagulation and platelet disorders
Uterine and placental hemostasis
Placenta-mediated pregnancy complications
Perinatal health/Prematurity
Biomarkers of pregnancy complications

The endothelial protein C receptor plays an essential role in the maintenance of pregnancy.

(Castillo MM, Yang Q, Sigala AS, McKinney DT, Zhan M, Chen KL, Jarzembowski JA, Sood R.) Sci Adv. 2020 Nov;6(45) PMID: 33158859 PMCID: PMC7673707 SCOPUS ID: 2-s2.0-85095802928 11/08/2020
Maintaining extraembryonic expression allows generation of mice with severe tissue factor pathway inhibitor deficiency.

(Castillo MM, Yang Q, Zhan M, Pan AY, Lawlor MW, Mast AE, Sood R.) Blood Adv. 2019 Feb 12;3(3):489-498 PMID: 30755437 PMCID: PMC6373739 SCOPUS ID: 2-s2.0-85061474836 02/14/2019
Humanized GPIbα-von Willebrand factor interaction in the mouse.

(Kanaji S, Orje JN, Kanaji T, Kamikubo Y, Morodomi Y, Chen Y, Zarpellon A, Eberhardt J, Forli S, Fahs SA, Sood R, Haberichter SL, Montgomery RR, Ruggeri ZM.) Blood Adv. 2018 Oct 09;2(19):2522-2532 PMID: 30287479 PMCID: PMC6177644 SCOPUS ID: 2-s2.0-85069786057 10/06/2018
Variable phenotypic penetrance of thrombosis in adult mice after tissue-selective and temporally controlled Thbd gene inactivation.

(van Mens TE, Liang HH, Basu S, Hernandez I, Zogg M, May J, Zhan M, Yang Q, Foeckler J, Kalloway S, Sood R, Karlson CS, Weiler H.) Blood Adv. 2017 Jun 27;1(15):1148-1158 PMID: 28920104 PMCID: PMC5600150 09/19/2017
The Endothelial Protein C Receptor plays an essential role in the maintenance of Pregnancy

(Castillo MM, Yang Q, Sigala AS, McKinney DT, Zhan M, Chen KL, Jarzembowski JA, Sood R.) BioRxiv. https://doi.org/10.1101/2020.02.05.935940 02/05/2020
Deficiency of Protease Activated Receptor 3 in the Mother Prevents Placenta-Mediated Death of Endothelial Protein C Receptor Null Mice, but Uncovers an Obligate Requirement of EPCR in the Embryo and Neonate.

(Castillo MM, Yang Q, Sood R.) Blood. 134 (Supplement_1): 2382; https://doi.org/10.1182/blood-2019-131453 11/13/2019
Genetic Absence of Integrin alpha2b Improves Survival of Tissue Factor Pathway Inhibitor Null Mice but Results in Hydrocephalus Formation

(Castillo M, Ott E, Wujek R, Qiuli L, Schmainda K, Cohen S, Sood R.) Blood. 134 (Supplement_1): 3626; https://doi.org/10.1182/blood-2019-131811 11/13/2019
Animal Models Demonstrate a Critical Role of Factor VIII in Par4-and Platelet-Mediated Pathology

(Castillo M, Yang Q, McKinney D, Shi Q, Sood R.) Blood. 134 (Supplement_1): 1057; https://doi.org/10.1182/blood-2019-123290 11/13/2019
Absence of platelet thrombin receptor PAR4 prevents thrombotic and stroke-like phenotypes of thrombomodulin deficient mice

(Storage M, Yang Q, Zhan M, Sood R.) Res Pract Thromb Haemost. 1 (S1): 87; OC 02.5; https://doi.org/10.1002/rth2.12012 06/23/2017
Maintaining extraembryonic expression allows generation of adult mice with Tissue Factor Pathway Inhibitor gene disruption

(Storage M, Yang Q, Zhan M, Sood R.) Res Pract Thromb Haemost. 1 (S1): 86; OC 02.1; https://doi.org/10.1002/rth2.12012 06/23/2017
Vasculogenesis and Angiogenesis

(Chun CZ, Sood R, Ramchandran R.) In: North P., Sander T. (eds) Vascular Tumors and Developmental Malformations.. Molecular and Translational Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3240-5_3 01/01/2016
Genetic Absence of Thrombin Receptor Par4 Overcomes the Obligate Requirement of EPCR in Mouse Placenta

(Storage MM, An J, Liang H, Yang Q, Zogg M, Zhan M, Weiler H, Sood R.) Blood. 126 (23): 425; https://doi.org/10.1182/blood.V126.23.425.425 12/03/2015